Dapavel S 10/100 mg Tablet (10 Tab)

Dapavel S 10/100 Tablet Overview:

Dapavel S 10/100 Tablet is a prescription medication specifically designed for managing type 2 diabetes mellitus in adults. It combines two active ingredients to help control blood sugar levels when diet and exercise alone are not enough. It is particularly useful for patients who need a combination therapy to achieve better glycemic control. The tablet is film-coated for easy swallowing and is intended for long-term use under medical supervision. By targeting different mechanisms in the body, Dapavel S 10/100 Tablet helps reduce high blood glucose, potentially lowering the risk of diabetes-related complications like heart disease and kidney issues. It is not suitable for type 1 diabetes or diabetic ketoacidosis, and regular monitoring of blood sugar is essential while using it.

Composition:

Each film coated tablet contains- Dapagliflozin Propanediol Monohydrate equivalent to Dapagliflozin: 10 mg and Sitagliptin Phosphate Monohydrate equivalent to Sitagliptin: 100 mg.

Colours: Titanium Dioxide & Ferric Oxide Red.

Uses & Benefits of Dapavel S 10/100 Tablet:

Dapavel S 10/100 Tablet effectively manages type 2 diabetes in adults by significantly lowering blood sugar levels, reducing HbA1c by up to 1.5%, and improving fasting and post-meal glucose control. It enhances glycemic management when diet and exercise alone are insufficient, helping prevent diabetes-related complications.

How Dapavel S 10/100 Tablet Works:

Dapavel S 10/100 Tablet works through the complementary actions of its two components. Dapagliflozin, an SGLT2 inhibitor, blocks the reabsorption of glucose in the kidneys, allowing excess sugar to be excreted in the urine, which lowers blood glucose independently of insulin. Sitagliptin, a DPP-4 inhibitor, increases incretin hormone levels, which stimulates insulin release from the pancreas in response to meals and suppresses glucagon production, reducing glucose output from the liver. Together, they provide a dual approach to blood sugar regulation.

Dosage of Dapavel S 10/100 Tablet:

• Usage Directions

Dapavel S 10/100 Tablet should be taken orally, preferably at the same time each day to maintain consistent blood levels. It can be consumed with or without food, but taking it with a meal may help if stomach upset occurs. Swallow the tablet whole with water; do not crush, chew, or split it. Your doctor may prescribe the right dose, based on your blood sugar response and kidney function. Regular blood tests are recommended to monitor efficacy. Always follow your healthcare provider's instructions, and combine the medication with a healthy diet, physical activity, and lifestyle changes for optimal results.

• Missed Dose

If you miss a dose of Dapavel S 10/100 Tablet, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to compensate, as this could increase the risk of side effects like low blood sugar. Setting reminders or incorporating the tablet into a daily routine can help avoid misses. If you frequently forget doses, consult your doctor for advice on better adherence strategies.

• Overdose

In case of an overdose of Dapavel S 10/100 Tablet, seek immediate medical attention or contact a poison control center. Symptoms may include severe hypoglycemia, nausea, vomiting, abdominal pain, or signs of ketoacidosis such as rapid breathing and confusion. Supportive treatment, including glucose administration if blood sugar drops too low, is typically provided. Overdose risks are higher if combined with other antidiabetic drugs, so inform emergency personnel about all medications you're taking. Prevention involves sticking to the prescribed dose and storing the medication securely away from children.

Contraindications of Dapavel S 10/100 Tablet:

Dapavel S 10/100 Tablet is contraindicated in patients with known hypersensitivity to dapagliflozin, sitagliptin, or any tablet components, which could cause severe allergic reactions. It should not be used in type 1 diabetes, diabetic ketoacidosis, or severe renal impairment due to increased risks. Patients with a history of acute pancreatitis, severe dehydration, or conditions that alter renal function, such as recent surgery or infection, should avoid it. It is also not recommended for those with moderate to severe hepatic impairment or in pediatric populations, as safety data is limited.

Precautions & Warnings of Dapavel S 10/100 Tablet:

Before starting Dapavel S 10/100 Tablet, inform your doctor about any existing conditions like kidney or heart problems, as regular monitoring of renal function and blood pressure is crucial. Be cautious if you have a history of urinary tract or genital infections, as the medication may increase these risks—maintain good hygiene and stay hydrated. Elderly patients or those on diuretics may experience dehydration or hypotension, so volume status should be assessed. Watch for signs of ketoacidosis, even if blood sugar is normal, especially during illness or stress. Discontinue the tablet if pancreatitis is suspected, and avoid abrupt stops without medical advice. Periodic checks for vitamin B12 levels may be needed with long-term use.

Side Effects of Dapavel S 10/100 Tablet:

Common side effects of Dapavel S 10/100 Tablet include urinary tract infections, genital mycotic infections, nasopharyngitis, and upper respiratory tract issues, affecting up to 20-30% of users in studies. Other frequent reactions are dehydration, headache, back pain, joint pain, diarrhea, nausea, and increased urination due to the glucose excretion mechanism. Hypoglycemia may occur, especially when combined with insulin or sulfonylureas, with symptoms like shakiness or confusion. Serious but less common side effects include ketoacidosis, severe infections, or hypersensitivity reactions like rash or swelling. Most side effects are mild and resolve with time, but report persistent or severe ones to your doctor promptly.

Safety Related Concerns of Dapavel S 10/100 Tablet:

• Pregnancy

Dapavel S 10/100 Tablet is not recommended during pregnancy due to limited human data and potential risks to the developing fetus. Animal studies suggest possible adverse effects on kidney development from dapagliflozin, while sitagliptin has shown no major issues but lacks sufficient evidence. If pregnancy occurs while on the medication, discontinue it immediately and consult your healthcare provider for safer alternatives like insulin. If you are planning pregnancy, then discuss switching therapies in advance to ensure optimal blood sugar control without fetal harm.

• Breastfeeding

Breastfeeding mothers should avoid Dapavel S 10/100 Tablet, as dapagliflozin and sitagliptin may pass into breast milk, potentially affecting the infant's kidney function or growth. Limited studies indicate excretion in animal milk, but human data is insufficient. If the medication is essential, consider stopping breastfeeding or using alternative diabetes treatments. Always weigh benefits against risks with your doctor, and monitor the baby for any unusual symptoms if exposure occurs.

• Alcohol

Consuming alcohol while taking Dapavel S 10/100 Tablet can heighten the risk of hypoglycemia and ketoacidosis, as alcohol affects blood sugar regulation and may cause dehydration. Moderate intake might be tolerable for some, but excessive drinking could worsen side effects like nausea or dizziness. Discuss your alcohol habits with your doctor for personalized advice.

• Using Machinery & Driving

Dapavel S 10/100 Tablet may cause dizziness, fatigue, or low blood sugar, which could impair your ability to drive or operate machinery safely. These effects are more pronounced at the start of treatment or with dose changes. Avoid such activities until you know how the medication affects you, and always check blood sugar before driving. If hypoglycemia symptoms appear, stop immediately and treat with fast-acting carbs.

Food Interactions

Dapavel S 10/100 Tablet has minimal food interactions, but a balanced diet low in simple sugars enhances its effectiveness. High-carb meals may require closer monitoring, as the tablet promotes glucose excretion. No specific foods need avoidance, but staying hydrated helps prevent dehydration from increased urination. Grapefruit or excessive caffeine might slightly affect metabolism, but this is rare—consult your doctor if concerned.

Drug Interactions

Dapavel S 10/100 Tablet can interact with other medications, increasing hypoglycemia risk when used with insulin, sulfonylureas, or beta-blockers—dose adjustments may be needed. Diuretics, ACE inhibitors, or NSAIDs could heighten dehydration or kidney strain. Strong CYP3A4 inhibitors like ketoconazole may alter sitagliptin levels, while inducers like rifampin could reduce efficacy. Inform your doctor about all drugs, including over-the-counter ones, to avoid complications.

Storage Instructions:

Store below 30°C. Keep out of reach of children. Check the expiry date before use, and dispose of unused tablets properly through a pharmacy take-back program.

Other Notes:

Always use Dapavel S 10/100 Tablet as part of a comprehensive diabetes plan, including regular exercise and blood monitoring. It does not cure diabetes but helps manage it effectively. Periodic doctor visits are vital for assessing progress and adjusting treatment. If switching from separate dapagliflozin or sitagliptin tablets, ensure seamless transition under guidance. Research supports its role in reducing cardiovascular events in high-risk patients, but individual results vary.

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Frequently Asked Questions (FAQs):

Q. What is Dapavel S 10/100 Tablet used for?

A. Dapavel S 10/100 Tablet is used to treat type 2 diabetes in adults by lowering blood sugar levels through a combination of dapagliflozin and sitagliptin, helping prevent complications when diet and exercise aren't sufficient.

Q. Are there any serious side effects of Dapavel S 10/100 Tablet?

A. While most side effects are mild, serious ones like ketoacidosis or severe infections can occur; watch for symptoms such as nausea, rapid breathing, or persistent pain and seek medical help immediately.

Q. Can I take Dapavel S 10/100 Tablet with other diabetes medicines?

A. Yes, but it may increase hypoglycemia risk with insulin or sulfonylureas, so your doctor will monitor and adjust doses accordingly.

Q. How long does it take for Dapavel S 10/100 Tablet to work?

A. Improvements in blood sugar can be seen within weeks, with full benefits like HbA1c reduction typically evident after 3 months of consistent use.

Q. Is Dapavel S 10/100 Tablet safe for long-term use?