Zepoxin 40 mg Injection

Zepoxin Injection Overview:

Zepoxin Injection is prescribed for the treatment of heartburn and acid indigestion associated with gastroesophageal reflux disease (GERD). Acid reflux or GERD is a common digestive condition nowadays, where stomach acid backs up into the esophagus (food pipe), causing a burning sensation in the chest (known as heartburn), and discomfort from indigestion when the acid irritates the stomach lining or throat. If left untreated, this condition can damage the esophagus due to excessive acid. By reducing stomach acid production, Zepoxin Injection helps alleviate symptoms and supports the healing and prevention of gastric and duodenal ulcers. Zepoxin Injection plays a vital role in managing acid-related digestive disorders, ensuring long-term relief.

Composition of Zepoxin Injection:

Each vial Zepoxin Injection contains: Pantoprazole Sodium (as Sterile Lyophilized Bulk) equivalent to Pantoprazole 40 mg.

Combipack with one 10 ml ampoule of Sodium Chloride Injection (0.9% w/v).

Uses and Benefits of Zepoxin Injection:

Zepoxin Injection is commonly prescribed for the following conditions:

• Reducing stomach acid production to alleviate symptoms associated with Gastroesophageal Reflux Disease (GERD) such as heartburn, indigestion, a sour taste in the mouth, pain and difficulty in swallowing.
• Healing peptic ulcers
• Providing relief from hyperacidity symptoms such as stomach pain and discomfort.
• Treating Zollinger-Ellison Syndrome, a condition where the stomach overproduces acid.

In combination with antibiotics, Zepoxin Injection helps treat Helicobacter pylori bacterial infections.

How Zepoxin Injection Works:

Zepoxin Injection contains the active ingredient Pantoprazole. Pantoprazole belongs to the group of medicines called, Proton Pump Inhibitor (PPI) that works by blocking the proton pump in the stomach lining, which is responsible for producing gastric acid. By inhibiting this enzyme, it effectively reduces stomach acid production, helping to treat conditions like GERD, acid reflux, and peptic ulcers.

Dosage of Zepoxin Injection:

• Usage Direction

Zepoxin Injection is intended for intravenous use only and must be administered by a healthcare professional. Reconstitute with 10 ml of Sodium Chloride Injection (0.9% w/v) provided free in this pack and use immediately after preparation. Do not attempt to self-administer this medication. Your doctor will determine the appropriate dosage based on your medical condition and how you respond to treatment.
Do not stop or alter the dose of Zepoxin Injection without consulting your doctor, as this may prevent you from achieving the desired result.

• Missed Dose

If you miss a dose of Zepoxin Injection, take it as soon as it is remembered. If it is time for your next dose of Zepoxin Injection, skip the missed dose and resume your regular schedule. Avoid taking two doses to compensate for a missed one.

• Overdose

If you accidentally take Zepoxin Injection more than your prescribed dose, seek immediate medical attention, as this may lead to serious side effects.

Contraindications of Zepoxin Injection:

If you are allergic to pantoprazole or any of its ingredients, do not take Zepoxin Injection. It should also be avoided if you are allergic to any other proton pump inhibitors, antibiotics, or any antiviral medication (atazanavir, or nelfinavir), or if you have cirrhosis, severe liver disease, or kidney disease.

Precautions & Warnings of Zepoxin Injection:

Before starting Zepoxin Injection, inform your doctor if you have jaundice, severe liver or kidney problems, or if you are at risk of low vitamin B12 levels and are receiving long term treatment with pantoprazole. Also, let your doctor know if you have a history of gastric ulcers or gastrointestinal surgery, or if you are taking HIV protease inhibitors like atazanavir. Additionally, notify your doctor if you have been on pantoprazole for more than 4 or more weeks or if you have experienced any skin reactions in the past.

Side Effects of Zepoxin Injection:

Zepoxin Injection may also cause some side effects, most of which do not require medical attention and typically go away as your body adapts to the medication. These may include headache, nausea, vomiting, gas, joint pain, diarrhea, and dizziness. However, if these side effects persist, consult your doctor as soon as possible. Some of the side effects may also be serious and may need medical attention such as: blistering, peeling, or bleeding skin, irregular or rapid heartbeat, muscle spasms, severe diarrhea with watery stools, changes in urination, blood in the urine, or worsening joint pain.

Safety Related Concerns of Zepoxin Injection:

• Pregnancy

If you are planning to become pregnant or if a pregnancy is discovered, it's important to consult with your doctor to determine whether it is safe for you to continue with Zepoxin Injection.

• Breastfeeding

Breastfeeding mothers are advised to avoid Zepoxin Injection as it may pass through breast milk and can cause side effects in breastfed babies. So, it is important to consult your doctor before taking Zepoxin Injection while breastfeeding.

• Alcohol

Although no direct interaction has been found between Zepoxin Injection and alcohol, but alcohol can increase stomach acid which can irritate your stomach lining and worsen acid reflux, as well as increase the risk of side effects such as dizziness and irregular heartbeat. Therefore, it is recommended to avoid alcohol during treatment with Zepoxin Injection.

• Food or Interactions with Other Medicines

While taking Zepoxin Injection, avoid spicy or junk foods, citrus fruits (like oranges, lemons, and grapefruits), acidic foods (such as tomatoes), and high-fat foods. Additionally, cut down on caffeinated drinks like coffee and tea and carbonated beverages (soda), as they may irritate your stomach.

Consult your doctor if you are taking any herbal products or supplements while taking Zepoxin Injection. As always, please consult your doctor or healthcare provider about your specific dietary needs while on Zepoxin Injection.

• Driving

If you experience side effects such as dizziness or blurred vision, you should avoid driving or operating machinery while taking Zepoxin Injection.

Storage Instructions of Zepoxin Injection:

Store below 25°C., protected from light.

Keep Zepoxin Injection out of reach of children.

Note: Eating smaller, more frequent meals, chewing your food slowly and properly, along with maintaining a healthy diet and managing your weight, can help improve your condition.

Frequently Asked Questions (FAQS) about Zepoxin Injection:

1. What is the use of Zepoxin Injection?

Zepoxin Injection is prescribed for the treatment of conditions caused by too much stomach acid, such as GERD, acid reflux, stomach ulcers, and Zollinger-Ellison syndrome. It works by reducing the amount of acid produced in your stomach. This helps relieve symptoms and promotes healing of the stomach lining, preventing further damage.

2. Which is better, Zepoxin Injection or Pan D?

The choice between Zepoxin Injection and Pan D depends on your specific condition. Zepoxin Injection contains Pantoprazole and is used primarily for treating acid-related issues like acid reflux and GERD. On the other hand, Pan D combines Pantoprazole with Domperidone, which not only reduces stomach acid but also helps with gastric motility and prevents nausea. Your doctor will recommend the most suitable medication based on your symptoms and needs.

3. Is Zepoxin Injection an antacid?

No, Zepoxin Injection is not an antacid. It contains pantoprazole, which belongs to a class of medications called proton pump inhibitors (PPIs). Zepoxin Injection works by stopping the production of acid in the stomach lining, resulting in long lasting relief from conditions like GERD, acid reflux, peptic ulcers, heartburn and indigestion. On the other hand, antacids are made from compounds like calcium carbonate, aluminum hydroxide, magnesium hydroxide and sodium bicarbonate. These ingredients neutralize the existing stomach acid, providing quick but short term relief from symptoms like heartburn, duodenal, and gastric ulcers, etc.

4. Which is better for acidity- Rantac 150 and Zepoxin Injection?

Both Rantac 150 and Zepoxin Injection are effective in managing acidity-related issues, but they serve slightly different purposes based on the severity of the condition. Rantac 150 contains ranitidine, which is typically suitable for mild or occasional acidity. On the other hand, Zepoxin Injection contains pantoprazole, which is more appropriate for frequent, chronic, or severe acid-related problems due to its longer lasting effect and stronger acid suppression. However, the choice between Rantac 150 and Zepoxin Injection should always depend on the individual’s specific health condition, the severity of symptoms, and how they respond to treatment. Please consult your healthcare professional before making any changes to your current medication.

References:

1. CDSCO. Pantoprazole. Click Here

2. MedlinePlus. Pantoprazole. Click Here

3. Pantoprazole Sandoz. Pantoprazole (as sodium sesquihydrate) enteric coated tablets. Consumer Medicine Information. Click Here

4. NHS. Pantoprazole -Brand name: Pantoloc Control. Click Here

5. Package leaflet: Information for the user. Pantoprazole 20mg Gastro-resistant Tablets. Pantoprazole (as sodium sesquihydrate). Click Here

6. Gallo, S., Dibildox, M., Moguel, A., Di Silvio, M., Rodríguez, F., Almaguer, I., & García, C. (1998). Superioridad clínica del pantoprazol sobre la ranitidina en la curación de la esofagitis por reflujo grado II y III. Estudio prospectivo, doble ciego, doble placebo. Experiencia clínica mexicana Grupo Mexicano de Estudio del Pantoprazol [Clinical superiority of pantoprazole over ranitidine in the treatment of reflux esophagitis grade II and III. A prospective, double-blind, double-placebo study. Mexican clinical experience. Mexican Pantoprazole Study Group]. Revista de gastroenterologia de Mexico, 63(1), 11–16. Click Here