Pentate D Tablet (10 Tab)

• Pentate D Tablet Overview:

Pentate D Tablet is used for the treatment of GERD (gastroesophageal reflux disease), indigestion, and gastritis in which stomach acid flows back into the food pipe, leading to heartburn and possible esophageal injury. Pentate D Tablet is composed of two main ingredients; Pantoprazole and Domperidone, is used in patients in which pantoprazole alone cannot control acid reflux. Pantoprazole reduces stomach acid production, while Domperidone helps improve stomach movement and prevents nausea. Together, they effectively manage acid reflux, heartburn, stomach pain, peptic ulcers, and other symptoms caused by hyper-acidity.

Composition of Pentate D Tablet:

Each enteric coated Pentate D Tablet contains: Pantoprazole Sodium equivalent to Pantoprazole 20 mg, Domperidone 10 mg and Excipients q.s.

Colours: Ponceau 4R & Titanium Dioxide.

• Uses and Benefits of Pentate D Tablet:

Pentate D Tablet is prescribed for the following conditions:

Manages Gastroesophageal Reflux Disease (GERD/Acid Reflux), where stomach acid backs up into the esophagus, leading to heartburn and irritation.

Relieves bloating, discomfort, and acid-related indigestion by reducing stomach acid production.

Reduces heartburn caused by acid reflux.

Eases gastritis caused by excess stomach acid or Helicobacter pylori bacterial infection.

Heals peptic ulcers by lowering stomach acid levels.

Provides relief from symptoms of acidity and hyperacidity, such as stomach pain, irritation, and discomfort.

• How Pentate D Tablet Works:

Pentate D Tablet contains two active ingredients, Pantoprazole and Domperidone, that work together to treat conditions caused by too much stomach acid and improve digestion.

Pantoprazole is a selective Proton Pump Inhibitor (PPI) that works by blocking the proton pump in the stomach lining, which is responsible for producing gastric acid. By inhibiting this enzyme, it effectively reduces stomach acid production, lowering acidity and helping to treat conditions like GERD, acid reflux, and peptic ulcers.

Domperidone, on the other hand, is a gastro-prokinetic and anti-nausea drug. It works by blocking dopamine receptors in the upper part of the digestive system, helping food move through the stomach and preventing nausea and vomiting.

• Dosage of Pentate D Tablet:

Usage Direction

Take Pentate D Tablet exactly as prescribed by your doctor, and follow the recommended dosage and schedule. Pentate D Tablet should be swallowed as whole without crushing, chewing, or breaking it, and ideally at the same time each day. Do not stop or alter the dose of Pentate D Tablet without consulting your doctor, as this may prevent you from achieving the desired outcome. Ask your doctor or pharmacist to explain any administration procedures you do not understand.

Missed Dose

If you miss a dose of Pentate D Tablet, take it as soon as it is remembered. If it is time for your next dose of Pentate D Tablet, skip the missed dose and resume your regular schedule. Avoid taking two doses to compensate for a missed one.

Over Dose

If you accidentally take Pentate D Tablet more than your prescribed dose, seek immediate medical advice, as this may lead to serious side effects.

• Contraindications of Pentate D Tablet:

Do not take Pentate D Tablet if you are allergic to Pantoprazole, Domperidone, or any other ingredients of this medication, or if you have severe kidney disease.

Pentate D should be avoided in patients with a prolactin-releasing pituitary tumor (prolactinoma), gastrointestinal problems, severe liver disease, stomach or intestinal bleeding, heart failure, or abnormal levels of potassium or magnesium in the blood.

• Precautions & Warnings of Pentate D Tablet:

Before starting Pentate D Tablet, inform your doctor if you have jaundice, severe liver or kidney problems, or if you are at risk of low vitamin B12 levels and are receiving long-term treatment with pantoprazole. Also, let your doctor know if you have a history of gastric ulcers or gastrointestinal surgery, or if you are taking HIV protease inhibitors like atazanavir. Additionally, notify your doctor if you have been on pantoprazole for more than 3 months or if you have experienced any skin reactions in the past.

• Side Effects of Pentate D Tablet:

Pentate D Tablet may cause some side effects, most of which do not require medical attention and typically go away as your body adjusts to the medication. However, if these effects persist, consult your doctor. These may include; headache, diarrhea or constipation, nausea or vomiting, abdominal pain or discomfort, gas, dry mouth, and dizziness. To help manage these, drink plenty of water, avoid foods that may cause gas, eat fiber-rich foods, and rest if you experience lightheadedness.

• Safety Related Concerns of Pentate D Tablet:

Pregnancy

If you are pregnant or planning to become pregnant, consult your doctor to determine if Pentate D Tablet is safe for you to take.

Breastfeeding

Breastfeeding mothers are advised to avoid Pentate D Tablet as it may pass through breast milk and can cause side effects in breastfed babies. Therefore, it is important to consult your doctor before taking Pentate D Tablet while breastfeeding.

Alcohol

Although no direct interaction between Pentate D and alcohol has been found, but alcohol can increase stomach acid, worsen acid reflux, and increase the risk of side effects such as dizziness and irregular heartbeat. Therefore, it's advisable to avoid alcohol while undergoing treatment.

Food or Interactions with Other Medicines

Avoid spicy or junk foods, citrus foods (Like oranges, lemons, grapefruits, acidic foods (tomatoes), high-fat foods, carbonated drinks (soda) while taking Pentate D Tablet.

Consult your doctor if you are taking any herbal products or supplements while taking Pentate D Tablet. As always, it is a good idea to consult your doctor or healthcare provider about your specific dietary needs while on Pentate D Tablet.

Driving

If you experience side effects such as dizziness or blurred vision, you should avoid driving or operating machinery while taking Pentate D Tablet.

• Storage Instructions of Pentate D Tablet:

Store protected from moisture, at a temperature not exceeding 25°C.

Keep Pentate D Tablet out of reach of children.

Note: Eating smaller, more frequent meals and maintaining a healthy diet can help improve your condition.

Frequently Asked Questions (FAQs) about Pentate D Tablet:

1. What is Pentate D Tablet used for?

Pentate D Tablet is used to manage conditions such as gastroesophageal reflux disease (GERD), acid reflux, peptic ulcers, and indigestion. It works by lowering stomach acid production, which helps alleviate symptoms like heartburn and discomfort. Additionally, it enhances gastric motility, promoting better digestion. This combination helps in providing relief from acid-related conditions and improving overall digestive health.

2. What is the ideal time to take Pentate D Tablet – before food or after food?

Take Pentate D Tablet with or without food, as recommended by your doctor based on your condition. However it is usually recommended to be taken before food, preferably 30 minutes to 1 hour prior to a meal. This helps the medication work better by lowering stomach acid before food arrives in the stomach. Always follow your doctor's instructions regarding timing for the best results.

3. Can Pentate D Tablet be taken daily?

Typically Pentate D Tablet can be taken daily preferably on an empty stomach, but the exact dosage may vary depending on your condition. It is important to follow your doctor’s advise and never take more than the recommended dose.

4. Which is better, Pentate D or Pan 40?

The choice between Pan 40 and Pentate D depends on your specific condition. Pan 40 contains Pantoprazole and is used primarily for treating acid-related issues like acid reflux and GERD. On the other hand, Pentate D combines Pantoprazole with Domperidone, which not only reduces stomach acid but also helps with gastric motility and prevents nausea. Your doctor will recommend the most suitable medication based on your symptoms and needs.

5. Are there any specific dietary restriction while taking Pentate D Tablet?

Yes, while using Pentate D Tablet, it’s recommended to avoid spicy, oily, or fatty foods, as well as caffeine-containing beverages like coffee and tea, carbonated drinks, and acidic foods such as citrus fruits and vegetables. For better dietary guideline, consult a registered dietitian or physician who can provide personalized guidance based on your specific condition.

6. Is Pentate D Tablet safe for gastritis treatment?

Pentate D Tablet may be used to treat gastritis, depending on the underlying cause and severity of the condition. It contains Pantoprazole, which reduces stomach acid production, and Domperidone, which aids in gastric motility and helps alleviate nausea and bloating. If gastritis is caused by excessive stomach acid or delayed gastric emptying, Pentate D can help by addressing both issues.

References:

1. Package leaflet: Information for the user Pantoprazole & Domperidone gastro-resistant Tablets (20 mg + 10 mg) PANSA D. Accessed on 18.03.2025. Click Here

2. Prescribing Information. Brand Name: P-RD® Capsules. Last Revised: February, 2023. Accessed on 18.03.2025. Click Here

3. Prescribing Information Leaflet. QPDOM. Accessed on 18.03.2025. Click Here

4. Prescribing Information Leaflet. PANSPED D. Last Revised: June 2020. Accessed on 18.03.2025. Click Here