Nolgliptin MF 1000 ER Tablet (10 Tab)

Nolgliptin MF 1000 ER Tablet Overview:

Nolgliptin MF 1000 ER Tablet is a prescription medication specifically designed for the management of Type 2 diabetes mellitus. This combination therapy is particularly effective for diabetic patients who do not respond adequately to single-agent therapy. This medication improves glycaemic control in diabetic patients who do not react well to Metformin alone. The tablet represents an ad`vanced approach to diabetes management, combining two proven antidiabetic mechanisms to achieve optimal blood sugar control while maintaining patient safety and convenience.

Composition:

Each uncoated bilayered tablet contains: Teneligliptin Hydrobromide Hydrate equivalent to Teneligliptin 20 mg, Metformin Hydrochloride (In Extended Release form) 1000 mg.

Colour: Ferric Oxide Yellow.

Uses & Benefits of Nolgliptin MF 1000 ER Tablet:

Nolgliptin MF 1000 ER Tablet offers multiple therapeutic advantages for Type 2 diabetes management. The primary benefit lies in its dual-action mechanism that addresses different aspects of glucose metabolism simultaneously. Patients experience improved glycemic control with reduced risk of hypoglycemic episodes compared to insulin therapy.

The combination therapy provides enhanced insulin sensitivity, reduced hepatic glucose production, and improved pancreatic beta-cell function. Additionally, the medication may contribute to modest weight management, which is particularly beneficial for overweight diabetic patients. The extended-release formulation ensures consistent blood sugar control throughout the day, reducing the frequency of blood sugar spikes and dips.

How Nolgliptin MF 1000 ER Tablet Works:

Metformin acts by decreasing liver glucose production and intestinal glucose uptake. On the other hand, Teneligliptin increases insulin secretion and decreases glucagon release. The dual mechanism approach ensures comprehensive glucose control through multiple pathways.

Metformin, belonging to the biguanide class, primarily works by reducing hepatic glucose production and improving insulin sensitivity in peripheral tissues. It also decreases intestinal glucose absorption, contributing to overall glucose homeostasis. Teneligliptin, as a DPP-4 inhibitor, prevents the breakdown of incretin hormones GLP-1 and GIP, which naturally regulate blood sugar by stimulating insulin release and inhibiting glucagon secretion in a glucose-dependent manner.

Dosage of Nolgliptin MF 1000 ER Tablet:

• Usage Directions

Nolgliptin MF 1000 ER Tablet should be taken exactly as prescribed by your healthcare provider. The extended-release formulation should be swallowed whole and never crushed, chewed, or broken, as this can affect the controlled-release mechanism.

It is essential to take the medication at the same time each day to maintain consistent blood levels. The timing should be coordinated with meals to optimize absorption and reduce stomach upset. Patients should continue taking the medication even if they feel well, as diabetes management requires consistent treatment to prevent long-term complications.

• Missed Dose

If you miss a dose of Nolgliptin MF 1000 ER Tablet, take it as soon as you remember, provided it is not too close to your next scheduled dose. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Never take a double dose to compensate for a missed one, as this may increase the risk of side effects, particularly hypoglycemia.

• Overdose

An overdose of Nolgliptin MF 1000 ER Tablet requires immediate medical attention. Symptoms of overdose may include severe hypoglycemia, lactic acidosis (particularly due to the metformin component), nausea, vomiting, stomach pain, and in severe cases, loss of consciousness or coma.

Nolgliptin MF 1000 ER Tablet may cause 'lactic acidosis' (accumulation of lactic acid in the blood), which can be life-threatening. If overdose is suspected, contact emergency medical services immediately. Treatment typically involves supportive care, glucose administration for hypoglycemia, and in cases of lactic acidosis, possible dialysis may be required.

Contraindications of Nolgliptin MF 1000 ER Tablet:

Nolgliptin MF 1000 ER Tablet is contraindicated in several specific conditions. Do not take this tablet if you are allergic to any of its contents. Do not use this medicine if you have heart failure, bladder cancer, or diabetic ketoacidosis.

Additional contraindications include severe renal impairment, severe hepatic dysfunction, acute or chronic metabolic acidosis, and conditions predisposing to lactic acidosis. Acute alcohol intoxication, hepatic dysfunction, and alcoholism (as a result of the metformin component) are also contraindications due to increased risk of lactic acidosis.

Precautions & Warnings of Nolgliptin MF 1000 ER Tablet:

Several important warnings must be considered when using Nolgliptin MF 1000 ER Tablet. The risk of lactic acidosis, though rare, is a serious concern, particularly in patients with kidney or liver problems. Regular monitoring of renal function is essential, especially in elderly patients or those with pre-existing kidney conditions.

Before taking Nolgliptin MF 1000 ER Tablet, inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have low potassium levels. Patients should be aware of signs and symptoms of lactic acidosis including unusual muscle pain, trouble breathing, stomach pain, dizziness, and feeling cold or tired.

Side Effects of Nolgliptin MF 1000 ER Tablet:

Common side effects of Nolgliptin MF 1000 ER Tablet include gastrointestinal disturbances such as nausea, vomiting, diarrhea, abdominal pain, and metallic taste. Common side effects may include nausea, abdominal pain, and diarrhoea. These effects are usually mild and tend to improve as the body adjusts to the medication.

More serious but less common side effects may include lactic acidosis, severe hypoglycemia when combined with other antidiabetic medications, allergic reactions, and vitamin B12 deficiency with long-term use. Patients should monitor for signs of low blood sugar including sweating, shakiness, rapid heartbeat, and confusion. Any persistent or severe side effects should be reported to healthcare providers immediately.

Pregnancy & Breastfeeding

The safety of Nolgliptin MF 1000 ER Tablet during pregnancy and breastfeeding has not been fully established. It is not recommended during pregnancy unless explicitly prescribed by a physician. Generally, this medication is not recommended during pregnancy as insulin is the preferred treatment for gestational diabetes management.

For breastfeeding mothers, the decision to use this medication should involve careful consideration of the benefits to the mother versus potential risks to the nursing infant. Both metformin and teneligliptin may pass into breast milk, though the clinical significance is not well established. Healthcare providers should evaluate alternative treatment options for pregnant or breastfeeding women with diabetes.

Alcohol Interaction:

Alcohol consumption should be limited or avoided while taking Nolgliptin MF 1000 ER Tablet. Alcohol can increase the risk of lactic acidosis, particularly due to the metformin component. Additionally, alcohol can affect blood sugar levels unpredictably, potentially causing either hypoglycemia or hyperglycemia.

If alcohol consumption is necessary, it should be done in moderation and with food to minimize blood sugar fluctuations. Patients should monitor their blood sugar more frequently when consuming alcohol and be aware of the symptoms of both high and low blood sugar. Regular heavy alcohol consumption is a contraindication for this medication.

Using Machinery & Driving:

Nolgliptin MF 1000 ER Tablet may affect your ability to drive or operate machinery, primarily due to the risk of hypoglycemia. Low blood sugar can cause dizziness, confusion, blurred vision, and reduced reaction times, making driving or operating heavy machinery dangerous.

Patients should be particularly cautious when starting the medication or when doses are adjusted. It is advisable to monitor blood sugar levels before driving, especially during the initial treatment period. If you experience any symptoms of low blood sugar, avoid driving and treat the hypoglycemia immediately according to your healthcare provider's instructions.

Food Interactions:

Patients should maintain a consistent, balanced diet as recommended by their healthcare provider or dietitian. Sudden changes in carbohydrate intake can affect blood sugar levels and may require dosage adjustments. Grapefruit and grapefruit juice should be avoided as they may interact with the medication's metabolism.

Consult your doctor if you are taking any herbal products, supplements, or other medicines while taking Nolgliptin MF 1000 ER Tablet. As always, please consult your doctor or healthcare provider about your specific dietary needs while on Nolgliptin MF 1000 ER Tablet.

Drug Interactions:

Several medications can interact with Nolgliptin MF 1000 ER Tablet, potentially affecting its efficacy or increasing the risk of side effects. Drugs that may increase the risk of lactic acidosis include alcohol, certain antibiotics, and medications affecting kidney function. Contrast agents used in imaging studies can temporarily affect kidney function and may require temporary discontinuation of the medication.

Other antidiabetic medications, corticosteroids, diuretics, and certain blood pressure medications may affect blood sugar control and require dose adjustments. Patients should inform all healthcare providers about their use of Nolgliptin MF 1000 ER Tablet before starting any new medications, including over-the-counter drugs and supplements.

Storage Instructions of Nolgliptin MF 1000 ER Tablet:

Store in a cool, dry & dark place.

Keep the medication out of reach of children. Check expiration dates regularly and dispose of expired medications safely according to local guidelines. Never share your medication with others, even if they have similar symptoms.

Other Notes

Regular monitoring is essential while taking Nolgliptin MF 1000 ER Tablet. Patients should maintain regular follow-up appointments with their healthcare provider to assess treatment effectiveness and adjust dosages as needed.

Do not stop taking Zita Met Plus 20/500 tablet without asking your doctor. Because the treatment of diabetes is lifelong. Lifestyle modifications, including regular exercise, proper diet, and weight management, remain crucial components of diabetes treatment alongside medication therapy.

Related Blood Glucose Monitors:

To manage diabetes at home, discover our simple, reliable home-use Blood Glucose Monitoring systems with Test Strips. Check Out

Frequently Asked Questions (FAQs):

Q: How long does it take for Nolgliptin MF 1000 ER Tablet to show results?

A: Most patients begin to see improvements in blood sugar levels within 1-2 weeks of starting treatment. However, the full therapeutic effect may take 2-3 months to achieve. Regular blood sugar monitoring will help track your progress.

Q: Can I take Nolgliptin MF 1000 ER Tablet if I have kidney problems?

A: This medication is not recommended for patients with severe kidney impairment. Your doctor will assess your kidney function through blood tests before prescribing this medication and monitor it regularly during treatment.

Q: What should I do if I experience stomach upset with this medication?

A: Taking the tablet with food can significantly reduce stomach-related side effects. If problems persist, consult your healthcare provider who may adjust your dose or recommend additional measures to minimize discomfort.

Q: Is it safe to exercise while taking Nolgliptin MF 1000 ER Tablet?

A: Yes, regular exercise is encouraged and beneficial for diabetes management. However, monitor your blood sugar before and after exercise, as physical activity can lower blood glucose levels. Carry glucose tablets in case of hypoglycemia.

Q: Can I take this medication with other diabetes drugs?

A: Nolgliptin MF 1000 ER Tablet can be used with other diabetes medications, but this requires careful medical supervision to prevent hypoglycemia and ensure optimal blood sugar control. Always inform your doctor about all medications you're taking.

Q: What are the signs of low blood sugar I should watch for?

A: Signs of hypoglycemia include sweating, shakiness, rapid heartbeat, hunger, confusion, dizziness, and irritability. If you experience these symptoms, check your blood sugar immediately and treat according to your healthcare provider's instructions.

Q: Are there any dietary restrictions while taking Nolgliptin MF 1000 ER Tablet?

A: While there are no absolute dietary restrictions, maintaining a consistent, balanced diet as recommended by your healthcare provider is important. Limit alcohol consumption and avoid sudden changes in carbohydrate intake that could affect blood sugar levels.