Nexito Plus Tablet (10 Tab)

Nexito Plus Tablet Overview:

Nexito Plus Tablet is a combination medication containing escitalopram and clonazepam, commonly prescribed for the management of anxiety disorders and depression.

Escitalopram works as an antidepressant that helps improve mood and emotional balance, while Clonazepam acts as an anti-anxiety medicine that calms excessive brain activity. Together, they help reduce nervousness, fear, restlessness, and emotional distress by stabilizing overactive nerve signals in the brain, promoting a sense of calm and mental well-being.

It is usually prescribed when a single medicine is not enough to control symptoms or when anxiety is more severe and requires treatment through two different mechanisms.

Nexito Plus Tablet should always be taken under the supervision of a healthcare professional, as the dose and duration are carefully tailored based on individual symptoms, medical history, and treatment response. Always consult your doctor before starting or adjusting this medication to ensure safe and effective use.

Composition:

Each film coated tablet contains- Escitalopram Oxalate equivalent to Escitalopram: 5 mg, Clonazepam: 0.5 mg and Excipients q.s.

Colours: Ferric Oxide (Red) and Titanium Dioxide.

Uses & Benefits of Nexito Plus Tablet:

• Used in the treatment of anxiety disorders, such as generalized anxiety disorder (GAD) and social anxiety disorder.
• Helps relieve symptoms of major depressive disorder (MDD), associated with anxiety
• Reduces the frequency and intensity of panic attacks and panic-related symptoms
• Aids in improving sleep disturbances and insomnia linked to anxiety and mood disorders

In some cases, it is also used as supportive therapy for managing symptoms of obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD), under medical supervision.

How does Nexito Plus Tablet Work:

Nexito Plus Tablet works through a dual mechanism of action using its two active ingredients, escitalopram and clonazepam, which work together to manage anxiety effectively.

Escitalopram works by increasing serotonin levels in the brain, a natural chemical that helps control mood, emotions, and anxiety. By blocking the reuptake (reabsorption) of serotonin, escitalopram allows more serotonin to remain in brain circuits that control mood and anxiety. Clonazepam, on the other hand, enhances the activity of GABA, a neurotransmitter that reduces excessive brain activity and produces a calming effect.

This dual mechanism not only targets the root causes of mood disorders but also provides rapid symptom relief, making the combination more effective for treatment-resistant cases than either ingredient alone.

Dosage of Nexito Plus Tablet:

• Usage Direction

Take Nexito Plus Tablet strictly according to your doctor’s instructions, following the prescribed dose and timing. Swallow the tablet of Nexito Plus whole without crushing, chewing, or breaking it, preferably at the same time each day. Do not stop or alter the dose of Nexito Plus Tablet without consulting your doctor, as this may prevent you from achieving the desired outcome. If you are unsure about the administration procedures of Nexito Plus, consult with your doctor or pharmacist.

• Missed Dose

If you miss a dose of Nexito Plus Tablet, take it as soon as you remember on the same day. However, skip the missed dose and stick to your regular dosing schedule if your next scheduled dose is almost due. Never take two doses to make up for a missed one because this could cause your blood pressure to drop too much. If you frequently forget to take your medication, consider setting reminders on your phone, using a pill organizer, or linking medication intake to a daily routine activity like meals or bedtime. Taking the medication regularly helps keep steady levels in the body and ensures the best treatment results.

• Overdose

If you accidentally take Nexito Plus Tablet more than your prescribed dose, seek immediate medical advice, as this may lead to serious side effects. Signs of overdose may include extreme drowsiness, confusion, slowed breathing, or even loss of consciousness. Seek emergency help by calling your local poison control center or heading to the nearest hospital.

Contraindications of Nexito Plus Tablet:

Nexito Plus Tablet should not be used if you have a known hypersensitivity to escitalopram, clonazepam, or any related compounds, as this could trigger severe allergic reactions like rash or swelling. It should not be used in individuals with acute narrow-angle glaucoma, severe liver disease, or those currently taking monoamine oxidase inhibitors (MAOIs) for depression, due to risks of dangerous interactions. Patients with a history of substance abuse or certain respiratory conditions should avoid it, as should those with bipolar disorder unless stabilized on other therapies. Patients with a history of severe depression with suicidal ideation should be carefully evaluated before prescribing this medication. Always disclose your full medical history to your doctor to rule out these incompatibilities before starting treatment.

Precautions & Warnings of Nexito Plus Tablet:

Nexito Plus Tablet should be used with caution and only under medical supervision. Before starting Nexito Plus, tell your doctor about all your medical conditions, including any history of seizures, bipolar disorder, schizophrenia, or suicidal thoughts. Those with kidney or mild liver impairment should have their doses adjusted, while severe cases may require alternatives. Monitor closely for any worsening of mood or emergence of suicidal thoughts, especially during the first few weeks of treatment. Do not stop the medicine suddenly, as withdrawal symptoms such as anxiety, tremors, insomnia, or seizures may occur, dose reduction should always be gradual. Always inform your doctor about all medical conditions and medicines you are taking.

Side Effects of Nexito Plus Tablet:

Nexito Plus Tablet may cause some side effects, most of which are mild and usually disappear as your body adjusts to the medication. However, if these symptoms continue, it is important to consult your doctor. Common side effects include drowsiness, dizziness, fatigue, confusion, difficulty concentrating, and impaired coordination. Less frequent but notable side effects might involve gastrointestinal symptoms such as nausea, vomiting, diarrhea, constipation, or dry mouth, etc. Sexual side effects, such as reduced libido or delayed orgasm, occur in some users due to the escitalopram. Rare but serious issues like irregular heartbeat, severe allergic reactions, or mood worsening warrant immediate medical consultation. Report any persistent or troubling symptoms to your doctor for personalized management strategies.

Safety Related Concerns of Nexito Plus Tablet:

• Pregnancy

Nexito Plus Tablet is generally not recommended during pregnancy, as both escitalopram and clonazepam can cross the placenta and may affect fetal development. If you are pregnant or planning to become pregnant while taking this medication, do not stop it suddenly without medical advice, as abrupt discontinuation can also be harmful. It is important to discuss the potential risks and benefits with your healthcare provider so that the safest treatment plan can be decided for both you and your baby.

• Breastfeeding

Both escitalopram and clonazepam may pass into breast milk. Elecitalopram exposure through breast milk is generally low, but infants should be monitored for sleepiness, agitation, poor feeding, and poor weight gain. Clonazepam can also reach breast milk and may cause sedation or breathing issues in infants. Discuss breastfeeding options with your healthcare provider to determine the safest plan.

• Alcohol

Alcohol should be strictly avoided while taking Nexito Plus Tablet, as it can cause serious interactions. Combining alcohol with this medicine may lead to excessive drowsiness, deep sedation, poor judgment, loss of coordination, slowed reaction time, and a higher risk of accidents. Alcohol can also worsen side effects such as dizziness, confusion, and difficulty concentrating. If you have issues in avoiding alcohol during treatment, talk to your doctor to ensure safe use of the medication.

• Using Machinery & Driving

Nexito Plus Tablet can cause drowsiness, dizziness, blurred vision and impaired concentration, which are critical abilities required for safe driving and machinery operation. Do not drive or operate machinery until you understand how this medication affects your alertness.

• Food Interactions

There are no specific foods that must be strictly avoided while taking Nexito Plus Tablet.

Maintaining consistent eating habits and timing of medication relative to meals can help establish a routine and improve medication adherence.

A balanced, nutritious diet can support overall mental health and complement the therapeutic effects of the medication.

• Drug Interactions

Nexito Plus Tablet may interact with certain medicines, which can affect how it works or increase side effects. These include MAO inhibitors such as linezolid, moclobemide, and selegiline. Other antidepressants, migraine medicines, opioids, sleeping pills, anti-anxiety drugs, and muscle relaxants may cause excessive drowsiness or breathing problems when used together. Blood thinners, pain relievers like aspirin or NSAIDs, and herbal products such as St. John’s Wort may increase the risk of bleeding or serotonin-related side effects.

Consult your doctor if you are taking any herbal products, supplements or other medicines while taking Nexito Plus Tablet. As always, please consult your doctor or healthcare provider about your specific dietary needs while on Nexito Plus Tablet.

Storage Instructions of Nexito Plus Tablet:

Store at a temperature not exceeding 25°C. Protected from light and moisture.

Do not use Nexito Plus Tablet past its expiration date printed on the package. Dispose of expired or unused medications properly according to local guidelines or take them to a pharmacy take-back program. Keep all medicines out of reach of children.

Additional Notes:

Take the tablet exactly as prescribed by your doctor.

Inform your doctor about all other medicines, supplements, or herbal products you use.

Attend regular follow-ups so your doctor can monitor response, side effects, and dose needs.

Seek medical advice promptly if you notice mood changes, increased anxiety, unusual behavior, or thoughts of self-harm.

Immediately inform your doctor if you notice mood changes, increased anxiety, unusual behavior, or thoughts of self-harm.

Maintain healthy sleep habits and follow lifestyle advice given by your healthcare provider.

Do not take other anxiety, sleep, or antidepressant medicines without medical advice.

Do not share your medicine with others, even if symptoms seem similar.

Frequently Asked Questions (FAQs):

Q1. What is Nexito Plus Tablet used for?

A: Nexito Plus Tablet is used to treat anxiety disorders, panic attacks, and depression associated with anxiety. The combination of escitalopram and clonazepam helps calm the mind, reduce excessive worry and fear, and improve emotional balance.

Q2. Is Nexito Plus Tablet habit-forming?

A: Yes, the clonazepam in this medicine can become habit-forming with long use. Your body might get used to it and need it to feel normal. Always take only what your doctor prescribes. Do not take more pills, take them more often, or share with anyone. Your doctor will give you the exact amount that works for the shortest time needed.

Q3. Can Nexito Plus Tablet be taken with other antidepressants?
A: No, it should not be combined with other antidepressants or MAO inhibitors unless your doctor specifically advises it. Taking them together can cause a dangerous condition called serotonin syndrome with confusion, fast heartbeat, fever, and seizures. Wait 14 days between stopping one medicine and starting another. Tell your doctor about every medicine and supplement you take to stay safe.

Q4. Can Nexito Plus Tablet be stopped suddenly?

A: No, never stop taking this medicine suddenly, even when feeling better. Sudden discontinuation can trigger severe withdrawal symptoms, including anxiety, tremors, sweating, confusion, and seizures. Stopping the medicine suddenly can lead to serious withdrawal symptoms such as increased anxiety, shaking, sweating, confusion, and even seizures. Always ask your doctor before changing anything about your medicine.

Q5. Does Nexito Plus Tablet cause sleepiness or drowsiness?

A: Yes, this medicine can make you feel sleepy, dizzy, or tired, especially when you first start taking it. Don't drive or use machines until you see how it affects you. The sleepy feeling usually gets better after a few weeks. If you stay very tired, tell your doctor. They might change when you take it or adjust your dose.

Q6. Can I drink alcohol while taking Nexito Plus Tablet?

A: No, never drink alcohol with this medicine. Mixing them makes you extremely sleepy, clumsy, and can cause dangerous breathing problems. Alcohol also makes your anxiety and depression worse. Ask your pharmacist if you're unsure about any product.

Q6. Can Nexito Plus Tablet be taken at night?

A: Yes, Nexito Plus Tablet can be taken at night, and in many cases, it is a preferred option due to the sedating effects of its clonazepam component, which helps promote better sleep for those with anxiety-related insomnia. Always follow your doctor's specific guidance, as they may recommend timing based on your individual response.