Martifur MR 100 mg Tablet (10 Tab)

Martifur MR 100 mg Tablet Overview:

Martifur MR 100 mg Tablet is an antibiotic used to treat and prevent certain bacterial infections of the urinary tract, including bladder infections such as cystitis. It contains Nitrofurantoin, which has bactericidal activity against susceptible bacteria that cause urinary tract infections (UTIs).

Nitrofurantoin acts mainly in the urinary tract, where it forms active compounds that damage essential bacterial processes, including protein and genetic material production. This helps kill the bacteria and clear the infection. Martifur MR 100 mg Tablet is effective against several common UTI-causing bacteria, including Escherichia coli and Staphylococcus saprophyticus. It may help relieve symptoms such as burning or pain during urination, frequent urination, and urinary discomfort.

Urinary tract infections can affect different parts of the urinary system, including the bladder, kidneys, and other areas. Martifur MR 100 mg Tablet works only against bacterial infections and should not be used for viral illnesses such as the common cold or flu.

Composition:

Each uncoated modified release tablet contains- Nitrofurantoin: 100 mg and Excipients q.s.

Uses & Benefits of Martifur MR 100 mg Tablet:

Martifur MR 100 mg Tablet is indicated for the following conditions:

Urinary Tract Infections (UTIs): Treats bacterial bladder infections (cystitis) caused by susceptible strains of Escherichia coli, Enterococcus faecalis, Staphylococcus saprophyticus, and Klebsiella species.

Prophylaxis of Recurrent UTIs: Used for long-term prevention in individuals prone to frequent, recurrent urinary infections or following urinary tract procedures or catheterization.

How Does Martifur MR 100 mg Tablet Work:

Martifur MR 100 mg Tablet contains Nitrofurantoin, an antibacterial agent belonging to the nitrofuran class. Its mode of action is distinct from other antimicrobials.

Nitrofurantoin is rapidly absorbed and concentrated directly in the urine, precisely targeting the lower urinary tract. Inside bacterial cells, bacterial enzymes (nitrofuran reductases) reduce nitrofurantoin into highly reactive intermediate compounds. These active intermediates attack and damage bacterial ribosomal proteins, DNA, RNA, and metabolic enzyme systems, effectively inhibiting vital biochemical processes and leading to bacterial cell death.

Dosage of Martifur MR 100 mg Tablet:

• Usage Directions

Take Martifur MR 100 mg Tablet strictly according to your doctor’s instructions, following the prescribed dose and timing. Martifur MR 100 mg Tablet should be swallowed whole with water and not chewed, cut, or crushed, preferably at the same time each day. Do not stop or alter the dose of Martifur MR 100 mg Tablet without consulting your doctor, as this may prevent you from achieving the desired outcome. If you aren't sure how to take Martifur MR 100 mg, check with your healthcare provider or pharmacist for instructions.

• Missed Dose

If you miss a dose of Martifur MR 100 mg Tablet, take it as soon as you remember on the same day. If it's almost time for your dose, skip the missed dose and proceed with your usual routine. Do not take a double dose if you have forgotten one.

To help remember your daily dose, set phone alarms, use a pill organizer box, or use medication reminder apps.

• Overdose

If you accidentally take Martifur MR 100 mg Tablet more than your prescribed dose, seek immediate medical advice or contact a poison control center. An overdose may cause vomiting.

Contraindications of Martifur MR 100 mg Tablet:

Do not take Martifur MR 100 mg Tablet if you have a known allergy or hypersensitivity to Nitrofurantoin, other nitrofuran derivatives, or any inactive component present in this medication.

It must not be used by patients with significant renal impairment or severe kidney dysfunction, as the drug cannot be cleared effectively.

Additionally, it is strictly contraindicated in individuals with acute porphyria, Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency, infants under 3 months of age, and pregnant individuals in the final trimester or during labor and delivery.

Precautions & Warnings of Martifur MR 100 mg Tablet:

Before taking Martifur MR 100 mg Tablet, consult a healthcare provider and discuss your complete medical history. Inform your physician if you have diabetes, vitamin B deficiency, anemia, liver disease, lung disorders, renal impairment, or conditions causing severe physical weakness.

Additionally, acute or chronic pulmonary reactions, such as cough, shortness of breath, chest pain, or pulmonary fibrosis, can occur, particularly during long-term therapy. Peripheral neuropathy (nerve damage causing numbness or tingling in the hands and feet) is another potential risk. If neurological or respiratory symptoms arise, stop taking Martifur MR 100 mg immediately.

For patients undergoing prolonged prophylactic regimens, periodic clinical monitoring of lung function, liver enzymes, and kidney health is strongly advised.

Side Effects of Martifur MR 100 mg Tablet:

Like all medicines, Martifur MR 100 mg Tablet can cause side effects, although not everyone will experience them. Common side effects may include nausea, vomiting, loss of appetite, mild stomach upset, headache, dizziness, and brownish or dark yellow discoloration of urine (a harmless byproduct of the drug).

However, you should seek immediate medical attention if you experience any rare or serious adverse reactions, such as allergic skin rashes or hives, shortness of breath, a persistent cough, chest pain, fever, chills, numbness or tingling in the hands and feet (peripheral neuropathy), joint pain and swelling, severe headaches, or signs of liver problems like yellowing of the skin or eyes (jaundice).

Safety Related Concerns of Martifur MR 100 mg Tablet:

• Pregnancy

If you are pregnant or planning to become pregnant, talk to your doctor before taking this medication to weigh the benefits against potential risks to the developing baby. Use Martifur MR 100 mg Tablet during early and mid-pregnancy only when prescribed by a healthcare provider. It is strictly contraindicated at term or during labour and delivery due to the potential risk of red blood cell breakdown (haemolytic anaemia) in the newborn.

• Breastfeeding

Avoid Martifur MR 100 mg Tablet while breastfeeding, since Nitrofurantoin passes into breast milk in trace amounts, which could affect the breastfed child. Consult your healthcare provider before taking Martifur MR 100 mg Tablet while nursing.

• Alcohol

There is no direct interaction between Martifur MR 100 mg Tablet and alcohol. However, it is advisable to avoid alcohol consumption as it may cause bladder irritation, dehydration, and can worsen side effects like nausea or dizziness.

• Food Interactions

Martifur MR 100 mg Tablet may be taken with or without food as advised by your physician, though taking it after meals is generally recommended to increase its bioavailability and reduce gastric discomfort.

• Drug Interactions

Martifur MR 100 mg Tablet may interact with other medicines, either by compromising their effectiveness or increasing the risk of adverse side effects. Antacids containing magnesium trisilicate significantly reduce the absorption of nitrofurantoin and should be avoided.

Uricosuric medications like probenecid and sulfinpyrazone decrease the urinary excretion of the drug, which lowers its efficacy while increasing systemic toxicity in the blood.

Additionally, medications that make urine alkaline (such as potassium citrate mixtures and acetazolamide) reduce its antibacterial potency, while anticholinergic drugs like atropine and hyoscine can alter its absorption.

Nitrofurantoin may also antagonize quinolone antibiotics and reduce the efficacy of live oral vaccines, such as the typhoid vaccine.

Always provide your doctor with a complete list of all prescription medications, over-the-counter products, and supplements before starting treatment.

• Using Machinery & Driving

Martifur MR 100 mg Tablet may cause dizziness or drowsiness. Patients should be cautious or avoid driving or operating machinery until they are sure the medication does not affect their alertness.

Storage of Martifur MR 100 mg Tablet:

Store in a cool, dry, and dark place. Protect from light & moisture. Keep out of reach of children.

Do not take this medication after the expiration date printed on the package. It is important to dispose of expired or unused medications properly; do not throw them away casually.

Helpful Tips:

• Drink plenty of fluids (at least 2–3 liters of water daily) to help flush bacteria out of the urinary tract.
• Urinate regularly and completely; avoid holding urine for extended periods, and void immediately after sexual intercourse.
• Limit bladder irritants such as excess caffeine, acidic beverages, alcohol, and spicy foods during an active infection.
• Complete the full antibiotic course prescribed by your healthcare provider, even if symptoms subside early, to prevent bacterial resistance.
• Continue taking your medication as prescribed, and do not discontinue it abruptly without your doctor's advice.
• Never share your medicine with others, even if they have similar symptoms, because this is a prescription drug tailored specifically for you.

Frequently Asked Questions (FAQs):

Q: What is the use of Martifur MR 100 mg Tablet?

A: Martifur MR 100 mg Tablet is primarily used to treat and prevent acute or recurrent uncomplicated lower urinary tract infections (UTIs), such as bladder infections (cystitis). It works by eliminating common bacteria causing the infection directly within the urinary tract.

Q: How does Martifur MR 100 mg Tablet help prevent recurrent UTIs?

A: Martifur MR 100 mg Tablet prevents recurrent urinary tract infections by maintaining a steady, low-level antibacterial concentration directly in the bladder urine. This continuous suppression stops bacteria (such as E. coli) from multiplying or adhering to the bladder wall before a full infection can develop, all while targeting the urinary tract with minimal disruption to healthy gut bacteria.

Q: Why has my urine turned dark yellow or brown after taking Martifur MR 100 mg Tablet?

A: This is a common and completely harmless side effect caused by the natural breakdown and excretion of Nitrofurantoin in your urine. It does not mean your infection is getting worse or that there is blood in your urine, and the colour will return to normal once you finish your prescribed course.

Q: How quickly will Martifur MR 100 mg Tablet relieve my UTI symptoms?

A: Most patients notice an improvement in symptoms (such as reduced pain and burning while urinating) within 24 to 48 hours, though the exact duration is influenced by the clinical severity of your condition and your individual physiological response to therapy. However, you must complete the entire course prescribed by your doctor to ensure all bacteria are eliminated and prevent the infection from returning.

Q: Is Martifur MR 100 mg Tablet effective for kidney infections?

A: No. Nitrofurantoin concentrates heavily in the bladder urine and does not reach high enough levels in kidney tissue. Therefore, it is only indicated for lower urinary tract infections (cystitis) and is not suitable for upper urinary tract or kidney infections (pyelonephritis).

Q: What should I do if I experience breathing difficulty or a persistent cough while taking this medicine?

A: Stop taking the medication immediately and contact your doctor. In rare cases, Nitrofurantoin can cause inflammatory lung reactions (pulmonary toxicity). Symptoms like sudden shortness of breath, chest pain, fever, chills, or a persistent dry cough require prompt medical evaluation.

References:

1. NITROFURANTOINE Tablets – 100 mg (Nitrofurantoin). PACKAGE LEAFLET: Information for the user. Last Revised: September 2023. Accessed on: 10th September 2026. Click Here

2. Nitrofurantoin 50mg and 100mg Capsules, Hard nitrofurantoin. Package leaflet: Information for the user. Last Revised: April 2026. Accessed on: 10th September 2026. Click Here

3. NITROFURANTOIN 50 mg & 100 mg TABLETS. PACKAGE LEAFLET: INFORMATION FOR THE USER. Last Revised: January 2017. Accessed on: 10th September 2026. Click Here

4. Nitrofurantoin BNM. Full CMI. Last Revised: June 2023. Accessed on: 10th September 2026. Click Here