Jitovilda ME 50/500 Tablet (10 Tab)

Jitovilda ME 50/500 Tablet Overview:

Jitovilda ME 50/500 Tablet is a combination oral antidiabetic medicine used to control blood sugar levels in adults with type 2 diabetes mellitus.

This condition, also known as non-insulin-dependent diabetes mellitus, occurs when the body does not produce enough insulin or is unable to use it effectively. If left untreated, it may lead to serious complications such as cardiovascular disease, kidney damage, nerve disorders, vision problems, and delayed wound healing.

Jitovilda ME 50/500 Tablet contains vildagliptin and metformin, which work through complementary mechanisms to improve glycemic control. Vildagliptin enhances glucose-dependent insulin secretion, while metformin reduces hepatic glucose production and improves insulin sensitivity. This combination is particularly beneficial when lifestyle modifications, such as diet and exercise, or single-drug therapy do not provide adequate blood glucose control.

Additionally, Jitovilda ME 50/500 Tablet is indicated for use in combination with insulin, as an adjunct to diet and exercise, to improve glycemic control in adult patients who are not adequately controlled with a stable dose of insulin and metformin alone.

Composition:

Each film coated tablet contains- Vildagliptin: 50 mg and Metformin Hydrochloride: 500 mg.

Colours: Titanium Dioxide, Ferric Oxide Yellow and Ferric Oxide Red.

Uses & Benefits of Jitovilda ME 50/500 Tablet:

Jitovilda ME 50/500 Tablet is indicated for the treatment of type 2 diabetes mellitus in adults in following situations:

• As initial therapy in patients whose blood glucose is not adequately controlled by diet and exercise alone
• In patients whose diabetes is not adequately controlled with metformin HCl alone, or those already receiving vildagliptin and metformin as separate tablets
• As part of combination therapy, including with insulin or other antidiabetic agents, when existing treatment does not achieve adequate glycemic control

How Does Jitovilda ME 50/500 Tablet Work:

Jitovilda ME 50/500 Tablet utilizes a dual-action formula, combining two distinct antidiabetic agents Vildagliptin and Metformin.

Vildagliptin belongs to a group called DPP-4 inhibitors. It works by blocking the DPP-4 enzyme, thereby increasing the levels of incretin hormones. These hormones stimulate the pancreas to release more insulin in response to elevated blood glucose (especially after meals) and reduce glucagon secretion, which in turn decreases excess glucose production by the liver.

At the same time, metformin a biguanide, lowers the amount of sugar the liver produces, helps the body’s cells use insulin more efficiently, and slightly reduces sugar absorption from food in the intestines. Together, vildagliptin and metformin in Jitovilda ME 50/500 Tablet give balanced blood sugar control throughout the day without putting extra strain on the pancreas.

Dosage of Jitovilda ME 50/500 Tablet:

• Usage Direction

Take Jitovilda ME 50/500 Tablet strictly according to your doctor’s advice, following the prescribed dose and timing. Jitovilda ME 50/500 Tablet should be swallowed whole with water without crushing, chewing, or breaking it, preferably at the same time each day. Do not stop or alter the dose of Jitovilda ME 50/500 Tablet without consulting your doctor, as this may prevent you from achieving the desired outcome. If you are unsure about the administration procedures of Jitovilda ME 50/500 Tablet consult with your doctor or pharmacist.

• Missed Dose

If you miss a dose of Jitovilda ME 50/500 Tablet, take it as soon as you remember on the same day. But, if it is almost time for your next scheduled dose, skip the one you missed and continue following your regular dosing schedule. Do not attempt to take two doses if you have forgotten one. If you often forget to take your medication, consult with your doctor to re-evaluate your dosing schedule. Frequently missing doses could lead to undesired outcomes.

You can set reminders on your smartphone, keep drug organizer boxes, or use other audio-visual technologies to prevent missing a dose.

• Overdose

If you accidentally take more than the prescribed dose of Jitovilda ME 50/500 Tablet, you must seek immediate medical attention or contact an emergency room. An overdose can lead to life-threatening conditions, most notably Lactic Acidosis (a buildup of acid in the bloodstream due to Metformin) or Hypoglycemia (severely low blood sugar). Symptoms of overdose may include severe vomiting, stomach pain, muscle cramps, or extreme tiredness.

Contraindications of Jitovilda ME 50/500 Tablet:

Do not take Jitovilda ME 50/500 Tablet if you are hypersensitive or allergic to Vildagliptin, Metformin, or any of its ingredients.

This medicine is contraindicated in patients those with diabetic ketoacidosis or diabetic pre-coma. It should not be used in patients with renal impairment or renal failure (creatinine clearance < 60 mL/min), or in acute conditions that may affect kidney function, such as dehydration, severe infection, shock, or following the administration of iodinated contrast agents. This combination is also contraindicated in conditions associated with tissue hypoxia, including cardiac or respiratory failure, recent myocardial infarction, and shock. Additionally, it should be avoided in patients with hepatic impairment and in those with acute alcohol intoxication or chronic alcoholism.

Precautions & Warnings of Jitovilda ME 50/500 Tablet:

Before starting Jitovilda ME 50/500 Tablet, it is vital to provide your healthcare provider with a complete medical history. Inform your doctor if you have any pre-existing liver, kidney, or heart conditions, or a history of pancreatitis. Special caution is also required if you are prone to hypoglycemia (low blood sugar) or have persistent skin disorders, as Vildagliptin has been associated with rare cases of skin lesions. To ensure safety, your doctor will likely perform regular blood tests to monitor your kidney and liver function throughout your treatment.

A primary concern with the Metformin component is the rare but life-threatening risk of lactic acidosis. This risk increases with kidney impairment, excessive alcohol intake, or severe infection. Furthermore, be vigilant for signs of a severe allergic reaction, such as difficulty breathing or swallowing, swelling of the face or throat, chest tightness, or widespread hives. If you experience any of these symptoms, or unexplained muscle pain and extreme weakness, seek immediate medical assistance.

Additionally, patients scheduled for medical imaging (such as CT scans) involving iodinated contrast dye must inform their radiologist. The medicine should be stopped 48 hours before surgery or procedures involving iodinated contrast and restarted only after kidney function is confirmed to be normal.

Side Effects of Jitovilda ME 50/500 Tablet:

Jitovilda ME 50/500 Tablet may cause certain side effects, most of which are mild and temporary as the body adjusts to the medication. Commonly reported symptoms include gastrointestinal disturbances such as nausea, vomiting, diarrhea, abdominal pain, flatulence, and heartburn. Patients may also experience neurological or systemic effects, including tremors, headaches, dizziness, hypoglycemia (low blood sugar), fever, an itchy skin rash, and joint pain. These common reactions are often manageable and tend to subside with consistent use, particularly when the medication is taken with food to "buffer" the stomach.

However, it is essential to consult a healthcare professional immediately if you experience more serious adverse reactions that could indicate an underlying complication. Critical symptoms to watch for include signs of lactic acidosis (such as extreme weakness or difficulty breathing), pancreatitis (severe, persistent abdominal pain radiating to the back), or liver impairment, which may manifest as yellowing of the skin or eyes (jaundice) and dark-colored urine. Early detection of these serious symptoms is vital for preventing long-term health issues.

Safety Related Concerns of Jitovilda ME 50/500 Tablet:

• Pregnancy

The safety of using Jitovilda ME 50/500 Tablet during pregnancy is not known. Generally, it is not recommended during pregnancy, unless the benefits outweigh the risk factors. Your doctor may switch you to a safer alternative, such as insulin, to maintain proper blood sugar control.

Careful and regular blood glucose monitoring during pregnancy is essential to reduce the risk of complications and support healthy fetal development. Always follow your doctor’s advice and do not start or stop any diabetes medication without medical guidance.

• Breastfeeding

It is better to avoid the use of the Jitovilda ME 50/500 Tablet while breastfeeding, since it is unknown whether the active ingredients of this medicine could pass into the breast milk and affect the breastfed child. Therefore, consulting with your doctor before taking Jitovilda ME is crucial.

• Alcohol

Avoid alcohol consumption while taking Jitovilda ME 50/500 Tablet, as it may increase the risk of lactic acidosis and can cause unpredictable fluctuation in blood sugar levels.

• Food Interactions

The interaction between specific food items and the Jitovilda ME 50/500 Tablet is not listed. To minimize gastrointestinal side effects, it can be taken with food. However, maintaining a healthy diabetic diet is essential to regulate blood glucose levels, which can be achieved by avoiding high-glycemic-index foods, sugary items, and refined carbohydrates, while limiting high-fat items, as these are primarily responsible for glucose spikes. Prioritizing a balanced diet rich in soluble fiber and essential vitamins not only supports more stable blood sugar readings but also improves overall metabolic health and long-term cardiovascular outcomes.

• Drug Interactions

Jitovilda ME 50/500 Tablet can interact with a wide range of medications, which may either compromise its blood-sugar-lowering effectiveness or increase the risk of serious side effects. Certain drugs, such as corticosteroids, diuretics (water pills), and beta-2 agonists (often found in asthma inhalers), can counteract the medication's action and lead to elevated blood glucose levels. Conversely, the concomitant use of NSAIDs (common pain relievers like Ibuprofen) or ACE inhibitors (blood pressure medications) with the Metformin component can increase renal stress, potentially elevating the risk of lactic acidosis.

Always inform your healthcare provider and pharmacist about all medications you are taking, including prescription drugs, over-the-counter medications, vitamins, minerals, and herbal supplements, to avoid potential interactions.

• Using Machinery & Driving

Using Jitovilda ME 50/500 Tablet may affect your ability to drive or operate machinery, it can cause low blood sugar (hypoglycemia), which may lead to symptoms like blurred vision, dizziness, shaking, or sweating. If you feel unwell or dizzy, then avoid driving or such activities.

Storage of Jitovilda ME 50/500 Tablet:

Store protected from moisture, at a temperature not exceeding 30°C. Keep out of reach of children. Avoid using it after the expiry date, printed on the packaging. Dispose of expired or unused medication properly; do not throw it away casually.

Additional Information:

• Maintain a consistent exercise routine and a "diabetic diet" (low glycemic index foods and high fiber).
• Limit sugary snacks, such as pastries, chocolates, sweet beverages and refined carbohydrates.
• Check your blood sugar levels regularly to see how the medication is working, or as directed by your doctor.
• Diabetics should check their feet daily for sores or infections.
• Regular monitoring of blood sugar levels at home, or as directed by your doctor.
• Make sure to have quick sugar supplies on hand for low blood sugar episodes.
• Do not suddenly stop your medication unless your doctor specifically tells you to.
• Do not share your medicine with someone else having the same symptoms as you.

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Frequently Asked Questions (FAQs):

Q. What is Jitovilda ME 50/500 Tablet used for?

A. Jitovilda ME 50/500 Tablet is primarily used to treat type 2 diabetes mellitus in adult patients, especially when diet, exercise, and single therapy are insufficient. It works by reducing the sugar produced by the liver, increasing insulin production in the pancreas, and improving the body's sensitivity to insulin.

Q. Can I stop taking Jitovilda ME 50/500 Tablet if my blood sugar is normal?

A. No, because diabetes is a chronic condition. Stopping medication without consulting a doctor can lead to dangerous sugar spikes.

Q. Is it safe to take Jitovilda ME 50/500 Tablet on an empty stomach?

A. It is highly recommended to take Jitovilda ME 50/500 Tablet with food to prevent stomach discomfort and diarrhea. However, always follow the prescribed dose of you physician to obtain effective results.

Q. What should I do if I feel shaky, sweaty, or dizzy?

A. The above mentioned signs indicates hypoglycemia (low blood sugar), which can happen if you skip a meal or exercise intensely. Always keep a source of fast-acting sugar, like glucose tablets, fruit juice, or hard candy, nearby to treat these symptoms immediately.

Q. Can Jitovilda ME 50/500 Tablet cause weight loss?

A. No, unlike some other anti-diabetic drugs, Metformin is often weight-neutral or may lead to slight weight loss in some patients. However, if you notice significant weight loss, it is essential to consult your doctor right away.

Reference:

1. Galvus Met. Leaflet. Novartis. Last Revised: July 2020. Accessed on: 27th March 2026. Click Here

2. Vilget M. Vildagliptin + Metformin HCl. Accessed on: 27th March 2026. Click Here