Jitotel AMHZ 40/5/12.5 Tablet (10 Tab)

Jitotel AMHZ 40/5/12.5 Tablet Overview:

Jitotel AMHZ 40/5/12.5 Tablet is a specialized medication designed specifically for managing hypertension, or high blood pressure, in patients who require more than a single or dual therapy approach to achieve effective blood pressure control. As a form of triple-drug therapy, it combines three powerful components to address the complexities of elevated blood pressure, which can silently strain the heart, blood vessels, and kidneys over time. Jitotel AMHZ 40/5/12.5 Tablet is particularly useful for individuals whose hypertension remains uncontrolled despite lifestyle changes or simpler treatments, helping to lower the risks of heart attacks, strokes, and kidney problems associated with uncontrolled hypertension. By targeting multiple pathways involved in blood pressure regulation, Amlopres Trio promotes smoother cardiovascular function and supports long-term heart health, making it a go-to option for comprehensive hypertension management under medical supervision. Regular monitoring by a healthcare provider is essential to ensure it fits individual health needs.

Composition:

Each uncoated bilayered tablet contains: Telmisartan 40 mg, Amlodipine Besilate equivalent to Amlodipine 5 mg, and Hydrochlorothiazide 12.5 mg, Excipients q.s.

Colour: Brilliant Blue FCF.

Use & Benefits of Jitotel AMHZ 40/5/12.5 Tablet:

• Effective blood pressure control through triple-drug therapy often achieves greater reductions in systolic and diastolic pressures compared to dual therapies.
• Reduces risk of stroke by relaxing blood vessels and preventing excessive arterial strain.
• Lowers the chance of heart attack by easing the heart's workload and improving overall circulation.
• Helps prevent kidney problems in hypertensive patients by maintaining optimal renal blood flow and reducing proteinuria risks.

How Jitotel AMHZ 40/5/12.5 Tablet Works:

Jitotel AMHZ 40/5/12.5 Tablet operates through three distinct mechanisms to control blood pressure.

Amlodipine, a calcium channel blocker stops calcium from getting into the muscle cells around your blood vessels. This lets those muscles relax, widens the vessels, and makes it easier for your heart to pump blood without working so hard.

Telmisartan, an angiotensin receptor blocker blocks a hormone called angiotensin II from latching onto spots on your blood vessels that make them tighten and hold onto extra salt and water. By stopping this, vessels stay more open, and body gets rid of excess fluid more easily.

Hydrochlorothiazide, a thiazide diuretic works in your kidneys to flush out extra salt and water through urine, which shrinks the overall amount of fluid in your bloodstream and eases the pressure on your arteries.

Dosage of Jitotel AMHZ 40/5/12.5 Tablet:

• Usage Directions

To maximize the benefits of Jitotel AMHZ 40/5/12.5 Tablet for hypertension management, it is recommended to take the tablet orally, preferably at the same time each day, with or without food. Tablet should be swallowed whole with a full glass of water to ensure proper absorption and avoid any potential irritation to the throat. Do not crush or chew the tablet. Your doctor may monitor your blood pressure regularly and adjust it if needed, especially in the first few weeks. Team it up with easy habits like cutting back on salt, staying active with walks or workouts, and chilling out with relaxation tricks—these supercharge the medicine's power to cut your chances of stroke, heart trouble, or kidney issues.

• Missed Dose

If you miss a dose of Jitotel AMHZ 40/5/12.5 Tablet, take it as soon as you remember, provided it is not close to the time for your next scheduled dose. If it is close to your next dose, completely skip the forgotten dose and continue with your regular schedule. Do not take two tablets together, as this can increase side effects like dizziness or dehydration.

To keep your blood pressure under control, try taking your tablet at the same time every day or set a reminder on your phone. If you miss doses often or have skipped multiple doses, speak to your doctor so they can guide you on the safest next steps.

• Overdose

In the event of an overdose with Jitotel AMHZ 40/5/12.5 Tablet, seek immediate medical help immediately or call emergency services. An overdose can cause very low blood pressure, dehydration, or problems with the kidneys. Warning signs may include severe dizziness, fainting, a fast heartbeat, confusion, nausea, or passing a lot of urine followed by extreme thirst.
In the hospital, doctors usually give supportive treatment—such as IV fluids to raise blood pressure, checking electrolytes, and monitoring the heart. If the overdose was recent, they may use activated charcoal to reduce absorption.

Contraindications of Jitotel AMHZ 40/5/12.5 Tablet:

Jitotel AMHZ 40/5/12.5 Tablet must not be used by individuals with hypersensitivity or allergic reactions to any active ingredients—Amlodipine, Telmisartan, or Hydrochlorothiazide, or to similar medicines like other calcium channel blockers, ARBs, or thiazide-type diuretics. People with severe kidney failure, no urine output, or serious liver disease should not take it, as the body cannot clear the medicine safely. It is also unsafe in those with blocked bile ducts, severe electrolyte problems (like very low sodium or potassium), or adrenal gland disorders that have not been corrected.

People who have had angioedema (swelling of the face, lips, or throat) from ACE inhibitors or ARBs, or those with severe aortic stenosis or major heart-outflow problems, should also avoid Amlopres Trio due to the risk of dangerous blood pressure drops.

Precautions & Warnings of Jitotel AMHZ 40/5/12.5 Tablet:

Before starting Jitotel AMHZ 40/5/12.5 Tablet, regular blood tests to monitor kidney function, electrolytes (especially potassium and sodium), and liver enzymes are advised, particularly in the initial weeks, to catch any imbalances early. Patients with a history of gout should be cautious, as the thiazide diuretic may elevate uric acid levels, though the ARB component can offer some protective balance. Dehydration risk is heightened in hot weather or during intense exercise, so adequate fluid intake is vital. Those with diabetes need to watch blood sugar levels closely, as the diuretic might influence glycemic control. Inform your doctor if you experience persistent cough, swelling, or unexplained fatigue, as these could signal underlying issues. This medication supports blood pressure control but does not cure hypertension, so ongoing vigilance is necessary to reduce risks of stroke, heart attack, and kidney problems.

Side Effects of Jitotel AMHZ 40/5/12.5 Tablet:

Common side effects of Jitotel AMHZ 40/5/12.5 Tablet include dizziness, particularly when standing up quickly, ankle swelling or peripheral edema from the CCB action, nausea, and occasional visual disturbances like blurred vision. The diuretic component may increase dehydration risk, manifesting as dry mouth, thirst, or muscle cramps. Less frequent but notable effects can involve headache, fatigue, or a mild cough from the ARB. Most of these are mild and diminish over time as the body adjusts, but persistent or severe symptoms warrant medical review. Serious side effects, though rare, might include signs of low potassium (weakness, irregular heartbeat), allergic reactions (rash, itching, swelling), or kidney strain (reduced urine output). Research on similar combinations indicates good overall tolerability, with side effects often comparable to or lower than individual monotherapies.

Safety Related Concerns of Jitotel AMHZ 40/5/12.5 Tablet:

• Pregnancy

Jitotel AMHZ 40/5/12.5 Tablet is not recommended during pregnancy, as it can cause serious harm to the developing baby, including reduced kidney function, low amniotic fluid, lung underdevelopment, bone abnormalities, or even death. If pregnancy is detected while taking it, stop immediately and consult your doctor for safer alternatives. Women planning pregnancy should switch to other blood pressure medications with proven safety profiles.

Label Warning: When pregnancy is detected, Telmisartan should be discontinued as soon as possible as it can cause injury and even death to the developing fetus, when used during second and third trimester of pregnancy.

• Breastfeeding

Avoid breastfeeding while using Jitotel AMHZ 40/5/12.5 Tablet, as components like telmisartan and hydrochlorothiazide can pass into breast milk and potentially cause low blood pressure, high potassium, or kidney issues in the infant. Discuss with your doctor about stopping the medication or using formula if hypertension control is essential. No human data exists on its full effects during lactation, but animal studies suggest risks.

• Alcohol

Consuming alcohol with Jitotel AMHZ 40/5/12.5 Tablet can worsen side effects like dizziness or fainting due to enhanced blood pressure lowering. It may also aggravate orthostatic hypotension, where blood pressure drops upon standing. Limit or avoid alcohol, and rise slowly from sitting or lying positions to minimize risks. If you drink regularly, inform your doctor for possible adjustments.

• Using Machinery & Driving

Jitotel AMHZ 40/5/12.5 Tablet may cause dizziness or fatigue, especially when starting treatment or increasing the dose, which could impair your ability to drive or operate machinery. Avoid these activities until you know how the medication affects you. If you experience syncope (fainting) or vertigo, refrain from hazardous tasks and consult your healthcare provider. If visual disturbances occur, avoid driving altogether until resolved. If experiencing any of these symptoms while driving or operating machinery, stop the activity immediately and rest until completely recovered.

• Food Interactions

Jitotel AMHZ 40/5/12.5 Tablet can generally be taken with or without food, but avoid grapefruit or grapefruit juice, as it may increase amlodipine levels, leading to stronger blood pressure drops. High-potassium foods like bananas or salt substitutes should be monitored, as telmisartan might raise potassium levels. Hydrochlorothiazide could affect blood sugar, so diabetics should watch carbohydrate intake. No major restrictions otherwise, but a balanced, low-sodium diet enhances its effectiveness.

• Drug Interactions

Jitotel AMHZ 40/5/12.5 Tablet can interact with several medications, so inform your doctor about all drugs you're taking. NSAIDs like ibuprofen may reduce its antihypertensive effects and stress the kidneys. Potassium-sparing diuretics or supplements could lead to hyperkalemia when combined with the ARB. Lithium levels might rise with the diuretic, requiring monitoring. Beta-blockers or other antihypertensives can potentiate blood pressure lowering, risking hypotension. Avoid aliskiren in diabetic patients due to renal risks. Always provide a complete list of your current medications, including over-the-counter ones, to prevent adverse outcomes.

Storage Instructions:

Store Jitotel AMHZ 40/5/12.5 Tablet protected from light & moisture, at a temperature not exceeding 25°C. Keep out of reach of children. Keep it in its original pack and dispose of unused or expired tablets properly.

Important: Moisture sensitive tablet - do not remove from strip until immediately before administration.

Additional Notes:

• Monitor Your Blood Pressure Regularly
• Routine Blood Tests, kidney function tests, blood sugar, uric acid, lipid profile are Important
• Follow a Heart-Healthy Lifestyle containing fruits, vegetables, whole grains, and low-fat dairy products
• Reduce salt, oily foods, saturated fats, and added sugar
• Exercise regularly as advised by your doctor
• Quit smoking and limit alcohol intake
• Do not stop the medicine suddenly without medical advice.

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Frequently Asked Questions (FAQs):

Q1. What is Jitotel AMHZ 40/5/12.5 Tablet used for?

A. Jitotel AMHZ 40/5/12.5 Tablet is primarily used to treat hypertension or high blood pressure in adults when simpler treatments aren't enough, offering triple-drug therapy for better control and reduced risks of serious complications.

Q2. How soon can I expect Amlopres Trio to lower my blood pressure?

A. You may notice initial effects within 2 to 6 hours, but it often takes 1 to 2 weeks of daily use for the full blood pressure-lowering benefits to stabilize, making consistent dosing important.

Q3. Are there any serious Amlopres Trio side effects I should watch for?

A. Yes, watch for signs like severe dizziness, swelling, chest pain, or vision changes, and seek medical help if they occur, as they could indicate allergic reactions or electrolyte issues.

Q4. Is Amlopres Trio safe for long-term use?

A. Yes, it's generally safe for ongoing hypertension control with regular monitoring, as clinical trials show sustained benefits and good tolerability over time.

Q5. How soon can I expect Amlopres Trio to lower my blood pressure?

A. You may notice initial effects within 2 to 6 hours, but it often takes 1 to 2 weeks of daily use for the full blood pressure-lowering benefits to stabilize, making consistent dosing important.

Q6. Can I take Amlopres Trio if I have kidney issues?

A. It depends on the severity; mild issues may be okay with monitoring, but severe renal impairment is a contraindication due to the diuretic and ARB components—always get your doctor's approval first.

Q7. Does Amlopres Trio interact with my daily salt intake?

A. A low-salt diet works best alongside it to boost efficacy, as excess sodium can counteract the diuretic's fluid-reducing action and hinder blood pressure control.

Q8. Is it safe to stop Amlopres Trio suddenly?

A. No, abrupt stopping can cause rebound high blood pressure; taper under medical guidance to safely transition and maintain protection against stroke or heart risks.