Jitotam DU 0.4/0.5 Tablet (10 Tab)

Jitotam DU 0.4/0.5 Tablet Overview:

Jitotam DU 0.4/0.5 Tablet is a combination medicine used for the treatment of benign prostatic hyperplasia (BPH), a noncancerous enlargement of the prostate gland commonly seen in men. An enlarged prostate can press against the urethra, leading to troublesome urinary symptoms such as frequent urination, urgency, weak urine flow, difficulty starting urination, incomplete bladder emptying, and discomfort during or after urination.

BPH occurs due to increased or abnormal production of the male hormone dihydrotestosterone (DHT), which causes the prostate to grow over time. If left untreated, BPH may progress to acute urinary retention, a medical emergency where urine flow is completely blocked, and in severe cases, surgery may be required.

Jitotam DU 0.4/0.5 Tablet contains dutasteride and tamsulosin, which work together to manage BPH effectively. Dutasteride reduces DHT levels, helping shrink the prostate, while tamsulosin relaxes prostate and bladder muscles to improve urine flow. This dual action relieves symptoms, improves quality of life, and reduces the need for surgery.

Composition:

Each film coated tablet contains- Tamsulosin Hydrochloride (as sustained release): 0.4 mg, Dutasteride: 0.5 mg and Excipients q.s.

Colour: Indigo Carmine & Titanium Dioxide.

Uses & Benefits of Jitotam DU 0.4/0.5 Tablet:

Jitotam DU 0.4/0.5 Tablet helps manage the following symptoms:

• Improved urinary flow: The medication helps to improve urine flow by relaxing the smooth muscle in the prostate and bladder neck while reducing prostate size over time.

• Reduced urinary frequency: Patients experience fewer trips to the bathroom, particularly during nighttime hours.

• Relief from urgency: The urgent need to urinate is significantly diminished, improving quality of life.

• Decreased risk of acute urinary retention: The combination therapy reduces the likelihood of sudden inability to urinate, which often requires emergency medical intervention.

• Lower need for surgical intervention: Long-term use of Dutasteride and Tamsulosin to improve urine flow has been shown to reduce the need for BPH-related surgery.

How Jitotam DU 0.4/0.5 Tablet Works:

Jitotam DU 0.4/0.5 Tablet contains two active ingredients: Tamsulosin and Dutasteride, which work in different ways to treat Benign Prostatic Hyperplasia (BPH).

Dutasteride belongs to the group of medicines called 5-alpha reductase inhibitors that work by reducing the production of the hormone called dihydrotestosterone (DHT), which is responsible for prostate growth. By lowering DHT levels, Dutasteride reduces the size of the prostate and helps prevent it from getting larger, which relieves pressure on the bladder and improves urination over time.

Tamsulosin, on the other hand, relaxes the muscles in the prostate and bladder neck. This helps make urination easier and relieves symptoms like a weak urine stream, difficulty starting urination, and the frequent or urgent need to urinate.

Dosage of Jitotam DU 0.4/0.5 Tablet:

• Usage Directions

Take Jitotam DU 0.4/0.5 Tablet strictly according to the prescribed dose and time, as directed by your doctor. It is important to swallow Jitotam DU 0.4/0.5 Tablet whole without chewing, crushing or breaking it, especially at the same time every day, preferably 30 minutes after a meal. Do not stop or change the dosage of Jitotam DU 0.4/0.5 without consulting your doctor, as this may prevent you from achieving the desired results. If you are unsure about the method of administration of Jitotam DU 0.4/0.5, consult your doctor or pharmacist.

• Missed Dose

In case you missed a dose of Jitotam DU 0.4/0.5 Tablet, take it as soon as it is remember. If it is nearly time for your next dose of Jitotam DU 0.4/0.5, skip the missed dose and continue with your regular dosing plan. Avoid taking a double dose of Jitotam DU 0.4/0.5 to make up for a missed one.

If you miss doses for several consecutive days, contact your healthcare provider before resuming treatment.

• Overdose

If you accidentally take Jitotam DU 0.4/0.5 Tablet, seek immediate medical attention or contact a poison control center. Taking more than the prescribed one capsule of Jitotam DU 0.4/0.5 Tablet daily can lead to excessive relaxation of prostate muscles or lowered blood pressure, causing symptoms like severe dizziness, fainting, or rapid heartbeat. Supportive care, such as monitoring vital signs, may be needed, though no specific antidote exists. Preventive measures, like secure storage away from children, are crucial to avoid accidental excess.

Contraindications of Jitotam DU 0.4/0.5 Tablet:

Do not take Jitotam DU 0.4/0.5 Tablet if you are allergic or hypersensitive to tamsulosin, dutasteride, or any of the ingredients in this medication. Jitotam DU 0.4/0.5 Tablet should not be handled by women of childbearing potential or by children (not more than 18 years old) as Dutasteride can be absorbed through the skin. Jitotam DU 0.4/0.5 Tablet must not be used in men with severe liver impairment or ongoing orthostatic hypotension should discuss alternatives with their doctor. Always disclose your full medical history before starting.

Precautions & Warnings of Jitotam DU 0.4/0.5 Tablet:

Jitotam DU 0.4/0.5 Tablet, containing Dutasteride and Tamsulosin, is used to treat symptoms of an enlarged prostate. Certain precautions are important during treatment. This medicine may cause dizziness or low blood pressure, especially when starting therapy, so stand up slowly to avoid falls. Tamsulosin may affect cataract or glaucoma surgery by causing Intraoperative Floppy Iris Syndrome; inform your eye doctor if you use or have used this medicine.

If your partner is or may be pregnant, make sure you use a condom during intercourse, as dutasteride in this formulation may affect the normal development of a male baby.

Also, if you are a woman, child or an adolescent, you must avoid the leaked Jitotam DU 0.4/0.5 Tablet. In case contact is made, wash the affected area immediately with soap and water.

Side Effects of Jitotam DU 0.4/0.5 Tablet:

Common side effects include ejaculation problems, reduced libido, and erectile dysfunction. These effects are more frequent with combination therapy compared to either medicine alone. Other commonly reported side effects include dizziness, weakness, breast tenderness or enlargement, headache, runny nose, and back pain.

Serious side effects are uncommon but need urgent medical attention. These include severe dizziness or fainting, a painful erection lasting more than four hours, allergic reactions such as swelling of the face or throat, breathing difficulty, or serious skin reactions. Rare cases of mood changes, testicular pain, heart failure risk, and male breast cancer have been reported with long-term use.

Safety Related Concerns of Jitotam DU 0.4/0.5 Tablet:

• Pregnancy & Breastfeeding

Jitotam DU 0.4/0.5 Tablet must not be taken by women.

Label Warning:

Women who are or who may become pregnant must not handle crushed or broken Dutasteride tablets as they can be absorbed through skin & carry the risk of causing birth defects in the foetus. Also Dutasteride should not be taken by women who are breastfeeding.

• Alcohol

Alcohol can potentiate the blood pressure-lowering effects, potentially increasing the risk of dizziness, light-headedness, and orthostatic hypotension. The combination of alcohol with this medication may enhance the risk of falls and fainting episodes, particularly when standing up quickly. Patients should discuss alcohol consumption with their healthcare provider and be advised to moderate intake, especially during the initial treatment period when the body is adjusting to the medication. If alcohol is consumed, it should be done with awareness of increased risk for dizziness and postural blood pressure changes.

• Using Machinery & Driving

Jitotam DU 0.4/0.5 Tablet medication may affect your ability to operate machinery or drive vehicles safely. If you experience dizziness, light-headedness, or any symptoms that could impair your alertness or coordination, avoid driving and operating machinery until these effects subside. Patients should be especially cautious when getting up from a sitting or lying position, as sudden position changes can trigger dizziness.

• Food Interactions

There are no specific foods that must be avoided while taking Jitotam DU 0.4/0.5 Tablet, but maintaining a consistent routine regarding meal timing and medication administration improves treatment outcomes and helps patients remember to take their daily dose.

• Drug Interactions

Jitotam DU 0.4/0.5 Tablet should not be taken with strong CYP3A4 inhibitors such as ritonavir or ketoconazole, as they can increase drug levels and side effects. Medicines like erythromycin, verapamil, and diltiazem may also raise exposure and should be used carefully. Strong CYP2D6 inhibitors, including paroxetine, can increase Tamsulosin levels, while cimetidine may significantly raise its concentration. Using other alpha-blockers or erectile dysfunction medicines such as sildenafil or tadalafil can increase the risk of low blood pressure. Always inform your doctor about all medicines, supplements, and herbal products you use.

Storage Instructions:

Store protected from light and moisture at a temperature not exceeding 25°C.

Do not use Jitotam DU 0.4/0.5 Tablet past its expiration date printed on the package. Dispose of expired or unused medications properly according to local guidelines or take them to a pharmacy take-back program. Keep the medicine out of reach of children.

Additional Notes:

• Do not donate blood during treatment and for at least six months after stopping the medicine.

• Regular doctor visits are important to monitor symptom improvement and screen for prostate cancer.

• It may reduce semen volume or sperm count; discuss family planning with your doctor if needed.

• If doses are missed for several days, consult your doctor before restarting.

• Sexual side effects often stabilize over time; do not stop treatment without medical advice.

Frequently Asked Questions (FAQ):

Q1. What is Jitotam DU 0.4/0.5 Tablet used for?

A: Jitotam DU 0.4/0.5 Tablet is a combination medicine used for the treatment of benign prostatic hyperplasia (BPH), a noncancerous enlargement of the prostate gland commonly seen in men. An enlarged prostate can press against the urethra, leading to troublesome urinary symptoms such as frequent urination, urgency, weak urine flow, difficulty starting urination, incomplete bladder emptying, and discomfort during or after urination.

Q2. What are the side effects of Jitotam DU 0.4/0.5 Tablet?

A: Jitotam DU 0.4/0.5 Tablet may cause some common side effects and some uncommon side effects. Common side effects include impotence, decreased sexual desire, difficulty in ejaculation, breast enlargement or swelling (gynecomastia), dizziness and trouble sleeping (insomnia). If any of these symptoms continue or trouble you, consult your doctor. Unusual side effects include allergic reactions, fast heartbeat, diarrhea, constipation, vomiting, fatigue, low blood pressure, itching and a blocked or runny nose and which may also require immediate medical attention.

Q3. Can Jitotam DU 0.4/0.5 be taken for long-term use?

A: Yes, your doctor may prescribe you Jitotam DU 0.4/0.5 Tablet for long-term use, so that you can achieve the desired results. However, if any of the following problems bother you, such as dizziness, loss of libido, ejaculation problems, or breast tenderness, then follow up regularly with your doctor.

Q4. Jitotam DU 0.4/0.5 and Urimax 0.4, which one is better?

A: Both Urimax 0.4 and Jitotam DU 0.4/0.5 are used to treat Benign Prostatic Hyperplasia (BPH), but their composition and purpose are different. Urimax 0.4 contains only Tamsulosin, which is prescribed for the treatment of mild to moderate stages of BPH by relaxing the muscles of the prostate and bladder neck, improving the flow of urine. Meanwhile, Jitotam DU 0.4/0.5 is a combination of Tamsulosin and Dutasteride, which is prescribed during moderate to severe stages of BPH or when the prostate is significantly enlarged and is intended for long-term management, which not only relieves symptoms but also works to shrink the size of the prostate over time, by blocking the hormone responsible for its growth.

Your doctor will recommend the most appropriate medicine, depending on the severity of your condition and how well you tolerate this medicine.

Q5. Does Jitotam DU 0.4/0.5 Tablet cause frequent urination?

A: No, Jitotam DU 0.4/0.5 Tablet is not a diuretic and will not cause frequent urination. It is prescribed to treat Benign Prostatic Hyperplasia (BPH) and to reduce symptoms such as frequent or urgent urination. The tablet contains two active ingredients, Tamsulosin and Dutasteride, which work together to relax the muscles around the bladder neck and gradually shrink the enlarged prostate. This helps relieve pressure on the urethra and improves urine flow, ultimately reducing urinary symptoms rather than causing them.

Q6. What causes BPH, the condition Jitotam DU 0.4/0.5 Tablet is prescribed?

A: BPH, or benign prostatic hyperplasia, is a non-cancerous enlargement of the prostate gland. The normal size of an adult male prostate gland usually weighs 15 to 20 grams and measures approximately 3 cm x 4 cm x 2.5 cm, with a volume of less than 30 cc. When the prostate gland is enlarged, it can cause urinary problems such as difficulty starting to urinate, a weak stream, frequent urination, or a feeling that the bladder is not empty. However, the exact cause of BPH is not fully understood, with several factors believed to contribute, such as overproduction of the hormone testosterone and its more active form, dihydrotestosterone (DHT), ageing, and certain growth factors that can stimulate the proliferation of prostate cells, genetics, and lifestyle.

Reference:

1. DOUBLUTS 500 micrograms / 400 micrograms. Dutasteride 500 micrograms and tamsulosin HCl 400 micrograms. Consumer Medicine Information. Last Revised: August 2020. Accessed on 25.06.2025. Click Here

2. Mega Lifescience. Dutasteride 0.5 mg and Tamsulosin Hydrochloride 0.4 mg. Administrative Information and Product Description. Last Revised: July 2020. Accessed on 25.06.2025. Click Here

3. JALYN (dutasteride and tamsulosin hydrochloride) Capsules. Last Revised: June 2010. Accessed on 25.06.2025. Click Here

4. Package leaflet: Information for the user. Dutasteride/Tamsulosin hydrochloride Glenmark 0.5 mg/0.4 mg hard capsules. dutasteride/tamsulosin hydrochloride. Last Revised: December 2024. Accessed on 25.06.2025. Click Here

5. PATIENT INFORMATION LEAFLET. DUTASTERIDE TAMSULOSIN ADCO 0.5 mg / 0.4 mg, hard gelatine capsules Dutasteride / tamsulosin hydrochloride Sugar free. Last Revised: 08 August 2023. Accessed on 25.06.2025. Click Here