Jitosita ME 100/500 Tablet (10 Tab)

Jitosita ME 100/500 Tablet Overview:

Jitosita ME 100/500 Tablet is a combination oral anti-diabetic medication that helps control high blood sugar levels in adults with type 2 diabetes mellitus.

Type 2 diabetes mellitus is a non-insulin-dependent metabolic disorder that occurs when our body does not produce enough insulin or when the body cannot effectively use the insulin produced by the body, resulting in increased blood glucose levels. Type 2 diabetes can cause serious complications, such as heart attack and stroke, as well as kidney damage, nerve damage, vision problems, slow wound healing, etc.

Jitosita ME 100/500 Tablet is prescribed when lifestyle changes, such as diet, exercise, and previous treatment with an oral anti diabetic medicine, have failed to control blood sugar levels effectively.

Jitosita ME 100/500 Tablet plays an important role in the management of type 2 diabetes mellitus by increasing the body's response to insulin or increasing the body's production of insulin, thereby reducing the risk of its associated complications.

Composition:

Each uncoated bilayered tablet contains- Metformin Hydrochloride (As prolonged release form): 500 mg, Sitagliptin Phosphate Monohydrate Equivalent to Sitagliptin: 100 mg, and Excipients q.s.

Colour: Ferric Oxide Yellow.

Uses & Benefits of Jitosita ME 100/500 Tablet:

Jitosita ME 100/500 Tablet is prescribed for the treatment of Type 2 Diabetes or non-insulin-dependent diabetes mellitus (NIDDM).

By maintaining the blood sugar, it may also prevent other complications of diabetes such as stroke, heart attack, kidney failure, nerve damage, eye problems, and delay wound healing.

How Does Jitosita ME 100/500 Tablet Works:

Jitosita ME 100/500 Tablet contains Sitagliptin and Metformin, which work together to help control high blood sugar levels in people with type 2 diabetes.

Sitagliptin belongs to a group of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors or gliptins. It lowers blood sugar by blocking the DPP-4 enzyme, which breaks down incretin hormones. These incretins stimulate the body to produce more insulin and decrease sugar production by the liver after meals.

On the other hand, Metformin, belongs to a class of medicines called biguanides. Metformin works in Type 2 diabetes by decreasing glucose production in the liver and increasing the body's sensitivity to insulin, which helps lower blood sugar levels.

Dosage Of Jitosita ME 100/500 Tablet:

• Usage Direction

Take Jitosita ME 100/500 Tablet, strictly according to the prescribed dose and time, as directed by your doctor. Jitosita ME 100/500 Tablet should be swallowed whole without chewing, crushing or breaking it, especially at the same time each day. Do not stop or change the dosage of Jitosita ME 100/500 Tablet without consulting your doctor, as this may prevent you from achieving the desired results. If you are unsure about the administration procedure of Jitosita ME 100/500 Tablet, ask your doctor or pharmacist for clarification.

• Missed Dose

If you miss a dose of Jitosita ME 100/500 Tablet, take it as soon as it is remembered. If it is time for your next dose of Jitosita ME 100/500 Tablet, omit the missed dose and resume your normal schedule. Never take double doses at the same time to make up for the missed one.

• Overdose

If there is any accidental overdose of Jitosita ME 100/500 Tablet then seek immediate medical advice or contact with the poison information centre in case of emergency, as it can cause serious side effects.

Contraindications of Jitosita ME 100/500 Tablet:

Do not take Jitosita ME 100/500 Tablet if you are hypersensitive or allergic to Sitagliptin, Metformin or any of the ingredients of this medicine. Jitosita ME 100/500 Tablet should also be avoided if you have insulin-dependent or type 1 diabetes mellitus, severe kidney or liver disease, heart problems or heart failure, severe infections or dehydration.

Avoid taking Jitosita ME 100/500 Tablet if the packaging is damaged or tampered with, or if it is past its expiry date.

Precautions & Warnings of Jitosita ME 100/500 Tablet:

Before starting Jitosita ME 100/500, inform your doctor if you have a history of metabolic acidosis including diabetic or lactic acidosis, pancreatitis, kidney or liver problems, heart disease, or if you are over 80 years old, as these conditions may increase the risk of side effects.

Side Effects of Jitosita ME 100/500 Tablet:

Jitosita ME 100/500 Tablet may have some possible side effects, although they are generally negligible and usually subside as your body adjusts to the medication. However, if these effects persist, you should consult your doctor. Common side effects of Jitosita ME 100/500 Tablet may include hypoglycaemia (low blood sugar), nausea, vomiting, diarrhea, constipation, rashes or blisters on skin and painful joints.

In some rare cases, more serious side effects such as severe allergic reactions, kidney problems, vitamin B12 deficiency, & hypoglycemia and its symptoms such as, headache, drowsiness, hunger, irregular heartbeat, may occur which require immediate medical attention.

Safety Related Advices Of Jitosita ME 100/500 Tablet:

• Pregnancy

If you are pregnant or planning to become pregnant, consult with your doctor while taking Jitosita ME 100/500 Tablet, is safe for you, as it may have an impact on your developing baby.

Generally, if you have gestational diabetes, your doctor may decide to treat you with Insulin instead of taking Jitosita ME 100/500 Tablet. Always follow your doctor's advice and inform them if you are pregnant or planning to conceive so that they can choose the safest treatment for you and your baby.

• Breastfeeding

Breastfeeding mothers are advised to avoid Jitosita ME 100/500 Tablet as it can pass through breast milk and may affect your breastfed baby. If you notice any unusual symptoms while taking Jitosita ME 100/500 Tablet or have any other concerns about your baby, it is important to talk to your doctor immediately.

• Alcohol

Drinking alcohol might interact with the effectiveness of Jitosita ME 100/500 Tablet and may increase the risk of a serious condition called lactic acidosis. Therefore, it is recommended to avoid excessive consumption of alcohol while taking Jitosita ME 100/500 Tablet.

• Food Interaction

Avoid excessive sugary foods and refined carbohydrates that cause rapid glucose spikes difficult to manage even with medication. Maintain balanced diets with whole grains, lean protein, healthy fats, and plenty of vegetables and fruits. Ask your doctor before drinking grapefruit juice, as it may interact with some medicines. Stay well-hydrated and avoid dehydration caused by heat, illness, or not drinking enough fluids, because it can increase the risk of lactic acidosis while taking Jitosita ME 100/500 Tablet.

• Drug Interaction

Jitosita ME 100/500 Tablet may interact with certain medicines, including:

Insulin or sulfonylureas – may increase the risk of low blood sugar.

Diuretics – may affect kidney function and blood glucose control.

Corticosteroids – may increase blood sugar levels.

Certain blood pressure medicines – may affect kidney function.

Contrast dyes used in certain X-ray/CT procedures – may require temporary discontinuation of Metformin.

Other medicines affecting kidney function – may increase the risk of Metformin accumulation.

Always inform your doctor about all prescription medicines, over-the-counter medicines, and supplements you are taking.

• Driving & Using Machinery

Jitosita ME 100/500 Tablet has no or negligible influence on your ability to drive or use machines. However, if you feel unwell, experience dizziness, blurred vision, drowsiness or symptoms of low blood sugar, which may affect your alertness, it is best to avoid driving or operating machinery. Also, if you take this tablet in combination with a sulphonylurea or insulin, the risk of hypoglycaemia increases, so extra caution is required.

Storage of Jitosita ME 100/500 Tablet:

Store below 30°C. Protected from moisture. Keep out of reach of children.

Avoid using it after the expiry date, printed on the packaging. Dispose of expired or unused medication properly; do not throw it away casually.

Helpful Tips:

• Take the tablet at the same time every day to help maintain consistent blood sugar control.
• Follow a balanced diabetic diet and regular exercise plan along with the medicine.
• Monitor your blood glucose levels regularly as advised by your healthcare professional.
• Stay adequately hydrated, particularly during hot weather, vomiting, or diarrhoea.
• Regularly monitor kidney function as advised, particularly during long-term treatment.
• Keep a quick source of sugar, such as glucose tablets, sugar, fruit juice, or regular non-diet soft drink, readily available for emergency use in case of symptoms of low blood sugar or hypoglycemia.
• Do not share your medicine with someone else having the same symptoms as you.

Related Blood Glucose Monitors:

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Frequently Asked Questions (FAQs):

Q. Why did my doctor prescribe me Jitosita ME 100/500 Tablet?

A. Jitosita ME 100/500 Tablet is prescribed for the treatment of Type 2 Diabetes or non-insulin-dependent diabetes mellitus (NIDDM).

By maintaining the blood sugar, it may also prevent other complications of diabetes such as stroke, heart attack, kidney failure, nerve damage, eye problems, and delay wound healing.

Q. When is the best time to take Jitosita ME 100/500 Tablet and why?

A. Jitosita ME 100/500 Tablet should be taken as advised by your doctor, preferably at the same time each day. However, it is recommended to take it along with meals because after meals, there is a spike in blood glucose levels, and the body requires support to help lower the glucose level. This may also decrease the chance of stomach discomfort.

Q. How long should we take Jitosita ME 100/500 Tablet?

A. Jitosita ME 100/500 Tablet should be taken as long as your doctor has prescribed it. You should not stop taking Jitosita ME 100/500 Tablet during your treatment without consulting your doctor, as it could affect the effectiveness of your therapy. Type 2 diabetes is a long term condition, and this medicine helps manage your blood sugar levels over time. Interrupting treatment suddenly can cause your blood sugar to rise again, increasing the risk of complications like nerve damage, kidney problems, or heart disease. If you are experiencing side effects or feel your condition has improved, talk to your doctor. They may adjust your dose or explore other treatment options, but stopping on your own can be risky.

Q. Does Jitosita ME 100/500 Tablet cause low blood sugar or hypoglyceamia?

A. Jitosita ME 100/500 Tablet is an anti-diabetic medicine, used for the treatment of Type 2 diabetes mellitus and on its own, it does not cause hypoglycemia. However, if you take any other anti-diabetic medicines, such as sulfonylurea or insulin, then it might cause hypoglycaemia. Consult with your doctor immediately if you notice any of the symptoms like sweating, headache, hunger, shakiness, rapid heartbeat, dizziness or confusion, etc.

Q. Are Janumet 50/500 and Jitosita ME the same medicine?

A: Janumet 50/500 and Jitosita ME are both anti diabetic medications used to treat type 2 diabetes and contain the same active ingredients, Sitagliptin and Metformin. And, they work similarly by helping to control blood sugar levels. The main difference between these two medicines is, they are manufactured by different companies. It is important not to switch between Janumet and Jitosita ME without consulting your doctor, as the most appropriate medication for you depends on your overall health, existing medical conditions, how your body responds to the treatment, and how well you tolerate it. Always follow your doctor’s guidance when it comes to starting, stopping, or changing your diabetes medication.

References:

1. Sitagliptin/Metformin 50 mg/1000 mg film-coated tablets. Last Revised: March 2025. Accessed on: 27th August 2026. Click Here

2. Sitagliptin/Metformin hydrochloride Mylan 50 mg/850 mg film-coated tablets. Sitagliptin/Metformin hydrochloride Mylan 50 mg/1,000 mg film-coated tablets.  Accessed on: 27th August 2026. Click Here

3. JANUMET XR (sitagliptin and metformin HCl extended-release) tablets. Prescribing Information. Last Revised: February 2013. Accessed on: 27th August 2026. Click Here

4. SANDOZ SITAGLIPTIN-METFORMIN Sitagliptin and metformin hydrochloride tablets. Last Revised: 27th July, 2023. Accessed on: 27th August 2026. Click Here