Jitoranoz 500 Tablet (10 Tab)

Jitoranoz 500 Tablet Overview:

Jitoranoz 500 Tablet is an anti-anginal medicine used to manage chronic stable angina- a long-term chest pain or discomfort caused by reduced blood flow to the heart, often triggered by physical activity.

The pain may be felt from the neck to the upper abdomen. Jitoranoz 500 contains ranolazine, which helps the heart muscle relax by balancing sodium levels in heart cells, improving blood flow without affecting heart rate or blood pressure.

Jitoranoz 500 Tablet is usually prescribed as a “second-line” treatment when “first-line therapies” like beta-blockers or calcium channel blockers are insufficient to control the symptoms or cannot be tolerated by the patient. Jitoranoz 500 helps reduce the frequency of angina attacks and improves daily activity.

Composition:

Each film coated extended release tablet contains- Ranolazine: 500 mg.

Colours: Sunset Yellow FCF & Titanium Dioxide.

Uses & Benefits of Jitoranoz 500 Tablet:

Jitoranoz 500 Tablet is used for the following:

• Management of chronic stable angina (long-term chest pain due to reduced blood flow to the heart)
• Reduction in the frequency of angina (chest pain) attacks

How Does Jitoranoz 500 Tablet Work:

Ranolazine is the main ingredient of Jitoranoz 500 Tablet, which selectively inhibits the late sodium current (INa) in the heart. When the heart doesn't get enough oxygen (a condition called ischemia), there is an excess buildup of sodium inside the cells. This causes an overload of sodium, which then leads to a buildup of calcium. Too much calcium makes the heart muscle stiff and "cramped," preventing it from relaxing properly between beats. By blocking late sodium entry, Ranolazine reduces calcium overload, allowing the heart to relax, improving oxygen supply, and reducing the pressure and pain associated with chronic angina.

Dosage of Jitoranoz 500 Tablet:

• Usage Direction

Take Jitoranoz 500 Tablet strictly according to your doctor’s instructions, following the prescribed dose and timing. Jitoranoz 500 Tablet should be swallowed whole with a glass of water without crushing, chewing, or breaking it, preferably at the same time each day. Do not stop or alter the dose of Jitoranoz 500 Tablet without consulting your doctor, as this may prevent you from achieving the desired outcome. If you are unsure about the administration procedures of Jitoranoz 500, consult with your doctor or pharmacist.

• Missed Dose

If you miss a dose of Jitoranoz 500 Tablet, take it as soon as you remember on the same day. But, if it is almost time for your next scheduled dose, skip the one you missed and continue following your regular dosing schedule. Do not attempt to take two doses if you have forgotten one. If you often forget to take your medication, consult with your doctor to re-evaluate your dosing schedule. Frequently missing doses could lead to undesired outcomes.

You can set reminders on your smartphone, keep drug organizer boxes, or use other audio-visual technologies to prevent missing a dose.

• Overdose

If you accidentally take Jitoranoz 500 Tablet more than your prescribed dose, seek immediate medical advice or visit an emergency room immediately. Symptoms of overdose may include vomiting, nausea, or dizziness.

Contraindications of Jitoranoz 500 Tablet:

Do not take Jitoranoz 500 Tablet if you are hypersensitive or allergic to Ranolazine or any of the components of this medicine. This medication is also not recommended for patients with moderate to severe liver disease (cirrhosis) or serious kidney problems, as these conditions can affect how your body clears the medicine.

Precautions & Warnings of Jitoranoz 500 Tablet:

Before starting Jitoranoz 500 Tablet, it is essential to inform your doctor if you have a history of heart rhythm issues (such as "QT prolongation"). Because Ranolazine affects the heart’s electrical signals, your physician may need to monitor your heart's rhythm more closely.

Talk to your doctor before taking this medicine if you have mild or moderate kidney and liver disease, heart failure, or ever had an abnormal electrocardiogram (ECG). Moreover, precautions for elderly patients and those with lower body weight (60 kg or less) must be carefully observed by their healthcare provider.

Side Effects of Jitoranoz 500 Tablet:

Jitoranoz 500 Tablet may cause some side effects, most of which are mild to moderate and usually disappear as your body adjusts to the medication. Common symptoms may include dizziness, headache, vomiting, nausea and constipation.

In some cases, more serious side effects may occur and require immediate medical attention, such as fast/pounding heartbeat (palpitations), affected heart's electrical rhythm (QT prolongation) or, in rare cases, impact kidney function (acute renal failure). Consult your physician immediately if you experience severe lightheadedness, a spinning sensation (vertigo), blurred vision, or a sudden drop in blood pressure when standing up (orthostatic hypotension).

Safety Related Concerns of Jitoranoz 500 Tablet:

• Pregnancy

If you are pregnant or planning to become pregnant, consult your doctor before taking Jitoranoz 500 Tablet. It is usually avoided during pregnancy due to the lack of sufficient studies and the possible risk of harm to the developing fetus. Use only if the potential benefit outweighs the risk to the fetus.

• Breastfeeding

It is better to avoid the use of the Jitoranoz 500 Tablet while breastfeeding, since it is unknown whether the active ingredients of this medicine could pass into the breast milk and affect the breastfed child. Therefore, consulting with your doctor before taking Jitoranoz 500 is crucial.

• Alcohol

Avoid drinking alcohol while taking Jitoranoz 500 Tablet, as it may significantly increases the side effects, such as lightheadedness, fainting, drowsiness, or dizziness. Please consult with your doctor.

• Food Interactions

Jitoranoz 500 Tablet can be taken with or without food, as prescribed by your physician. However, avoid grapefruit and grapefruit juices, as they increase the levels of the medicine in the blood to potentially toxic levels. However, it is vital to maintain a heart-healthy diet with balanced dietary habits, avoid fatty foods, particularly saturated fats. These types of fats can contribute to blockages in the heart’s arteries, which is a leading cause of angina pain. By choosing leaner proteins and plenty of vegetables, you can help the medicine work more effectively in protecting your heart.

• Drug Interactions

Jitoranoz 500 Tablet should not be taken with certain medicines as they can significantly alter its effect in the body. These include strong antibiotics (such as clarithromycin), antifungal drugs (like ketoconazole), and some antiviral medicines (such as ritonavir), which may increase the risk of side effects. Herbal products like St. John’s Wort and certain anti-seizure medicines (e.g., phenobarbital) should also be avoided, as they can reduce its effectiveness.

It may also interact with some heart or blood pressure medicines like diltiazem or verapamil, which can raise ranolazine levels in the body. Additionally, Jitoranoz 500 can increase the levels of other drugs such as digoxin and simvastatin, potentially leading to toxicity. Therefore, dose adjustments and medical supervision are important when these medicines are used together.

Always inform your healthcare provider and pharmacist about all medications you are taking, including prescription drugs, over-the-counter medications, vitamins, minerals, and herbal supplements, to avoid potential interactions.

• Using Machinery & Driving

Jitoranoz 500 Tablet may cause dizziness, vertigo, drowsiness, lightheadedness, or visual disturbances in some people. Patients should use caution and avoid driving or operating machinery until they are sure the medication does not affect their alertness.

Storage of Jitoranoz 500 Tablet:

Store protected from light & moisture, at a temperature not exceeding 30°C. Keep out of reach of children. Avoid using it after the expiry date, printed on the packaging. Dispose of expired or unused medication properly; do not throw it away casually.

Additional Information:

• To manage chronic angina effectively adopt a heart-healthy diet low in saturated fats and sodium.
• Engage in physician-approved light exercise, relaxation techniques like deep breathing or yoga to improve cardiovascular health.
• Quitting smoking is vital for reducing the workload on the heart.
• High stress can trigger chest pain, so practicing relaxation techniques like deep breathing, meditation, or yoga can help keep your symptoms under control.
• Do not suddenly stop your medication unless your doctor specifically tells you to.
• Do not share your medicine with someone else having the same symptoms as you, as the drug requires a prescription.

Frequently Asked Questions (FAQs):

Q. Why Jitoranoz 500 Tablet is prescribed?

A. Jitoranoz 500 Tablet is prescribed for the treatment of chronic stable angina (chest pain).

Q. Can Jitoranoz 500 Rablet stop a sudden angina attack?

A. No, Jitoranoz 500 is for long-term management. For sudden, acute chest pain, you should first consult with the physician. The doctor may suggest some alternatives or a fast-acting nitrate (like a nitroglycerin spray or tablet) to treat your condition.

Q. Does Jitoranoz 500 Tablet helps to lower blood pressure?

A. No, Jitoranoz 500 Tablet has minimal effects on heart rate and blood pressure compared to other other angina medications. So, if you have high blood pressure (hypertention) inform your doctor before taking the medication.

Q. Can I crush the tablet if I have trouble swallowing?

A. No, you should not crush, break, or chew Jitoranoz 500 Tablet. It is designed to release the medicine slowly over time. Crushing or chewing it can cause the drug to be released too quickly, increasing the risk of side effects and reducing its effectiveness.

If you have difficulty swallowing, consult your doctor—they may suggest an alternative formulation or a more suitable option.

Q. Who should avoid taking Jitoranoz 500?

A. Jitoranoz 500 Tablet should be strictly avoided by patients with severe kidney or liver disease (cirrhosis), as these conditions prevent the body from safely processing and clearing the medication.

Q. Why Jitoranoz 500 Tablet should not be taken with certain medication?

A. It is important to avoid taking Jitoranoz 500 at the same time as certain other medicines, especially those used to treat irregular heart rhythms or any drugs that work in a similar way to Ranolazine. Combining these can increase the risk of serious side effects, such as dangerous changes to your heart's electrical signals. Always provide your doctor with a complete list of your current medications to ensure Jitoranoz 500 is a safe choice for you.

Reference:

1. Ranexa 375 mg prolonged-release tablets. Accessed on: 27th March 2026. Click Here

2. FULL PRESCRIBING INFORMATION. RANEXA. Last Revised: January 2016. Accessed on: 27th March 2026. Click Here

3. Package leaflet: Information for the patient. Ranolazine 375 mg / 500 mg / 750 mg Prolonged-release tablet. Last Revised: December 2023. Accessed on: 27th March 2026. Click Here

4. Package leaflet: Information for the patient. Anzipro 375 mg / 500 mg / 750 mg Prolonged-release tablet. Last Revised: May 2023. Accessed on: 27th March 2026. Click Here