Jitopreg NTMC 75/10/1500 Tablet (10 Tab)

Jitopreg NTMC 75/10/1500 Tablet Overview:

Jitopreg NTMC 75/10/1500 Tablet is a prescription medicine used for the management of neuropathic pain associated with conditions such as diabetic peripheral neuropathy, post-herpetic neuralgia, peripheral neuropathy, and other nerve disorders, particularly when vitamin B12 deficiency is present.

Neuropathic pain occurs when the nerves become damaged or do not function properly, causing symptoms such as burning, tingling, numbness, electric shock-like sensations, or increased sensitivity to touch. Coexisting vitamin B12 deficiency can further impair nerve function, worsen these symptoms, and delay nerve recovery.

Jitopreg NTMC 75/10/1500 Tablet contains Pregabalin, Methylcobalamin, and Nortriptyline. Pregabalin helps calm overactive nerves and reduces the transmission of pain signals. Nortriptyline modifies the way pain signals are processed in the central nervous system, helping to relieve chronic nerve pain. Methylcobalamin, the active form of vitamin B12, supports the repair and regeneration of damaged nerve tissue while restoring healthy nerve function. Together, these ingredients help relieve pain, promote nerve healing, and improve overall nerve health.

Composition:

Each film coated tablet contains- Pregabalin: 75 mg, Nortriptyline Hydrochloride equivalent to Nortriptyline: 10 mg, Methylcobalamin: 1500 mcg, and Excipients: q.s.

Colours: Sunset Yellow Lake & Titanium Dioxide

Appropriate overages of Methylcobalamin added to compensate for loss on storage.

Uses & Benefits of Jitopreg NTMC 75/10/1500 Tablet:

Jitopreg NTMC 75/10/1500 Tablet is used to relieve chronic nerve pain (neuropathic pain), promote nerve repair, and manage the following conditions:

• Diabetic Peripheral Neuropathy: Relieves burning, prickling, numbness, and sharp, stabbing sensations in the hands and feet caused by long-term high blood sugar levels damaging peripheral nerves.
• Post-Herpetic Neuralgia: Eases persistent, severe burning or shooting nerve pain that lingers in skin areas affected by a past shingles (varicella-zoster) infection.

• Spinal Cord Injury & Post-Traumatic Neuropathy: Relieves neuropathic pain resulting from spinal cord injuries, nerve compression, sciatica, or other traumatic nerve damage.

• Fibromyalgia & Chronic Musculoskeletal Pain: Helps manage widespread muscle pain, joint tenderness, fatigue, and associated sleep disturbances by modulating central pain perception.

• Drug-Induced Peripheral Neuropathy: Protects and helps regenerate nerve fibers damaged as a side effect of certain long-term medications (such as specific chemotherapy drugs or antivirals).

How Does Jitopreg NTMC 75/10/1500 Tablet Work:

Jitopreg NTMC 75/10/1500 Tablet combines three active ingredients—Pregabalin, Nortriptyline, and Methylcobalamin—to deliver a comprehensive, multi-target approach for managing nerve pain and restoring nerve health.

Pregabalin is an anticonvulsant that modulates voltage-gated calcium channels in nerve cells. This action reduces the excessive release of chemical signals that transfer pain to the brain.

Nortriptyline is a tricyclic antidepressant (TCA) that blocks the reuptake of serotonin and noradrenaline. By increasing the levels of these neurotransmitters in the central nervous system, it enhances the body's natural pain-inhibiting pathways.

On the other hand, Methylcobalamin is an active form of Vitamin B12 that plays a crucial role in synthesizing myelin—the protective sheath that insulates nerve fibers. This component actively supports the repair, regeneration, and nourishment of damaged nerve cells.

Together, Pregabalin and Nortriptyline block pain signals through complementary pathways, while Methylcobalamin works to repair the underlying structural nerve damage.

Dosage of Jitopreg NTMC 75/10/1500 Tablet:

• Usage Direction

Take Jitopreg NTMC 75/10/1500 Tablet exactly as advised by your doctor’s, following the prescribed dose and timing. Jitopreg NTMC 75/10/1500 Tablet should be swallowed whole with water without breaking, chewing, or crushing it, preferably at the same time each day. Do not stop or alter the dose of Jitopreg NTMC 75/10/1500 Tablet without consulting your doctor, as this may prevent you from achieving the desired outcome. If you are unsure about the administration procedures of Jitopreg NTMC 75/10/1500, consult with your doctor or pharmacist.

• Missed Dose

If you miss a dose of Jitopreg NTMC 75/10/1500 Tablet, take it as soon as you remember on the same day. But, if it is almost time for your next scheduled dose, skip the one you missed and continue following your regular dosing schedule. Do not take double doses if you have forgotten one.

If you often forget to take your medication, you can set reminders on your smartphone, keep drug organizer boxes, or use other audio-visual technologies to prevent missing a dose.

• Overdose

If you accidentally take Jitopreg NTMC 75/10/1500 Tablet more than your prescribed dose, seek immediate medical advice, as this may lead to serious side effects. An overdose can lead to severe drowsiness, rapid heartbeat, confusion, dizziness, or blurred vision.

Contraindications of Jitopreg NTMC 75/10/1500 Tablet:

Do not take Jitopreg NTMC 75/10/1500 Tablet if you have a known allergy or hypersensitivity to Pregabalin, Methylcobalamin, Nortriptyline, any TCAs, or any other ingredients present in this medicine.

The medicine is not recommended for patients with a recent history of heart attack (myocardial infarction) or severe arrhythmia.

Precautions & Warnings of Jitopreg NTMC 75/10/1500 Tablet:

Before starting Jitopreg NTMC 75/10/1500 Tablet, it is essential to consult your healthcare provider and thoroughly discuss your complete medical history. Special caution and dosage monitoring are required for individuals with pre-existing heart disease, kidney impairment, liver conditions, severe urinary retention, or uncontrolled angle-closure glaucoma. Regular monitoring of Vitamin B12 levels is also recommended during treatment.

Patients must be closely observed for sudden mood shifts, worsening depression, or suicidal thoughts, especially during early treatment or dose adjustments. Discontinuing the medicine suddenly can cause withdrawal symptoms like anxiety, insomnia, sweating, or returning pain. Any reduction in dosage must be gradually tapered under medical supervision.

Lastly, inform your surgeon or anesthesiologist if you are taking this medicine, as it may need to be temporarily paused before elective surgery to avoid blood pressure complications during anesthesia.

Side Effects of Jitopreg NTMC 75/10/1500 Tablet:

Jitopreg NTMC 75/10/1500 Tablet side effects are typically mild to moderate and resolve as your body adjusts. Common side effects may include drowsiness, fatigue, or sleepiness, dizziness, dry mouth, constipation, weight gain or increased appetite, and blurred vision.

Conversely, rare serious side effects may also occur, requiring immediate medical advice. Symptoms can range from palpitations and suicidal thoughts to peripheral edema, abdominal cramps, liver function alterations, and a severe allergic reaction that results in swelling of the face, lips, or tongue.

Safety Related Concerns of Jitopreg NTMC 75/10/1500 Tablet:

• Pregnancy

Jitopreg NTMC 75/10/1500 Tablet is not recommended during pregnancy, unless prescribed by your doctor, as limited data exist regarding its safety in pregnant women. If you are pregnant or planning to become pregnant, talk to your doctor before taking this medication to weigh the benefits against potential risks to the developing baby.

• Breastfeeding

It is recommended to avoid using Jitopreg NTMC 75/10/1500 Tablet while breastfeeding. The components may pass into breast milk and pose risks to the nursing infant. So always consult with your doctor before taking the medicine.

• Alcohol

Avoid consuming alcohol while taking Jitopreg NTMC 75/10/1500 Tablet, as it increases central nervous system depression, leading to severe drowsiness, dizziness, and motor impairment.

• Food Interactions

There are no significant food interactions associated with Jitopreg NTMC 75/10/1500 Tablet. It can be taken with or without meals as suggested.

To ensure safety, patients with known food allergies or dietary restrictions should consult their healthcare professional before starting the medication.

• Drug Interactions

Jitopreg NTMC 75/10/1500 Tablet can interact with a wide variety of medications, which can either compromise their effectiveness or increase the risk of toxicity. Concomitant use with Monoamine Oxidase Inhibitors (MAOIs), SSRIs, or SNRIs is dangerous and can trigger severe, life-threatening conditions like serotonin syndrome or hypertensive crises.

Additionally, combining this medication with central nervous system depressants, such as sedatives, sleeping pills, opioid analgesics, or anti-anxiety drugs, increases the risk of severe drowsiness, respiratory depression, and impaired motor function.

Other antiepileptic agents may alter drug plasma levels and seizure control thresholds. At the same time, the use of oral contraceptives may decrease the therapeutic concentration of active components, potentially reducing the medication's overall efficacy.

Always inform your healthcare provider of all prescription medications, over-the-counter drugs, and herbal supplements you are taking before starting treatment.

• Using Machinery & Driving

Jitopreg NTMC 75/10/1500 Tablet can cause alertness-impairing symptoms such as dizziness, drowsiness, and blurred vision. Do not drive or handle heavy machinery until you know how the medicine affects you.

Storage of Jitopreg NTMC 75/10/1500 Tablet:

Store at a temperature not exceeding 30°C. Protected from light and moisture. Keep the medicine out of reach of children.

Avoid using it once the expiry date on the packaging has been reached. Properly dispose of any expired or unused medications; do not throw it away casually.

Additional Information:

• For diabetic patients, keeping blood glucose within target ranges is essential to prevent further nerve deterioration.
• Inspect feet daily for unnoticed cuts, sores, or blisters, as nerve damage reduces sensation.
• Eat a balanced, high-fiber diet and engage in light exercise (like walking) to offset potential weight gain caused by Pregabalin.
• Stay well-hydrated, take frequent sips of water, chew sugar-free gum, or maintain good oral hygiene to keep the mouth moist.
• Avoid stopping your medication suddenly unless instructed by your physician.
• Do not give your medicine to someone else who has the same symptoms, as it is a prescription medication.

Frequently Asked Questions (FAQs):

Q: Why is Jitopreg NTMC 75/10/1500 Tablet prescribed?

A: Jitopreg NTMC 75/10/1500 Tablet is primarily prescribed to treat and manage chronic neuropathic pain (nerve pain). It helps relieve burning, tingling, and stabbing sensations caused by nerve damage from conditions like diabetic peripheral neuropathy, post-herpetic neuralgia (after shingles), and spinal cord injuries, while also aiding in damaged nerve repair.

Q: Can I stop taking Jitopreg NTMC 75/10/1500 Tablet once my nerve pain goes away?

A: No, you should not stop taking the tablet abruptly, even if your pain improves. Stopping suddenly can trigger withdrawal symptoms—such as anxiety, insomnia, sweating, and nausea—or cause your nerve pain to return. When it is time to discontinue the medication, your doctor will guide you on how to gradually taper down your dosage safely.

Q: Why is it advised to take Jitopreg NTMC 75/10/1500 Tablet at night?

A: Healthcare providers often recommend taking Jitopreg NTMC 75/10/1500 Tablet at bedtime because two of its active components—Pregabalin and Nortriptyline—commonly cause central nervous system effects such as drowsiness, sedation, and dizziness. Aligning the dose with your sleep schedule allows these sedative effects to assist with nighttime rest while minimizing daytime sleepiness and cognitive impairment. However, timing and dosage should always be tailored to your specific daily routine and health profile as advised by your prescribing physician.

Q: Will Jitopreg NTMC 75/10/1500 Tablet cause weight gain?

A: Weight gain is a known potential side effect associated with both Pregabalin and Nortriptyline, primarily due to increased appetite or fluid retention. Maintaining a balanced diet and regular physical activity, as recommended by your healthcare provider, can help manage body weight during treatment.

Q: Is Jitopreg NTMC 75/10/1500 Tablet habit-forming or addictive?

A: While Jitopreg NTMC 75/10/1500 Tablet is not considered traditional narcotics or typical addictive substances, Pregabalin carries a potential risk of psychological dependence or misuse, particularly in individuals with a personal or medical history of substance abuse. This is why it is prescribed strictly under medical supervision and should never be taken in higher doses or for longer durations than recommended.

Q: Is Jitopreg NTMC 75/10/1500 Tablet safe for elderly patients?

A: Elderly patients may be more sensitive to the central nervous system side effects of Pregabalin and Nortriptyline, such as severe dizziness, confusion, dry mouth, or loss of balance, which can increase the risk of accidental falls. Physicians typically prescribe lower starting doses and closely monitor elderly individuals during initial therapy.

References:

1. PREGABA-MNT. Pregabalin (Prolonged Release), Methylcobalamin and Nortriptyline Hydrochloride Tablets. Last Revised: May 2022. Accessed on: 4th August 2026. Click Here

2. PREGABANYL-NTM. Pregabalin, Methylcobalamin and Nortriptyline. Accessed on: 4th August 2026. Click Here

3. Subneuro-NT. Methylcobalamin 1500mcg + Pregabalin 75mg + Nortriptyline 10mg Uncoated Tablets. For consumer information only. Accessed on: 4th August 2026. Click Here