Jitoorni OF 500/200 Tablet (10 Tab)

Jitoorni OF 500/200 Tablet Overview

Jitoorni OF 500/200 Tablet is an antibiotic medication primarily used to treat broad-spectrum gastrointestinal tract infections and mixed infections, specifically acute infectious diarrhea in adults.

It combines two potent antimicrobial agents—Ofloxacin and Ornidazole, which work directly by destroying infection-causing bacteria and inhibiting the growth of harmful microorganisms. This dual-action synergy provides robust coverage against both Gram-positive and Gram-negative bacterial pathogens as well as anaerobic protozoal parasites.

Composition:

Each film coated tablet contains- Ofloxacin: 200 mg, Ornidazole: 500 mg, and Excipients q.s.

Colour: Sunset Yellow FCF & Titanium Dioxide.

Uses & Benefits of Jitoorni OF 500/200 Tablet:

Jitoorni OF 500/200 Tablet is used for the treatment of diarrhoea of mixed infection in adult patients.

How Does Jitoorni OF 500/200 Tablet Work:

Jitoorni OF 500/200 Tablet contains two active ingredients- Ofloxacin, from the fluoroquinolone class of antibiotics, and Ornidazole, from the nitroimidazole class of antimicrobials. They use distinct, complementary mechanisms to treat diarrhoeal infections.

Ofloxacin works by inhibiting DNA gyrase (specifically topoisomerase II and IV), a bacterial enzyme required for DNA replication, transcription, repair, and recombination. Blocking this enzyme halts cell division and destroys the bacteria.

Ornidazole enters the microbial cell via passive diffusion, where its nitro group is chemically reduced by anaerobic micro-organisms into reactive cytotoxic intermediates. These intermediates damage microbial DNA and block protein synthesis, leading to cell death in the anaerobic bacteria and protozoal parasites responsible for dysentery and amoebiasis.

Together, these mechanisms provide a powerful, dual-action approach that rapidly clears diarrhoea-causing mixed infections.

Dosage of Jitoorni OF 500/200 Tablet:

• Usage Direction

Take Jitoorni OF 500/200 Tablet strictly as advised by your doctor, following the prescribed dose and timing. Jitoorni OF Tablet should be swallowed whole with water without crushing, chewing, or breaking it, preferably at the same time each day. Do not stop or alter the dose of Jitoorni OF 500/200 Tablet without consulting your doctor, as this may prevent you from achieving the desired outcome. To know further about the administration procedures of Jitoorni OF Tablet, consult with your doctor or pharmacist.

• Missed Dose

If you miss a dose of Jitoorni OF 500/200 Tablet, take it as soon as you remember on the same day. But, if it is almost time for your next scheduled dose, skip the one you missed and continue following your regular dosing schedule. Do not attempt to take two doses if you have forgotten one. If you often forget to take your medication, consult with your doctor to re-evaluate your dosing schedule. Frequently missing doses could lead to undesired outcomes.

You can set reminders on your smartphone, keep drug organizer boxes, or use other audio-visual technologies to prevent missing a dose.

• Overdose

Taking more than the recommended dose of Jitoorni OF Tablet can increase the severity of side effects, leading to severe dizziness, confusion, loss of consciousness, convulsive seizures, or gastrointestinal distress. In case of accidental overdose, seek immediate medical care, contact your doctor, or go to your nearest hospital.

Contraindications of Jitoorni OF 500/200 Tablet:

Do not take Jitoorni OF 500/200 Tablet if you have a known hypersensitivity or allergy to Ofloxacin and Ornidazole, as well as any other fluoroquinolone or nitroimidazole derivatives.

Due to serious risks to the central nervous system and musculoskeletal structure, it must not be used by patients with a history of tendonitis, myasthenia gravis (as it can severely exacerbate muscle weakness), epilepsy, or other CNS disorders that lower the seizure threshold.

Furthermore, the medication is unsafe for individuals suffering from active renal or hepatic disorders, or those with a glucose-6-phosphate dehydrogenase (G6PD) deficiency, which significantly increases the risk of dangerous haemolytic reactions.

Additionally, Jitoorni OF 500/200 Tablet is strictly prohibited in pediatric patients, growing adolescents, and women who are pregnant or breastfeeding, because the drug poses a specific risk of damaging the developing cartilage of joints in growing subjects.

Precautions & Warnings of Jitoorni OF 500/200 Tablet:

Before starting Jitoorni OF 500/200 Tablet, it is essential to consult your healthcare provider and thoroughly discuss your complete medical history. The initial dose comes with the risk of severe allergic responses, including life-threatening anaphylactic reactions, allergic pneumonitis, and critical skin conditions like Stevens-Johnson syndrome or toxic epidermal necrolysis.

Additionally, the Ofloxacin component is associated with an increased risk of tendonitis and tendon rupture, requiring immediate discontinuation and medical consultation if any joint or tendon pain occurs.

Patients should also be aware that the medication can induce low blood sugar (hypoglycemia) and mental health-related side effects, making close blood glucose monitoring vital for individuals with diabetes.

Finally, you must stop taking the tablet and promptly inform your physician if you experience numbness, tingling, or burning sensations in your hands or feet, as these are warning signs of developing peripheral neuropathy.

Side Effects of Jitoorni OF 500/200 Tablet:

While taking the Jitoorni OF 500/200 Tablet, you might experience some side effects; however, most of them are mild and temporary as your body gets used to the medication. The most common symptoms include nausea, vomiting, abdominal pain or stomach cramps, dizziness or lightheadedness, headache, skin itching or mild rashes, vertigo, and confusion.

Serious side effects may be uncommon, but they require immediate medical intervention if they occur. You should contact your doctor right away if you experience hypotension, tachycardia, jaundice, acute renal failure, convulsions or seizures, haemolytic reactions, etc.

Label Information: This drug may cause low blood sugar and mental health related side effects.

Safety Related Concerns of Jitoorni OF 500/200 Tablet:

• Pregnancy

Jitoorni OF 500/200 Tablet is generally not recommended during pregnancy unless prescribed by a healthcare professional. If you are pregnant or you are planning to get pregnant, consult your physician before taking the medicine, who has determined that the benefits clearly outweigh the potential risks.

• Breastfeeding

The active ingredients of Jitoorni OF 500/200 Tablet may pass into breast milk. Consult your doctor beforehand to determine whether to stop nursing temporarily or suggest alternative treatments.

• Alcohol

It is advised to avoid alcohol consumption completely while taking Jitoorni OF 500/200 Tablet. Combining alcohol with nitroimidazoles (like Ornidazole) can potentially trigger adverse reaction, leading to intense nausea, abdominal cramps, dizziness flushing, and a rapid heartbeat.

• Food Interactions

Jitoorni OF 500/200 Tablet can be taken with or without food as advised by your doctor. However, avoid taking this medicine concurrently with dairy products (milk, cheese, yogurt), as these can significantly reduce its systemic absorption. Consume these items at least 2 hours before or after your dose.

• Drug Interactions

Jitoorni OF 500/200 Tablet may interact with several medications, potentially affecting its efficacy or increasing the risk of adverse effects.

Antacids containing magnesium or aluminum, sucralfate, iron, zinc preparations, and didanosine may significantly reduce ofloxacin absorption. Administer Jitoorni OF 500/200 Tablet at least 2 hours before or after these products.

Concomitant use with theophylline, fenbufen, NSAIDs, or other agents that lower the seizure threshold may increase the risk of convulsions.

Probenecid, cimetidine, furosemide, and methotrexate may alter renal excretion of ofloxacin, potentially increasing systemic exposure.

Use caution with medications known to prolong the QT interval, including certain antiarrhythmics, antidepressants, macrolides, and antipsychotics.

Warfarin and other vitamin K antagonists may have enhanced anticoagulant effects; regular PT/INR monitoring is recommended.

Concurrent use with glibenclamide may increase the risk of hypoglycaemia; regular blood glucose monitoring is advised.

Fluoroquinolones, including ofloxacin, should be avoided in patients with a history of tendon disorders, as they may increase the risk of tendinitis, tendon rupture, peripheral neuropathy, and central nervous system (CNS) effect

Always inform your healthcare provider and pharmacist about all medications you are taking, including prescription drugs, over-the-counter medications, vitamins, minerals, and herbal supplements, to avoid potential interactions.

Using Machinery & Driving

Jitoorni OF 500/200 Tablet may cause dizziness, drowsiness, or vertigo in some patients. If you experience these symptoms, do not drive, operate heavy machinery, or participate in tasks requiring complete mental alertness until you know how the medication affects you.

Storage of Jitoorni OF 500/200 Tablet:

Store below 25°C. Protect from light & moisture. Keep out of the reach of children.

Avoid using it after the expiry date, printed on the packaging. Dispose of expired or unused medication properly; do not throw it away casually.

Additional Information:

• When managing diarrhea or dysentery, take Oral Rehydration Salts (ORS), coconut water, or clear broths to replenish lost fluids and prevent dehydration.
• Focus on consuming easily digestible foods in smaller amounts (such as rice, bananas, or applesauce).
• Avoid highly spicy, oily, or high-fat foods until your gastrointestinal system recovers.
• Consider discussing the inclusion of a probiotic supplement or natural yogurt with your doctor after completing the antibiotic course to restore healthy gut flora.
• Do not suddenly stop your medication unless your doctor specifically tells you to.
• Do not share your medicine with someone else having the same symptoms as you.

Frequently Asked Questions (FAQs):

Q. Why is Jitoorni OF 500/200 Tablet advised?

A. Jitoorni OF 500/200 Tablet is prescribed for the treatment of diarrhoea of mixed infection in adult patients.

Q. How does this medication work?

A. Jitoorni OF Tablet combines two active ingredients- Ofloxacin (a fluoroquinolone antibiotic) and Ornidazole (an antiprotozoal agent). Together, they target and kill harmful parasites and anaerobic bacteria, stopping their growth to clear the infection.

Q. Can I stop taking Jitoorni OF 500/200 Tablet once my diarrhea stops?

A. No. You must complete the exact course prescribed by your doctor. Stopping antibiotics early allows the remaining bacteria to survive, which can cause the infection to return and increases the risk of the microbes becoming drug-resistant.

Q. Why is it advised to avoid milk with Jitoorni OF 500/200 Tablet?

A. Milk and other calcium-rich products chemically bind to Ofloxacin (one of the active components) in the stomach. This binding prevents the medication from being properly absorbed into your bloodstream, making the overall treatment much less effective.

Q. Does Jitoorni OF 500/200 Tablet treat viral flu or common cold?

A. No. Jitoorni OF 500/200 Tablet consists of antibacterial and antiprotozoal drugs. It is entirely ineffective against viral infections like the cold or flu.

References:

1. OFLOX-OZ Tablets. Ofloxacin + Ornidazole. Prescribing Information. Last Revised: 26 November 2020. Accessed on: 19th June 2026. Click Here

2. OF-2. Ofloxacin and Ornidazole Tablets. Last Revised: August 2022. Accessed on: 19th June 2026. Click Here