Jitolosa HZ 50/12.5 Tablet (10 Tab)

Jitolosa HZ 50/12.5 Tablet Overview:

Jitolosa HZ 50/12.5 Tablet is a combination anti-hypertensive medication primarily used to treat high blood pressure (hypertension).

It contains two active ingredient- Losartan Potassium, an Angiotensin II Receptor Antagonist, and Hydrochlorothiazide, a diuretic (water pill), which work together to lower blood pressure more effectively than a single medication alone. Together, they help relax or widen blood vessels to improve blood flow and help the body eliminate excess salt and water.

By controlling blood pressure, Jitolosa HZ 50/12.5 also helps reduce the risk of serious cardiovascular events, such as stroke and heart attack (myocardial infarction), particularly in hypertensive patients with an enlarged heart (left ventricular hypertrophy).

Composition:

Each film coated tablet contains- Losartan Potassium: 50 mg, Hydrochlorothiazide: 12.5 mg, and Excipients q.s.

Colours: Sunset Yellow & Titanium Dioxide.

Uses & Benefits of Jitolosa HZ 50/12.5 Tablet:

The primary uses of Jitolosa HZ 50/12.5 Tablet include:

• Hypertension (High Blood Pressure): Effectively lowers elevated blood pressure to help prevent long-term damage to vital organs and reduce the heart's workload.
• Prevention of Cardiovascular Morbidity: Reduces the risk of stroke in hypertensive patients who also have left ventricular hypertrophy (LVH). In this condition, the heart's main pumping chamber has become enlarged.

How Does Jitolosa HZ 50/12.5 Tablet Work:

Jitolosa HZ 50/12.5 Tablet works through two distinct mechanisms with the combined action of its two active components to lower blood pressure effectively.

Losartan belongs to a class of medications known as Angiotensin II Receptor Blockers (ARBs). It works by blocking the action of angiotensin II, a hormone that normally causes blood vessels to tighten. By blocking this hormone, blood vessels relax and widen, making it easier for the heart to pump blood.

Hydrochlorothiazide is a thiazide diuretic, also known as a ‘water pill.’ It acts on the kidneys to remove excess salt and water from the body through urine. This reduction in fluid volume helps lower overall blood pressure.

Dosage of Jitolosa HZ 50/12.5 Tablet:

• Usage Direction

Take Jitolosa HZ 50/12.5 Tablet strictly according to your doctor’s instructions, following the prescribed dose and timing. Jitolosa HZ 50/12.5 Tablet should be swallowed whole with water, without breaking, chewing, or crushing it, preferably at the same time each day. Do not stop or alter the dose of Jitolosa HZ 50/12.5 Tablet without consulting your doctor, as this may prevent you from achieving the desired outcome. If you are unsure about the administration procedures of Jitolosa HZ 50/12.5, consult with your doctor or pharmacist.

• Missed Dose

If you miss a dose of Jitolosa HZ 50/12.5 Tablet, take it as soon as you remember on the same day. But, if it is almost time for your next scheduled dose, skip the one you missed and continue following your regular dosing schedule. Do not attempt to take two doses if you have forgotten one. If you often forget to take your medication, consult with your doctor to re-evaluate your dosing schedule. Frequently missing doses could lead to undesired outcomes.

You can set reminders on your smartphone, keep drug organizer boxes, or use other audio-visual technologies to prevent missing a dose.

• Overdose

If you accidentally take Jitolosa HZ 50/12.5 Tablet more than your prescribed dose, contact a doctor immediately or visit the nearest hospital, as this may lead to serious side effects. Symptoms may include low blood pressure, palpitations, dehydration, slow pulse, and changes in blood composition.

Contraindications of Jitolosa HZ 50/12.5 Tablet:

Do not take Jitolosa HZ 50/12.5 Tablet if you are allergic to Losartan, Hydrochlorothiazide, or any sulfonamide-derived medicines. This medicine should not be used in patients with severe liver or kidney impairment, anuria (a condition where the kidneys do not produce urine), gout, low potassium levels (hypokalaemia), low sodium levels (hyponatraemia), or high calcium levels (hypercalcaemia). Always inform your doctor about your complete medical history before starting the treatment.

Precautions & Warnings of Jitolosa HZ 50/12.5 Tablet:

Before starting Jitolosa HZ 50/12.5 Tablet, inform your doctor if you have ever experienced swelling of the face, lips, throat, or tongue (angioedema).

Also let your doctor know you are on a salt-restricted diet, undergoing haemodialysis, have heart failure, narrowing of the kidney arteries, a kidney transplant, atherosclerosis (narrowing of the arteries), angina pectoris (chest pain), or diabetes. Additionally, inform your doctor if you currently have or previously had electrolyte imbalances caused by severe vomiting or diarrhoea.

Side Effects of Jitolosa HZ 50/12.5 Tablet:

Jitolosa HZ 50/12.5 Tablet may cause various side effects, most of which are mild and usually disappear as your body adjusts to the medication. Commonly reported symptoms include dizziness, nausea, diarrhea, stomach pain, tiredness, or weakness. Some individuals may also experience musculoskeletal discomfort, such as back pain, or upper respiratory symptoms similar to a common cold, including a sore throat or nasal congestion.

Some serious reactions require immediate medical attention. Contact your healthcare provider immediately if you experience low blood pressure (hypotension), unexplained weight gain, or peripheral edema (swelling of the legs, ankles, or feet). Other serious concerns include symptoms of jaundice, such as yellowing of the eyes or skin, and signs of eye problems, including eye pain or sudden vision changes. Furthermore, any signs of a severe hypersensitivity reaction such as a skin rash, intense itching, or difficulty breathing should be treated as a medical emergency.

Safety Related Concerns of Jitolosa HZ 50/12.5 Tablet:

• Pregnancy

The use of Jitolosa HZ 50/12.5 Tablet is generally not recommended during pregnancy, as it may potentially harm the developing fetus. If you are pregnant or planning to become pregnant, consult to your doctor before taking this medication.

Label Warning: Fetal Toxicity

When pregnancy is detected, discontinue the product as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.

• Breastfeeding

It is recommended to avoid using Jitolosa HZ 50/12.5 Tablet while breastfeeding. It is currently unknown whether the active ingredients, Losartan and Hydrochlorothiazide, pass into breast milk or how they might affect a nursing infant. Therefore, consulting with your doctor before taking Jitolosa HZ 50/12.5 is crucial to weigh the potential risks.

• Alcohol

Avoid consuming alcohol while taking this medication. Alcohol can enhance the blood-pressure-lowering effect of Jitolosa HZ 50/12.5, significantly increasing the risk of orthostatic hypotension, a sudden drop in blood pressure that occurs when standing up, which may lead to dizziness or fainting.

• Food Interactions

Jitolosa HZ 50/12.5 Tablet is usually suggested to be taken with or without food. However, it is important to limit the intake of high-sodium items, such as seafood, pickles, and salted snacks, as excess dietary salt can worsen hypertension and counteract the medicine's effects.

You should also avoid excessive amounts of potassium-rich foods like bananas or spinach and refrain from using potassium-containing salt substitutes unless directed by a doctor, as Losartan can increase potassium levels in the blood.

Consult your healthcare provider regarding the consumption of grapefruit or grapefruit juice, as it may interfere with how your body processes the medication.

• Drug Interactions

Some medicines may interact with Jitolosa HZ 50/12.5 Tablet and affect how it works. Inform your doctor or pharmacist about all the medicines you are taking, including prescription medicines, over-the-counter drugs, vitamins, minerals, and herbal supplements, to avoid possible drug interactions. These include diuretics (water tablets), potassium supplements or potassium-containing salt substitutes, other blood pressure-lowering medicines, or Aliskiren used for diabetes-related hypertension. Also inform your doctor if you are taking Lithium, NSAIDs such as Ibuprofen or Naproxen, steroid medicines like cortisone or prednisone, glycyrrhizin containing products, oral anti-diabetic medicines, insulin, or cholesterol-lowering medicines such as Cholestyramine.

• Using Machinery & Driving

Jitolosa HZ 50/12.5 Tablet may cause side effects like dizziness, drowsiness, or lightheadedness. Patients should use caution and avoid driving or operating machinery until they are sure the medication does not affect their alertness.

Storage of Jitolosa HZ 50/12.5 Tablet:

Store protected from light & moisture at room temperature. Keep all medicines out of the reach of children.

Avoid using it after the expiry date, printed on the packaging. Dispose of expired or unused medication properly; do not throw it away casually.

Additional Information:

• Regular monitor your blood pressure at home and keep a log for your doctor.
• To enhance the effectiveness of Jitolosa HZ 50/12.5 Tablet and manage hypertension naturally follow a low-salt, low-fat diet, and increase the intake of fresh fruits and vegetables under the supervision of a nutritionist.
• Engaging in regular exercise, moderate physical activity, managing stress, and smoking cessation may help improve your heart rate and stabilize blood pressure.
• In case of overweight, patients must try to maintain an ideal body weight, which can significantly improve their blood pressure.
• Regular monitor your blood pressure at home and keep a log for your doctor. Periodic clinical tests to check your kidney function, liver function, and electrolyte levels (potassium, sodium, and magnesium) are essential, especially if you have pre-existing conditions.
• Do not suddenly stop your medication unless your doctor specifically tells you to.
• Do not share your medicine with someone else having the same symptoms as you.

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Frequently Asked Questions (FAQs):

Q. What are the uses of Jitolosa HZ 50/12.5 Tablet?

A: Jitolosa HZ 50/12.5 Tablet is primarily used to treat and manage high blood pressure (hypertension). It is generally prescribed when a single medication is not sufficient to bring blood pressure levels within the normal range.

Additionally, it helps reduce the risk of serious cardiovascular events, such as stroke, in patients with high blood pressure and an enlarged heart.

Q. Can I stop taking Jitolosa HZ 50/12.5 Tablet if my blood pressure becomes normal?

A: You should not stop taking Jitolosa HZ 50/12.5 Tablet without consulting your doctor, even if your blood pressure readings appear normal. Blood pressure often becomes well controlled because the medicine is working. Stopping it abruptly can cause blood pressure to rise again, increasing the risk of serious complications like stroke or heart attack. Your doctor will guide you on whether and how to safely taper or stop the medicine over time.

Q. Why do I feel dizzy when I stand up quickly?

A: This is a common side effects of Jitolosa HZ 50/12.5 Tablet known as orthostatic hypotension, where blood pressure drops suddenly upon standing. To manage this, you should rise slowly from a sitting or lying position to help prevent fainting. Additionally, avoid consuming alcohol while taking this medication, as it can enhance the blood-pressure-lowering effects and further increase the risk of dizziness or fainting.

Q. Do I need regular blood tests while on this medicine?

A: Yes, your doctor will likely monitor your kidney function and electrolyte levels, such as potassium and sodium, periodically. Regular monitoring is important because Jitolosa HZ 50/12.5 Tablet can influence how your kidneys function and affect the balance of salts in your body. Providing a complete medical history regarding any existing renal impairment or electrolyte imbalances is essential for your healthcare provider to manage these checks effectively.

Reference:

1. Package leaflet: Information for the patient. Losartan/Hydrochlorothiazide 50 mg/ 12.5 mg and 100 mg/ 25 mg film-coated tablets. Last Revised: June, 2021. Accessed on: 11th May 2026. Click Here

2. Patient Information. Losartan Potassium and Hydrochlorothiazide Tablets, USP. 50 mg/12.5 mg, 100 mg/12.5 mg and 100 mg/25 mg. Last Revised: May 2023. Accessed on: 11th May 2026. Click Here

3. Losarzed H. Losartan Potassium and Hydrochlorothiazide Tablets USP. Last Revised: December 2016. Accessed on: 11th May 2026. Click Here