Jitolosa AM 50/5 Tablet (10 Tab)

Jitolosa AM 50/5 Tablet Overview:

Jitolosa AM 50/5 Tablet is a fixed-dose combination antihypertensive medication used to treat essential hypertension (high blood pressure) when single-agent therapy is not sufficient to lower blood pressure.

Hypertension is a progressive condition that puts chronic strain on the heart and vascular network. If left untreated, long-term high pressure damages vital blood vessels over time, substantially elevating the risk of cardiovascular events such as stroke, myocardial infarction (heart attack), and heart or renal failure.

The medication combines two active ingredients—Losartan (an Angiotensin II Receptor Blocker or ARB) that prevents blood vessel constriction and reduces fluid retention, and Amlodipine (a Calcium Channel Blocker or CCB) that relaxes arterial smooth muscles.

By working through two distinct mechanisms simultaneously, Jitolosa AM Tablet dilates blood vessels, improves blood flow, and helps maintain stable blood pressure.

Composition:

Each film coated tablet contains- Losartan Potassium: 50 mg and Amlodipine Besilate Equivalent to Amlodipine: 5 mg.

Colours: Ferric Oxide Yellow and Titanium Dioxide

Uses & Benefits of Jitolosa AM 50/5 Tablet:

The therapeutic uses and benefits of Jitolosa AM 50/5 Tablet include:

• Management of Uncontrolled Hypertension: Indicated for adult patients whose blood pressure is not adequately controlled on monotherapy (either amlodipine or losartan alone).
• Reduction of Cardiovascular Risk: Helps prevent long-term complications associated with chronic hypertension, including strokes, myocardial infarction (heart attacks), and chronic kidney disease.

How Does Jitolosa AM 50/5 Tablet Work:

Jitolosa AM 50/5 Tablet contains two active salts, Losartan and Amlodipine, which work through two distinct mechanisms to lower blood pressure effectively.

Losartan is classified as an Angiotensin II Receptor Blocker (ARB). It selectively blocks the binding of angiotensin II (a potent endogenous vasoconstrictor) to the AT1 receptor in vascular smooth muscle and adrenal glands. This prevents vasoconstriction and reduces aldosterone secretion, relaxing blood vessels and lowering fluid retention.

Furthermore, Amlodipine is a long-acting dihydropyridine Calcium Channel Blocker (CCB). It inhibits the influx of extracellular calcium ions into vascular smooth muscle and cardiac muscle cells. This prevents muscle contraction, causing arterial vasodilation and reducing peripheral vascular resistance.

Dosage of Jitolosa AM 50/5 Tablet:

• Usage Directions

Take Jitolosa AM 50/5 Tablet strictly according to your doctor’s instructions, following the prescribed dose and timing. Jitolosa AM Tablet should be swallowed whole with water and not chewed, cut, or crushed, preferably at the same time each day. Do not stop or alter the dose of Jitolosa AM 50/5 Tablet without consulting your doctor, as this may prevent you from achieving the desired outcome. If you aren't sure how to take Jitolosa AM, check with your healthcare provider or pharmacist for instructions.

• Missed Dose

If you miss a dose of Jitolosa AM 50/5 Tablet, take it as soon as you remember on the same day. If it's almost time for your next dose, skip the missed dose and proceed with your usual routine. Do not take a double dose if you have forgotten one.

To help remember your daily dose, try setting phone alarms, using a pill organizer box, or utilizing medication reminder apps.

• Overdose

If you accidentally take Jitolosa AM 50/5 Tablet more than your prescribed dose, seek immediate medical advice or contact a poison control center. An overdose may cause severe hypotension (excessively low blood pressure), dizziness, fainting, tachycardia, or bradycardia.

Contraindications of Jitolosa AM 50/5 Tablet:

Do not take Jitolosa AM 50/5 Tablet if you have a known allergy or hypersensitivity to Losartan, Amlodipine, or any other inactive component present in this medication. It must not be used in patients with severe hepatic impairment, cirrhosis, or biliary obstructive disorders.

Additionally, the medication should be avoided in individuals with severe hypotension, cardiogenic shock, hemodynamically unstable heart failure following an acute myocardial infarction, or severe aortic stenosis.

Concomitant use with aliskiren is strictly contraindicated in patients diagnosed with diabetes mellitus or moderate-to-severe kidney disease.

Furthermore, safety and efficacy have not been established in pediatric patients, so it is not recommended for children and adolescents under 18 years of age.

Precautions & Warnings of Jitolosa AM 50/5 Tablet:

Before starting treatment with Jitolosa AM 50/5 Tablet, inform your healthcare provider about your complete medical history, any pre-existing kidney or mild-to-moderate liver disease, as dosage adjustment and close monitoring may be required.

Caution is advised in patients with cardiovascular conditions such as severe aortic stenosis, severe coronary artery disease, or obstructive hypertrophic cardiomyopathy.

Inform your physician immediately if you experience persistent vomiting, diarrhea, or significant volume depletion, which can increase the risk of severe symptomatic hypotension. Seek emergency medical attention if you develop signs of angioedema—such as swelling of the face, lips, tongue, or throat, or difficulty breathing—as this requires immediate discontinuation of the drug.

Additionally, routine monitoring of blood pressure, renal function markers (serum creatinine, eGFR), and serum electrolyte levels (specifically potassium) is recommended throughout therapy to detect potential electrolyte imbalances.

Side Effects of Jitolosa AM 50/5 Tablet:

Jitolosa AM 50/5 Tablet can cause some side effects, although not everyone will experience them. Common symptoms include peripheral edema (swelling of ankles or feet), dizziness, headache, flushing, fatigue, and nausea.

Uncommon or rare side effects include hyperkalemia, palpitations, orthostatic hypotension, cough, rash, gastrointestinal disturbances, and muscle cramps.

However, seek immediate medical attention if you experience any serious side effects, such as low blood pressure (feeling of faintness, light-headedness), shortness of breath, breathing difficulty, rapid or abnormal heartbeat, and severe allergic reactions (itching, swelling of eyelids, face, lips, tongue, and throat).

Safety Related Concerns Of Jitolosa AM 50/5 Tablet:

• Pregnancy

Jitolosa AM 50/5 Tablet must be avoided during pregnancy due to the potential risk of fetal damage from Losartan and Amlodipine. If you are pregnant, planning to become pregnant, or suspect you might be, consult your doctor immediately to transition to a safer alternative for managing your blood pressure.

• Breastfeeding

It is best to avoid using Jitolosa AM 50/5 Tablet while breastfeeding, since one of its active ingredients, Amlodipine, passes into human breast milk and may affect the nursing infant. Therefore, consult with your doctor before taking the medicine.

• Alcohol

Alcohol consumption should be avoided or strictly limited while taking Jitolosa AM 50/5 Tablet, as it potentiates the blood pressure-lowering effect, causing sudden dizziness, lightheadedness, or fainting.

• Food Interactions

Take Jitolosa AM Tablet with or without food, as advised by the physician. Avoid consuming grapefruit or grapefruit juice, as it can increase the systemic bioavailability of amlodipine and intensify hypotensive effects.

If you have any known food allergies, dietary restrictions, or severe digestive issues, inform your healthcare provider before starting the medication.

• Drug Interactions

Jitolosa AM 50/5 Tablet may interact with other medicines, either by compromising their effectiveness or increasing the risk of toxicity. Avoid combining this medicine with ACE inhibitors, aliskiren, potassium-sparing diuretics, or potassium supplements, as these combinations can cause dangerously low blood pressure, high potassium levels, or kidney damage.

Moreover, pain relievers (NSAIDs) may reduce its effectiveness and harm kidney function, while lithium taken alongside this drug increases the risk of lithium toxicity.

Additionally, potent CYP3A4 inhibitors (such as ketoconazole, clarithromycin, and certain antifungals or antivirals) and inducers (such as rifampicin and phenytoin) can alter amlodipine metabolism, leading to excessive drug accumulation or reduced efficacy.

Caution and dosage monitoring are also required when co-administering with other vasodilators, non-dihydropyridine calcium channel blockers (verapamil, diltiazem), immunosuppressants (cyclosporine, tacrolimus), and specific cholesterol-lowering agents like simvastatin.

Always inform your healthcare provider and pharmacist about all medications you are taking, including prescription drugs, over-the-counter medications, St.John’s wort, vitamins, and minerals, especially potassium-rich supplements, to avoid potential interactions.

• Using Machinery & Driving

Jitolosa AM 50/5 Tablet may cause dizziness, drowsiness, or lightheadedness in some individuals. Patients should avoid driving or operating machinery until they are sure the medication does not affect their alertness.

Storage of Jitolosa AM 50/5 Tablet:

Store protected from light and moisture, at a temperature not exceeding 25°C. Keep all medicines out of reach of children.

Do not consume this medicine past the expiration date stated on the package. Dispose of expired or unused medications properly without throwing them away casually.

Helpful Tips:

• Regular follow-up with your healthcare provider.
• Blood pressure should be monitored regularly to ensure the medication is working effectively and to adjust dosing as needed.
• Your doctor may also periodically monitor your kidney function, liver function, and electrolyte levels, particularly if you have pre-existing conditions that affect these organs.
• Lifestyle modifications include maintaining a healthy weight, engaging in regular physical activity, following a heart-healthy diet low in sodium and rich in potassium, limiting alcohol consumption, quitting smoking, managing stress effectively, and getting adequate sleep.
• Do not stop taking your medication suddenly unless your doctor specifically instructs you.
• Never share your medicine with others, even if they have similar symptoms, because this is a prescription drug tailored specifically for you.

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Frequently Asked Questions (FAQs):

Q: What is Jitolosa AM 50/5 Tablet used for?

A: Jitolosa AM 50/5 Tablet is a prescription medication used to treat high blood pressure (hypertension) in adults whose blood pressure is not adequately controlled with a single medicine alone.

Q: Can I stop taking Jitolosa AM 50/5 if my blood pressure returns to normal?

A: No. Normal blood pressure readings mean the medication is working properly. Stopping the medicine abruptly can cause your blood pressure to spike (rebound hypertension). Always consult your doctor before changing your dose or stopping treatment.

Q: Why are my ankles swollen after taking this medicine?

A: Ankle and foot swelling (peripheral edema) is a common side effect of amlodipine, one of the active ingredients in this medication. It occurs because the drug relaxes blood vessels, allowing fluid to pool in the lower extremities. Elevating your legs while resting can help reduce mild swelling, but you should consult your doctor if it becomes persistent, uncomfortable, or severe.

Q: Is Jitolosa AM 50/5 Tablet safe for long-term use?

A: Yes. Jitolosa AM 50/5 is formulated for the long-term management of chronic high blood pressure. Because hypertension is typically a lifelong condition, this medicine should be taken continuously as prescribed, alongside routine medical check-ups to monitor your blood pressure and kidney function.

Q: Can I take potassium supplements or use potassium-based salt substitutes with this medicine?

A: No, because Losartan has the potential to elevate serum potassium levels. Combining it with potassium supplements or low-sodium salt substitutes containing potassium can cause hyperkalemia (dangerously high blood potassium), which can affect heart rhythm. Always consult your doctor before using salt substitutes.

Q: Will Jitolosa AM 50/5 Tablet cause dizziness when I stand up?

A: Dizziness or lightheadedness can occur, especially when starting the medication or adjusting the dose (orthostatic hypotension). To minimize this, get up slowly from a sitting or lying position. If severe dizziness persists, contact your doctor.

Q: Can Jitolosa AM Tablet affect my sex life or cause erectile dysfunction?

A: Sexual dysfunction is rare with this combination. Losartan generally has a neutral or sometimes favorable profile regarding sexual function compared to older blood pressure drugs like beta-blockers or high-dose thiazide diuretics. Consult your healthcare provider if you experience any symptoms of sexual dysfunction during treatment.

Q: Does Jitolosa AM 50/5 cause weight gain?

A: The medication does not cause fat-related weight gain. However, if you notice a sudden increase in weight alongside swelling in your ankles, feet, or lower legs, it is likely fluid retention (peripheral edema) caused by the amlodipine component. Inform your doctor if fluid retention becomes noticeable.

References:

1. Jitolosa AM 50/5. Losartan Potassium and Amlodipine Tablets. Accessed on: 3rd September 2026. Click Here

2. Eslo Tan® Tablets. S(-) Amlodipine 2.5 mg + Losartan Potassium 50 mg tablets. Package leaflet: Information for the patient. Last Revised: 06/2023. Accessed on: 3rd September 2026. Click Here

3. TOZAM. Losartan potassium and Amlodipine Tablets I.P. Last Revised: FEB 2026. Accessed on: 3rd September 2026. Click Here

4. AMPACE L. Amlodipine & Losartan Potassium Tablets IP. Accessed on: 3rd September 2026. Click Here