Jitoglim PIME 2/15/500 Tablet (10 Tab)

Jitoglim PIME 2/15/500 Tablet Overview:

Jitoglim PIME 2/15/500 Tablet is an oral anti diabetic medication used for adults with type 2 diabetes mellitus.

It is recommended when dietary changes, physical activity, and previous single or dual oral therapy fail to maintain adequate blood glucose levels.

Jitoglim PIME 2/15/500 Tablet works by improving the body’s response to insulin and stimulating insulin production, helping prevent severe symptoms linked to uncontrolled diabetes.

Jitoglim PIME 2/15/500 Tablet supports glycemic control through multiple mechanisms of action, which helps lower the chances of diabetes-related complications such as heart disease, nerve damage, and kidney problems.

It should be noted that this medication is not intended for type 1 diabetes management and is not considered a first-line treatment.

Composition:

Each uncoated bilayered tablet contains- Metformin Hydrochloride (Prolonged Release form): 500 mg, Glimepiride: 2 mg, Pioglitazone Hydrochloride Equivalent to Pioglitazone: 15 mg, and Excipients q.s.

Colour: Lake Quinoline Yellow.

Uses & Benefits of Jitoglim PIME 2/15/500 Tablet:

Jitoglim PIME 2/15/500 Tablet is primarily used for the treatment of Type 2 diabetes mellitus or non-insulin-dependent diabetes mellitus (NIDDM).

How Jitoglim PIME 2/15/500 Tablet Works:

Jitoglim PIME 2/15/500 Tablet contains three medicines, Glimepiride, Metformin, and Pioglitazone, that work together to control high blood sugar in people with type 2 diabetes.

Glimepiride helps your pancreas release more insulin, especially after meals, so the sugar in your blood can be used properly.

Metformin reduces the amount of sugar made by the liver, slows down sugar absorption from food, and helps your body use insulin more efficiently.

Pioglitazone improves how your muscles and fat cells take in and store sugar, which lowers insulin resistance.

By targeting diabetes from different angles, this triple-action formula provides stronger and more stable blood sugar control both after eating and during fasting.

Dosage of Jitoglim PIME 2/15/500 Tablet:

• Usage Directions

To maximize effectiveness, swallow Jitoglim PIME 2/15/500 Tablet whole with a glass of water, preferably with meal. It should not be crushed, chewed, or split, as this could alter absorption and increase side effect risks. Doctors typically start with this dose for moderate hyperglycemia, adjusting based on weekly blood sugar monitoring. Combine it with a balanced, low-glycemic diet rich in fiber, lean proteins, and vegetables, alongside moderate exercise weekly. For Jitoglim PIME 2/15/500 Tablet usage directions, always follow your healthcare provider's instruction, as individual factors like age, weight, and concurrent conditions influence timing.

• Missed Dose

If you forget a dose of Jitoglim PIME 2/15/500 Tablet, take it as soon as you remember, if it is not close to your next scheduled dose. Skipping a single dose is unlikely to cause major fluctuations in well-controlled diabetes, but resuming promptly prevents cumulative effects on blood sugar. Never double up to compensate, as this heightens hypoglycemia risk from excess Glimepiride. Set phone reminders or use pill organizers to maintain consistency, especially during busy days. In cases of frequent misses, discuss with your doctor, who may recommend alternative strategies like splitting doses.

• Overdose

An overdose of Jitoglim PIME 2/15/500 Tablet can lead to severe hypoglycemia, characterized by symptoms like profuse sweating, tremors, confusion, rapid heartbeat, and in extreme cases, seizures or coma, primarily due to amplified Glimepiride effects. Metformin excess might cause lactic acidosis, marked by muscle pain, breathing difficulty, and nausea, while Pioglitazone overdose is rarer but could exacerbate fluid retention. Seek emergency medical help immediately—call your local poison control or head to the nearest hospital. Treatment often involves oral glucose for mild cases or IV dextrose and monitoring for acidosis. Preventive measures include secure storage away from children. Understanding Jitoglim PIME 2/15/500 Tablet overdose protocols is crucial for safety in households with multiple users.

• Contraindications of Jitoglim PIME 2/15/500 Tablet:

Jitoglim PIME 2/15/500 Tablet is not suitable for everyone and should be avoided in cases of type 1 diabetes, diabetic ketoacidosis, or severe infections requiring insulin. It's contraindicated in patients with hypersensitivity to any component, such as sulfa allergies for Glimepiride. Severe renal impairment (eGFR below 30 mL/min) rules out Metformin due to lactic acidosis risk, while Pioglitazone is off-limits for those with active bladder cancer, NYHA Class III/IV heart failure, or severe liver disease (ALT >2.5 times upper limit). Pre-existing conditions like brittle diabetes or recent myocardial infarction also warrant avoidance. Always disclose full medical history before starting, as contraindications for Jitoglim PIME 2/15/500 Tablet ensure targeted, risk-free use.

• Precautions & Warnings of Jitoglim PIME 2/15/500 Tablet:

Before initiating Jitoglim PIME 2/15/500 Tablet, undergo baseline tests for kidney function (serum creatinine), liver enzymes, and heart status via ECG if needed. Monitor blood glucose frequently during dose adjustments to catch hypoglycemia early, particularly in elderly patients or those on low-carb diets. Pioglitazone may cause macular edema, so regular eye exams are advised for those with retinopathy. Metformin's GI tolerance improves over time, but start low if prone to nausea. Warn against abrupt discontinuation, which can provoke hyperglycemia rebound. Inform your doctor of any fever, surgery, or contrast dye use, as these may necessitate temporary pauses. Hydration is key to support renal clearance.

• Side Effects of Jitoglim PIME 2/15/500 Tablet:

Common side effects of Jitoglim PIME 2/15/500 Tablet include mild gastrointestinal upset like nausea, diarrhea, or bloating from Metformin, affecting up to 20% initially but often resolving within weeks. Headache, dizziness, or a metallic taste may occur, alongside Pioglitazone-related mild weight gain (1-2 kg) or ankle swelling in 5-10% of users. Hypoglycemia, though less frequent than with sulfonylureas alone, presents as shakiness or hunger and affects about 15% in combination studies. Serious effects, rare under 1%, encompass lactic acidosis (Metformin), heart failure worsening (Pioglitazone), or severe allergic reactions like rash or breathing issues. Most resolve with dose tweaks or supportive care. Searches for Jitoglim PIME 2/15/500 Tablet side effects highlight the importance of reporting persistent symptoms promptly to adjust therapy.

Safety Related Concerns of Jitoglim PIME 2/15/500 Tablet:

• Pregnancy

Jitoglim PIME 2/15/500 Tablet is generally not recommended during pregnancy due to limited safety data and potential risks to fetal development. Glimepiride crosses the placenta and may cause neonatal hypoglycemia, while Pioglitazone has shown skeletal anomalies in animal studies. Metformin is sometimes used in gestational diabetes but requires close monitoring. Switch to insulin if conception is planned, as per guidelines. Consult your obstetrician for Jitoglim PIME 2/15/500 Tablet pregnancy advice, prioritizing maternal-fetal health through tailored alternatives.

• Breastfeeding

Caution is advised with Jitoglim PIME 2/15/500 Tablet during breastfeeding, as Metformin appears in breast milk in small amounts, potentially causing infant GI discomfort or altered glucose levels. Glimepiride and Pioglitazone data are sparse, but sulfonylureas can lead to baby hypoglycemia. Weigh benefits against risks; pumping and discarding milk post-dose or opting for insulin may be safer. Discuss with a lactation specialist for personalized Jitoglim PIME 2/15/500 Tablet breastfeeding guidance.

• Alcohol

Avoid alcohol while on Jitoglim PIME 2/15/500 Tablet, as it amplifies hypoglycemia risk by inhibiting gluconeogenesis, especially with Metformin, and may provoke lactic acidosis. Even moderate intake can mask low sugar symptoms, leading to accidents. If social drinking occurs, monitor glucose closely and eat carbs beforehand. For Jitoglim PIME 2/15/500 Tablet alcohol interactions, abstinence supports safer diabetes control.

• Using Machinery & Driving

Jitoglim PIME 2/15/500 Tablet users should exercise caution with driving or operating machinery, particularly if prone to hypoglycemia, which impairs alertness and reaction times. Symptoms like blurred vision or drowsiness from low sugar mimic fatigue. Test glucose before tasks and carry quick carbs. Stable users face minimal issues, but new starters need adaptation time. Prioritize safety in Jitoglim PIME 2/15/500 Tablet using machinery & driving scenarios.

• Food Interactions

Take Jitoglim PIME 2/15/500 Tablet with food to buffer GI effects and optimize absorption—avoid high-fat meals that delay onset. Grapefruit or excessive alcohol-rich foods heighten risks, while fiber-rich diets enhance Metformin's efficacy. No major conflicts with common foods, but consistent timing aids control. Explore Jitoglim PIME 2/15/500 Tablet food interactions for dietary harmony.

• Drug Interactions

Jitoglim PIME 2/15/500 Tablet may interact with beta-blockers, masking hypoglycemia; NSAIDs or ACE inhibitors, stressing kidneys with Metformin; or rifampin, reducing Pioglitazone levels. Enhance effects with other antidiabetics like insulin, risking lows. CYP2C9 inhibitors like fluconazole boost Glimepiride. Review all meds with your pharmacist for Jitoglim PIME 2/15/500 Tablet drug interactions.

Storage Instructions:

Store below 25°C. Protect from light & moisture. Keep out of children's reach and discard after expiry.

Other Notes:

• Include regular physical activity to improve blood sugar control.

• Cut down on foods high in saturated fats, trans fats, refined carbs, and added sugar to manage glucose and weight.

• Maintain a healthy body weight to enhance insulin sensitivity.

• Avoid smoking.

• Attend all scheduled medical check-ups to monitor progress and prevent diabetes complications.

• Use apps or glucose trackers to monitor progress.

Related Blood Glucose Monitors:

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Frequently Asked Questions (FAQs):

Q1. What is Jitoglim PIME 2/15/500 Tablet used for?

A. Jitoglim PIME 2/15/500 Tablet is primarily prescribed for managing type 2 diabetes in adults when diet, exercise, and single medications aren't enough to control blood sugar. It combines three active ingredients to lower glucose levels, reduce the risk of complications like heart disease or nerve damage, and improve overall daily energy and well-being.

Q2. How should I take Jitoglim PIME 2/15/500 Tablet?

A. Take one tablet whole with a full glass of water, preferably with your first main meal of the day to minimize stomach upset and optimize absorption. Do not crush, chew, or split it due to its extended-release formula. Always follow your doctor's dosage instructions and pair it with a balanced diet and regular physical activity for the best results.

Q3. What are the common side effects of Jitoglim PIME 2/15/500 Tablet?

A. Mild side effects may include nausea, diarrhea, or bloating from the metformin component, which often improve after a few weeks. You might also notice slight weight gain or swelling in the ankles from pioglitazone, or low blood sugar symptoms like shakiness if meals are skipped. If any persist or worsen, contact your doctor right away.

Q4. Can I drink alcohol while taking Jitoglim PIME 2/15/500 Tablet?

A. It's best to avoid alcohol, as it can increase the risk of low blood sugar or lactic acidosis, especially with the metformin in the tablet. If you do drink occasionally, monitor your glucose closely, eat a carb-rich snack, and discuss limits with your healthcare provider to stay safe.

Q5. Is Jitoglim PIME 2/15/500 Tablet safe during pregnancy or breastfeeding?

A. Jitoglim PIME 2/15/500 Tablet is not recommended during pregnancy due to potential risks to the baby, such as low blood sugar at birth. For breastfeeding, small amounts may pass into milk, possibly affecting the infant's glucose levels—switch to insulin if needed and consult your doctor for personalized advice.

Q6. What should I do if I miss a dose of Jitoglim PIME 2/15/500 Tablet?

A. If you miss a dose, take it as soon as you remember, but skip it if it's almost time for your next one—never double up to avoid low blood sugar risks. Use reminders like apps or alarms to stay consistent, and inform your doctor if missing doses happens often for possible adjustments.

Q7. Does Jitoglim PIME 2/15/500 Tablet interact with other medications?

A. Yes, it can interact with drugs like beta-blockers (which hide low sugar signs), NSAIDs (affecting kidneys), or other diabetes meds (increasing hypoglycemia risk). Always share your full medication list with your pharmacist or doctor before starting to prevent issues and ensure safe use.

Q8. How long does it take for Jitoglim PIME 2/15/500 Tablet to start working?

A. You may see blood sugar improvements within 1-2 weeks, but full benefits, like better HbA1c levels, often take 4-8 weeks with consistent use, diet, and exercise. Regular monitoring helps track progress—discuss any delays with your doctor for tweaks.

References:

1. Glimepiride, Pioglitazone & Metformin Hydrochloride Extended release Tablets Amaryl® MP 1mg and 2mg. Last Updated: November 2022. Accessed On: 9th September 2025. Click Here

2. Pioglitazone Hcl with Glimepiride and Metformin Hcl Sustained Release Tablets. Accessed On: 9th September 2025. Click Here