Jitoglic ME 60/500 Tablet (10 Tab)

Jitoglic ME 60/500 Tablet Overview:

Jitoglic ME 60/500 Tablet is an oral anti-diabetic combination medication used to manage type 2 diabetes mellitus.

Type 2 diabetes mellitus, also referred to as non-insulin-dependent diabetes mellitus, is a metabolic condition that occurs when the body either does not produce enough insulin or cannot effectively use the insulin it produces. This leads to chronically elevated blood glucose levels, which can cause severe, long-term health complications if left unmanaged.

Jitoglic ME 60/500 Tablet combines two active ingredients that provide comprehensive glycemic control when diet, exercise, and weight loss alone are insufficient.

The first component, Gliclazide, is a sulfonylurea that stimulates insulin secretion from the pancreas. The second component, Metformin, is a biguanide that reduces glucose production in the liver while simultaneously improving peripheral insulin sensitivity.

By combining these dual-action mechanisms, the medication effectively maintains stable blood glucose levels throughout the day while minimizing the risk of sudden, dangerous drops in blood sugar.

It is important to note that, Jitoglic ME 60/500 Tablet is not used for treating Type 1 diabetes mellitus or diabetic ketoacidosis.

Composition:

Each uncoated bilayered extended-release tablet contains- Gliclazide (in extended release form): 60 mg, Metformin Hydrochloride (in extended release form): 500 mg, and Excipients q.s.

Colour: Ponceau 4R Lake

Uses & Benefits of Jitoglic ME 60/500 Tablet:

Jitoglic ME 60/500 Tablet is indicated for the management and treatment of Type 2 Diabetes Mellitus, also known as non-insulin-dependent diabetes mellitus (NIDDM).

How Does Jitoglic ME 60/500 Tablet Work:

The two active ingredients in Jitoglic ME 60/500 Tablet work synergistically to regulate blood glucose levels through distinct pathways.

Gliclazide, a sulfonylurea, acts directly on the beta cells of the pancreas to stimulate the secretion of insulin, the essential hormone that allows glucose to transition from the bloodstream into body cells for energy production.

Simultaneously, Metformin Hydrochloride, a biguanide, predominantly reduces the amount of glucose produced and released by the liver. Additionally, Metformin delays glucose absorption within the intestines and enhances peripheral insulin sensitivity, helping the body's cells utilize available glucose far more efficiently.

Dosage of Jitoglic ME 60/500 Tablet:

• Usage Direction

Take Jitoglic ME 60/500 Tablet strictly according to your doctor’s instructions, following the prescribed dose and timing. Jitoglic ME 60/500 Tablet should be swallowed whole and not to be chewed, or cut, or crushed, preferably at the same time each day. Do not stop or alter the dose of Jitoglic ME 60/500 Tablet without consulting your doctor, as this may prevent you from achieving the desired outcome. If you are unsure about the administration procedures of Jitoglic ME 60/500, consult with your doctor or pharmacist.

• Missed Dose

In case you forget to take a dose of Jitoglic ME 60/500 Tablet, take it as soon as you remember on that day. If it's nearly time for your next dose, simply skip the missed dose and proceed with your normal dosing schedule. Do not attempt to take two doses if you have forgotten one. If you often frequently forget your medication, consult your doctor to reassess your dosing plan. Missing doses frequently can lead to undesired outcomes.

To prevent missing a dose, you might set reminders on your smartphone, use medication organizer boxes, or use other audio-visual technologies.

• Overdose

If you accidentally take Jitoglic ME 60/500 Tablet more than your prescribed dose, seek immediate medical attention or contact an emergency room. An overdose can cause severe hypoglycemia (dangerously low blood sugar) or a rare but critical condition called lactic acidosis. Symptoms of overdose include extreme weakness, blurred vision, sweating, trembling, confusion, severe headache, rapid breathing, nausea, or vomiting.

Contraindications of Jitoglic ME 60/500 Tablet:

Do not take Jitoglic ME 60/500 Tablet if you have a known allergy or hypersensitivity to Gliclazide, Metformin, other sulfonylureas, or any inactive components of this medication. It must not be used by patients who have type 1 diabetes mellitus, severe ketosis, metabolic acidosis, or diabetic ketoacidosis.

Furthermore, this medication is not recommended for individuals with severe kidney disease, liver failure, or acute conditions that can affect renal function—such as severe dehydration, shock, or serious infections.

Jitoglic ME 60/500 is also not recommended for patients with unstable or severe cardiopulmonary conditions, including chronic obstructive pulmonary disease (COPD), coronary heart disease, cardiac failure, or peripheral vascular disease.

Additionally, this medication should not be used in pediatric populations, as its safety and effectiveness in children have not been established.

Precautions & Warnings of Jitoglic ME 60/500 Tablet:

Before starting Jitoglic ME 60/500 Tablet, it is crucial to exercise caution, as accidental overdose may lead to severe hypoglycemia. The Metformin component is associated with a rare but severe risk of lactic acidosis, which is a dangerous increase of lactic acid in the blood, particularly in individuals with compromised kidney or liver function.

To eradicate these risks, patients must regularly monitor their blood glucose levels and undergo routine HbA1c, kidney function, and liver function assessments as directed by their healthcare provider.

Furthermore, because the Gliclazide component actively stimulates insulin secretion, it is critical not to skip or delay meals after taking this medication to prevent blood sugar from dropping too low. Patients should always carry a fast-acting source of sugar, such as fruit juice, candy, or glucose powder, to promptly manage any sudden symptoms of hypoglycemia.

Side Effects of Jitoglic ME 60/500 Tablet:

While Jitoglic ME 60/500 Tablet is generally well tolerated, a primary side effect of this medication is hypoglycemia (low blood sugar), which typically presents with dizziness, sweating, tremors, and shaking.

Commonly reported side effects include nausea, vomiting, diarrhea, abdominal pain, taste disturbances (metallic taste in the mouth), headache, fever, chills, cough, hoarseness, and mild upper respiratory tract irritation.

Although rare, certain severe adverse reactions require immediate medical intervention. Patients must seek urgent care if they exhibit symptoms of lactic acidosis (such as deep, rapid breathing, persistent vomiting, and severe abdominal pain), signs of liver distress like jaundice (yellowing of the skin or eyes), or severe allergic reactions including skin rashes, intense itching (pruritus), hives (urticaria), and swelling (angioedema).

Safety Related Concerns of Jitoglic ME 60/500 Tablet:

• Pregnancy

Jitoglic ME 60/500 Tablet is generally not recommended for use during pregnancy, as limited data exists regarding the combined safety of Gliclazide and Metformin, and it may pose a risk of harm to the developing fetus. If you are pregnant or planning a pregnancy, consult your healthcare provider immediately. Your healthcare provider may switch to insulin or other safer alternatives to maintain normal blood sugar levels.

• Breastfeeding

It is recommended to avoid using Jitoglic ME 60/500 Tablet while breastfeeding, as both Gliclazide and Metformin can pass into breast milk and potentially cause adverse effects in the nursing infant. Patients should consult their healthcare provider before taking this medication for managing blood glucose levels while lactating.

• Alcohol

Avoid alcohol consumption while taking Jitoglic ME 60/500 Tablet, as it may significantly increases the risk of severe hypoglycemia and elevates the risk of developing dangerous lactic acidosis.

• Food Interactions

Jitoglic ME 60/500 Tablet can be taken with or without food. Your doctor may prescribe it with or after a meal, as it might help reduce gastrointestinal side effects, and taking it on an empty stomach may lead to sudden drops in blood glucose.

However, maintaining a healthy diet is essential for regulating blood glucose levels by avoiding sugary items and high-fat foods and by limiting carbohydrates, as these are primarily responsible for glucose spikes and gastrointestinal side effects. Focusing on nutrient-dense, fiber-rich foods helps regulate the rate of sugar absorption, thereby enhancing the overall effectiveness of the treatment.

• Drug Interactions

Jitoglic ME 60/500 Tablet may interact with various medications, potentially altering its efficacy or increasing side effects. Concurrent use of insulin, acarbose, sulfonamides, ACE inhibitors, MAOIs, H2-antagonists, fluconazole, NSAIDs, anticoagulants, or beta-blockers, which may mask hypoglycemia symptoms, significantly increases the risk of low blood sugar.

Conversely, corticosteroids and diuretics may elevate blood glucose, opposing treatment efficacy.

Concurrently using estrogens, oral contraceptives, phenytoin, or quinolones requires clinical monitoring, as dosage adjustments may be necessary.

Always inform your healthcare provider of all current prescription medications, over-the-counter drugs, and herbal supplements before beginning treatment.

• Using Machinery & Driving

Jitoglic ME 60/500 Tablet itself does not cause drowsiness, unless your blood sugar drops too low (hypoglycemia), which can cause dizziness, blurred vision, or confusion, impairing your coordination and driving abilities. Do not drive or operate machinery unless your blood sugar levels are stable.

Storage of Jitoglic ME 60/500 Table:

Store protected from light & moisture at a temperature not exceeding 25°C. Keep the medicine out of reach of children.

Avoid using it after the expiry date, printed on the packaging. Properly dispose of any expired or unused medications; do not throw it away casually.

Additional Information:

• Focus on complex carbohydrates, high-fiber foods (whole grains, vegetables, legumes), and lean proteins.
• Limit the intake of refined sugars, sugary beverages, and processed foods to avoid sudden glucose spikes.
• Engage in at least 30 minutes of moderate exercise (such as brisk walking, swimming, or cycling) most days of the week to naturalize insulin absorption and control weight.
• Always keep a small snack or fast-acting sugar source on hand. Do not delay meals after taking your daily dose.
• Avoid stopping your medication suddenly unless instructed by your physician.
• Do not give your medicine to someone else who has the same symptoms.

Frequently Asked Questions (FAQs):

Q: What is the use of Jitoglic ME 60/500 Tablet?

A: Jitoglic ME 60/500 Tablet is a combination oral anti-diabetic medication containing Gliclazide and Metformin. It is primarily prescribed to manage type 2 diabetes mellitus by helping to control and maintain stable blood glucose levels when diet, exercise, and single-drug therapies are insufficient.

Q: Can I stop taking Jitoglic ME 60/500 Tablet if my blood sugar levels return to normal?

A: No, you should never discontinue this medication abruptly without consulting your doctor. Normal blood sugar levels indicate that the treatment is working effectively; stopping it can cause a rapid rebound spike in blood glucose, increasing the risk of long-term diabetic complications.

Q: Does long-term use of this medicine cause Vitamin B12 deficiency?

A: Yes, the Metformin component can interfere with Vitamin B12 absorption during prolonged use. If you experience symptoms such as tingling in your hands or feet, weakness, or unexplained fatigue, inform your doctor so they can monitor your B12 levels or recommend appropriate supplements.

Q: Will Jitoglic ME 60/500 Tablet cause weight gain?
A: Yes, it can, but the effect is often minimized. The Gliclazide component stimulates insulin secretion, which can increase fat storage and appetite, potentially leading to weight gain. However, the Metformin component is weight-neutral or promotes modest weight loss, which helps counteract and balance this effect. However, if you notice significant weight fluctuation, it is essential to consult your doctor right away.

Q: Who should avoid taking Jitoglic ME 60/500 Tablet?
A: Jitoglic ME 60/500 Tablet should be strictly avoided if you have a known allergy to Gliclazide, Metformin, or any of its inactive components. It is also contraindicated for individuals with type 1 diabetes, diabetic ketoacidosis, severe kidney or liver impairment, and acute conditions like severe dehydration or shock. Furthermore, because of the risk of lactic acidosis, it should be avoided by patients with severe cardiopulmonary conditions (such as heart failure or COPD), as well as those who are pregnant, breastfeeding, or pediatric patients.

References:

1. GLIZID-M. Gliclazide 80mg and Metformin 500mg. PRODUCT MONOGRAPH. Last Revised: 09 September 2014. Accessed on: 22nd July 2026. Click Here

2. Gliclazide 80 mg with Metformin 500 mg: Complete Guide for Type 2 Diabetes. Accessed on: 22nd July 2026. Click Here