Jitocefi OF 200/200 Tablet (10 Tab)

Jitocefi OF 200/200 Tablet Overview:

Jitocefi OF 200/200 Tablet is an oral broad-spectrum antibiotic used to treat typhoid fever and urinary tract infections (UTIs) in adults.

It combines two active antibacterial agents—Cefixime and Ofloxacin. This dual-action medication works by effectively stopping the growth, multiplication, and spread of harmful microorganisms in the body.

This way, Jitocefi OF 200/200 Tablet targets and treats various bacterial infections.

Composition:

Each film coated tablet contains- Cefixime as Trihydrate eq. to Anhydrous Cefixime: 200 mg and Ofloxacin: 200 mg.

Colour: Tartrazine & Titanium Dioxide

Uses & Benefits of Jitocefi OF 200/200 Tablet:

The therapeutic uses and benefits of Jitocefi OF 200/200 Tablet include:

• Typhoid Fever: Effective in managing infections caused by Salmonella typhi.
• Urinary Tract Infections (UTIs): Cures bacterial infections affecting the bladder, kidneys, and other parts of the urinary system.

How Does Jitocefi OF 200/200 Tablet Work:

The active ingredients in Jitocefi OF 200/200 Tablet—Cefixime and Ofloxacin—work synergistically via a bactericidal mechanism to fight and eliminate a wide range of both Gram-positive and Gram-negative bacteria.

Cefixime belongs to the class of third-generation cephalosporins and works by binding to penicillin-binding proteins (PBPs) on the bacterial cell membrane, preventing bacteria from building and maintaining their protective cell wall. As a result, the cell wall becomes unstable, causing the bacterial cell to rupture and die.

Ofloxacin belongs to the fluoroquinolone (quinolone) class of antibiotics. It works by inhibiting DNA gyrase (specifically topoisomerase II and IV), a crucial bacterial enzyme required for DNA replication and repair. By halting this process, Ofloxacin prevents the bacteria from multiplying and surviving, effectively stopping the spread of the infection.

Dosage of Jitocefi OF 200/200 Tablet:

• Usage Directions

Take Jitocefi OF 200/200 Tablet strictly according to your doctor’s instructions, following the prescribed dose and timing. Jitocefi OF 200/200 Tablet should be swallowed whole with water and not chewed, cut, or crushed, preferably at the same time each day. Do not stop or alter the dose of Jitocefi OF 200/200 Tablet without consulting your doctor, as this may prevent you from achieving the desired outcome. If you aren't sure how to take Jitocefi OF 200/200, check with your healthcare provider or pharmacist for instructions.

• Missed Dose

If you accidentally skip your dose of Jitocefi OF 200/200 Tablet, be sure to take it as soon as you remember later that day. If it's almost time for your dose, skip the missed dose and proceed with your usual routine. Stop taking double doses if you have forgotten one.

To help remember your daily dose, set phone alarms, use a pill organizer box, or use medication reminder apps.

• Overdose

If you take more than your prescribed dose of Jitocefi OF 200/200 Tablet by mistake, seek immediate medical attention or reach out to a poison control center right away.

Symptoms of an overdose may include severe dizziness, altered consciousness, confusion, feeling sick, seizures or fits.

Contraindications of Jitocefi OF 200/200 Tablet:

Do not take Jitocefi OF 200/200 Tablet if you have a known hypersensitivity or allergy to Cefixime, Ofloxacin, other cephalosporins, other fluoroquinolones, or any other ingredient in the medicine.

It must be avoided by patients with a history of tendonitis, tendon rupture, or musculoskeletal complications associated with prior fluoroquinolone use, as well as those with a history of epilepsy, central nervous system (CNS) disorders, or a lowered seizure threshold.

Additionally, the medication is contraindicated in individuals with latent or actual defects in glucose-6-phosphate dehydrogenase (G6PD) activity and is generally not recommended for children and growing adolescents.

Precautions & Warnings of Jitocefi OF 200/200 Tablet:

Before starting Jitocefi OF 200/200 Tablet, consult your healthcare provider and discuss your complete medical history, especially if you have pre-existing kidney or liver conditions, as dose adjustments may be required under strict medical supervision.

Due to the presence of ofloxacin, patients with a history of myasthenia gravis should exercise caution, and individuals taking antidiabetic medications must monitor their blood sugar closely, as hypoglycemic reactions can occur.

Notify your doctor if you experience pain, swelling, inflammation, or numbness, tingling, or weakness in your limbs.

Furthermore, be aware that severe allergic reactions or rare serious central nervous system disturbances, such as delirium and antibiotic-associated diarrhea, can occur during the treatment.

Side Effects of Jitocefi OF 200/200 Tablet:

Like all medicines, Jitocefi OF 200/200 Tablet can cause side effects, although not everyone will experience them. Common side effects include nausea, vomiting, diarrhea, stomach or abdominal pain, indigestion, gas, headache, insomnia, dry mouth, pruritus, fever, rash, irritated eyes, and loss of appetite.

However, seek immediate medical attention if you experience any rare or serious side effects, such as severe watery or bloody diarrhea (pseudomembranous colitis), severe allergic reactions (swelling of the face, lips, tongue, or throat, and difficulty breathing), irregular heartbeats, hypertension, hypotension, hypoglycemia, diaphoresis, urticaria, vasculitis, jaundice, severe tendon pain, genital pruritus, and vaginitis.

Label Caution: This drug may cause low blood sugar and mental health related side effects.

Safety Related Concerns of Jitocefi OF 200/200 Tablet:

• Pregnancy

Jitocefi OF 200/200 Tablet is strictly contraindicated throughout pregnancy, as its safety during pregnancy has not been established. It is essential to inform your healthcare provider if you are pregnant, planning to become pregnant, or if you suspect you might be pregnant.

• Breastfeeding

It is best to avoid taking Jitocefi OF 200/200 Tablet while breastfeeding, since one of the components of this medicine passes into breast milk and poses potential risks of toxicity or adverse side effects. Consult your healthcare provider before taking Jitocefi OF 200/200 Tablet while nursing.

• Alcohol

Avoid consuming alcohol while taking Jitocefi OF 200/200 Tablet. Alcohol can worsen side effects like dizziness, drowsiness, and stomach discomfort.

• Food Interactions

Jitocefi OF 200/200 Tablet may be taken with or without food as advised by your physician. It is always best to discuss any dietary restrictions, food sensitivities, or existing gastrointestinal conditions with your healthcare provider to ensure optimal safety and efficacy.

• Drug Interactions

Jitocefi OF 200/200 Tablet can interact with various medications, either by compromising their effectiveness or increasing the risk of toxicity. It is known to interact with antacids containing magnesium, aluminum, or calcium, as well as sucralfate, iron, and zinc supplements. It is essential to maintain a gap of at least 2 hours between consuming these mineral supplements or antacids and taking this medicine.

Additionally, caution and careful monitoring are required when co-administering blood thinners (like warfarin and other Vitamin K antagonists), anti-diabetic medications (such as glibenclamide), pain relievers (NSAIDs and corticosteroids), anti-seizure drugs (carbamazepine), theophylline, and drugs that prolong the QT interval.

Other medications like probenecid, cimetidine, furosemide, and methotrexate may also interact, so you should always provide your doctor with a complete list of all prescription medications, over-the-counter products, and supplements before starting treatment.

• Using Machinery & Driving

Jitocefi OF 200/200 Tablet may cause dizziness, sleepiness, blurred vision, confusion, or reduced alertness. Patients should avoid driving or operating machinery until they are sure the medication does not affect their alertness.

Storage of Jitocefi OF 200/200 Tablet:

Store protected from light and moisture, at a temperature not exceeding 30°C. Keep out of reach of children.

Do not use this medication past the expiry date printed on the pack. Ensure expired or leftover medicines are disposed of safely and responsibly rather than thrown into household waste.

Helpful Tips:

• Maintain proper hydration by drinking plenty of water and clear fluids, especially if experiencing diarrhea.
• Consume a healthy, balanced diet with smaller, frequent meals to minimize gastrointestinal discomfort.
• Take the medication at evenly spaced intervals to maintain a steady concentration in your bloodstream, and ensure you get adequate physical rest to support a quicker recovery.
• Continue taking your medication as prescribed, and do not discontinue it abruptly without your doctor's advice.
• Never share your medicine with others, even if they have similar symptoms. As a prescription medication, it has been specifically tailored to your individual health needs.

Frequently Asked Questions (FAQs):

Q: What is Jitocefi OF 200/200 Tablet prescribed for?

A: Jitocefi OF 200/200 Tablet is a fixed-dose combination antibiotic used for the treatment of typhoid fever and urinary tract infections (UTIs) in adults.

Q: Can I stop taking Jitocefi OF 200/200 Tablet when I start feeling better?

A: No, you must complete the full course of Jitocefi OF 200/200 Tablet, as prescribed by your doctor. Stopping early can lead to a relapse of the infection and contribute to antibiotic resistance.

Q: What are the common side effects of Jitocefi OF 200/200 Tablet?

A: Common side effects include nausea, vomiting, indigestion, diarrhea, and mild stomach discomfort. These side effects are typically mild and tend to fade as your body gets used to the medication. However, if the symptoms persist or worsen, be sure to contact your doctor.

Q: Can I take antacids or mineral supplements at the same time as this medicine?

A: You should avoid taking antacids (containing magnesium, aluminum, or calcium) or iron and zinc supplements simultaneously with Jitocefi OF 200/200 Tablet. Maintain a gap of at least 2 hours between taking these supplements and your medication, as they can interfere with how well your body absorbs the antibiotic.

Q: Can Jitocefi OF 200/200 Tablet affect my blood sugar levels?

A: Yes, this medication may cause fluctuations in blood sugar levels. If you have diabetes, you should monitor your blood glucose closely while taking this antibiotic and consult your doctor if you notice unusual readings.

Q: What should I do if I experience joint or tendon pain while taking this medicine?

A: Ofloxacin in this tablet can occasionally cause tendon inflammation or pain. If you feel any sudden pain, swelling, or weakness in your joints or tendons (especially the Achilles tendon), stop taking the medicine, rest the area, and contact your doctor immediately.

Q: Is Jitocefi OF 200/200 Tablet safe to use during pregnancy or breastfeeding?

A: This medication is generally not recommended during pregnancy or breastfeeding unless explicitly prescribed and deemed necessary by your physician, as its active ingredients can pose risks to the developing baby.

Q: Can children take Jitocefi OF 200/200 Tablet?

A: No, this medication is strictly contraindicated for children and growing adolescents. The fluoroquinolone component can negatively impact normal bone and joint development in pediatric populations.

References:

1. Jitocefi OF 200/200 Tablet. Cefixime & Ofloxacin Tablets. Accessed on: 10th September 2026. Click Here

2. MAGNICEF O Tablets (Cefixime + Ofloxacin). Accessed on: 10th September 2026. Click Here

3. TOPCEF-O 200. Cefixime & Ofloxacin Tablets. Last Revised: Aug 2019. Accessed on: 10th September 2026. Click Here

4. Cefzlan O. Cefixime & Ofloxacin Tablets. Accessed on: 10th September 2026. Click Here