Jitoace PA 100/325 Tablet (10 Tab)

Jitoace PA 100/325 Tablet Overview:

Jitoace PA 100/325 Tablet is a combination medication used to provide relief from pain and inflammation associated with various medical conditions.

It contains Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), and Paracetamol, which acts as both a pain reliever and fever reducer. Together, these ingredients help manage acute pain associated with conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and lower back pain. It is also helpful in managing musculoskeletal and soft tissue inflammation, including conditions such as sprains, strains, periarthritis, bursitis, and tenosynovitis. Additionally, it provides relief from pain associated with fractures, dislocations, headaches, dental issues, menstrual cramps, and minor surgical procedures.

Composition:

Each uncoated tablet contains- Aceclofenac: 100 mg and Paracetamol: 325 mg.

Colours: Sunset Yellow FCF.

Uses & Benefits of Jitoace PA 100/325 Tablet:

Zerodol-P Tablet is prescribed for a broad range of pain-related and inflammatory conditions. The key therapeutic benefits include:

• Musculoskeletal Pain: Provides effective relief for mild to moderate pain, including back pain, neck pain, muscle strains, and sports-related sprains.
• Arthritic Conditions: Reduces chronic pain and inflammation associated with Rheumatoid Arthritis, Osteoarthritis, and Ankylosing Spondylitis.
• Post-operative Recovery: Indicated for the management of acute inflammation and localized pain following dental procedures or minor surgical interventions.
• Pyrexia (Fever): Aids in reducing high body temperature and managing body aches typically associated with high temperatures.

How Does Jitoace PA 100/325 Tablet Work:

Jitoace PA 100/325 Tablet works through a combined mechanism of action with its two active ingredients.

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID), which works by blocking the action of chemical messengers (enzymes) called Cyclo-oxygenase (COX). These enzymes are responsible for producing prostaglandins at the site of injury or irritation, which cause pain, swelling, and heat.

On the other hand, Paracetamol is an analgesic and antipyretic agent that works by inhibiting the synthesis of prostaglandins in the central nervous system, thereby blocking the generation of pain impulses.

Hence, reducing prostaglandin production, Jitoace PA 100/325 effectively lowers pain and inflammation.

Dosage of Jitoace PA 100/325 Tablet:

• Usage Direction

Take Jitoace PA 100/325 Tablet strictly according to your doctor’s instructions, following the prescribed dose and timing. Jitoace PA 100/325 Tablet should be swallowed whole with a glass of water without crushing, chewing, or breaking it, preferably at the same time each day. Do not stop or alter the dose of Jitoace PA 100/325 Tablet without consulting your doctor, as this may prevent you from achieving the desired outcome. If you are unsure about the administration procedures of Jitoace PA 100/325, consult with your doctor or pharmacist.

• Missed Dose

If you miss a dose of Jitoace PA 100/325 Tablet, take it as soon as you remember on the same day. But, if it is almost time for your next scheduled dose, skip the one you missed and continue following your regular dosing schedule. Do not attempt to take two doses if you have forgotten one. If you often forget to take your medication, consult with your doctor to re-evaluate your dosing schedule. Frequently missing doses could lead to undesired outcomes.

You can set reminders on your smartphone, keep drug organizer boxes, or use other audio-visual technologies to prevent missing a dose.

• Overdose

If an overdose of Jitoace PA 100/325 Tablet is suspected, seek emergency medical attention immediately. Possible symptoms may consist of nausea, vomiting, stomach pain, dizziness, pancreatitis, or even more severe complications such as liver damage or kidney failure. The risk of overdose occurs when you take more than the prescribed dose; in that case, professional intervention is required.

Contraindications of Jitoace PA 100/325 Tablet:

Do not use Jitoace PA 100/325 Tablet if you are hypersensitive or allergic to Aceclofenac, Paracetamol, or any of the components of this medicine. If you previously had any allergic reactions to ibuprofen, diclofenac, or other NSAIDs (e.g., asthma, rhinitis, angioedema, or urticaria). Avoid this medicine if you have a current or past history of stomach ulcers, repeated gastric bleeding, or bleeding disorders. It should not be used in people with severe heart disease, serious liver damage, or kidney problems.

Label Warning: The product is not for veterinary use.

Precautions & Warnings of Jitoace PA 100/325 Tablet:

The use of Jitoace PA 100/325 Tablet requires careful medical supervision, particularly during long-term therapy. Because prolonged administration or high dosages can be toxic to the liver and kidneys, periodic monitoring of liver and kidney function tests is essential. Patients with a history of heart disease, asthma, diabetes, or pre-existing renal and hepatic impairment must inform their physician before taking the medicine.

Caution must be taken for elderly patients, who are more susceptible to severe adverse effects, including gastrointestinal perforation, bleeding, and the development of stomach ulcers.

Furthermore, patients with a history of gastrointestinal disorders, connective tissue diseases (such as Systemic Lupus Erythematosus), or coagulation (blood-clotting) abnormalities must be monitored closely.

Patients with cardiovascular risk factors or a history of stroke require constant medical supervision to reduce the risk of thrombotic events. Discontinue the medicine immediately at the first sign of a hypersensitivity reaction, such as a skin rash or angioedema characterized by swelling of the face, lips, or throat.

Label Warning: “Taking more than daily dose of Paracetamol may cause serious liver damage or allergic reactions (e.g. swelling of the face, mouth and throat, difficulty in breathing, itching or rash)”.

Side Effects of Jitoace PA 100/325 Tablet:

Jitoace PA 100/325 Tablet can lead to various side effects, most of which are mild as your body adapts to the medication. Common side effects include dizziness, nausea, diarrhoea, and elevated liver enzymes in the blood. Some people may notice a skin rash or itching.

Serious side effects are rare but requires immediate medical help if occurs. These include breathing difficulty, heart failure, black or bloody stools, swelling of the face or throat, and bleeding from stomach or bowel.

Safety Related Concerns of Jitoace PA 100/325 Tablet:

• Pregnancy

Jitoace PA 100/325 Tablet is not recommended during pregnancy unless unless specifically prescribed by your doctor. If you are pregnant or planning to become pregnant, talk to your doctor before taking this medication to weigh the benefits against potential risks to the developing baby.

• Breastfeeding

It is better to avoid the use of the Jitoace PA 100/325 Tablet while breastfeeding, since it is unknown whether the active ingredients of this medicine could pass into the breast milk and affect the breastfed child. Therefore, consulting with your doctor before taking Jitoace PA 100/325 is crucial.

• Alcohol

Avoid drinking alcohol while taking Jitoace PA 100/325 Tablet, as it significantly increases the risk of liver damage and stomach bleeding. Please consult with your doctor.

• Food Interactions

The interaction of certain foods with the Jitoace PA 100/325 Tablet is not known. Avoid taking it on an empty stomach to prevent acidity. Hence, it is preferred to be taken with meals or after eating to lower the risk of stomach irritation. It is also vital to follow a healthy diet by avoiding spicy, deep-fried, and acidic foods to prevent additional gastrointestinal irritation and facilitate better absorption.

• Drug Interactions

Jitoace PA 100/325 Tablet may interact with other drugs, potentially compromising their effectiveness. It could lower the efficacy of antihypertensive medications or diuretics, which might cause kidney issues. Furthermore, it can elevate lithium or digoxin levels by decreasing their elimination rate. Concomitant use of Jitoace PA 100/325 and other NSAIDs and corticosteroids may lead to increased risk of gastrointestinal ulceration or hemorrhage. Also, seek caution when co-administered with anticoagulants (such as Heparin and Warfarin) due to an increased risk of bleeding, and with Quinolone antibiotics, which may elevate the risk of convulsions.

Additionally, caution is advised when co-administered with blood thinners (heparin and warfarin) due to an increased risk of bleeding, and with quinolone antibiotics. Paracetamol interacts with medications that are metabolized by the liver enzymes. It may interact with rifampicin, isoniazid, chloramphenicol, and various antiepileptic drugs and antiviral medicines. Furthermore, the co-administration of Cholestyramine should be monitored, as it can reduce the gastrointestinal absorption of Paracetamol, thereby delaying its onset of action.

• Using Machinery & Driving

Jitoace PA 100/325 Tablet may cause side effects like dizziness, vertigo, drowsiness, fatigue, or visual disturbances in some people. Patients should use caution and avoid driving or operating machinery until they are sure the medication does not affect their alertness.

Storage of Jitoace PA 100/325 Tablet:

Store protected from moisture, at a temperature not exceeding 30°C. Keep out of reach of children. Avoid using it after the expiry date, printed on the packaging. Dispose of expired or unused medication properly; do not throw it away casually.

Additional Information:

• Do not share your medicine with someone else having the same symptoms as you.
• If you are scheduled for any surgical or dental procedure, inform the treating physician that you are taking an NSAID, as it may need to be temporarily discontinued to reduce perioperative bleeding risk.
• Do not suddenly stop your medication unless your doctor specifically tells you to.
• Long-term use of this combination without medical supervision is discouraged, as it may lead to serious gastrointestinal, renal, or cardiovascular complications.
• Regular follow-up with your healthcare provider is essential during prolonged treatment.
• For injuries, follow the R.I.C.E. method (Rest, Ice, Compression, Elevation) to support anti-inflammatory action.
• Seek medical advice if pain persists or recurs to avoid chronic self-medication.

Frequently Asked Questions (FAQs)

Q. What are the uses of Jitoace PA 100/325 Tablet?

A. Jitoace PA 100/325 Tablet is mainly used to reduce pain and inflammation in conditions like arthritis (osteoarthritis, rheumatoid arthritis), ankylosing spondylitis, muscle pain, backaches, and post-operative or dental pain.

Q. How long does it take for the medicine to work?

A. While the absorption and metabolism rate of the medicine may differ in different individuals. But, most patients feel relief within 30 to 60 minutes of consumption. The effects typically last for about 6 to 8 hours.

Q. Can I take Jitoace PA 100/325 for a headache or fever?

A. Yes, because Jitoace PA 100/325 contains Paracetamol, which is effective for managing headaches, migraines, and reducing fever associated with body aches. But it should not be used as a routine pill without consulting a doctor.

Q. Is Jitoace PA 100/325 Tablet a painkiller?

A. Yes, Jitoace PA 100/325 Tablet is considered a painkiller. It combines Paracetamol, which helps relieve pain and reduce fever, with Aceclofenac, which decreases inflammation. Together, they effectively manage pain and inflammation associated with various conditions such as arthritis, muscle pain, back pain, dental pain, and discomfort following injury or minor surgical procedures.

Q. Is it safe to take Jitoace PA 100/325 Tablet on an empty stomach?

A. No, avoid taking the medication on an empty stomach. Generally, it is recommended to be taken with food or liquid to minimize the risk of stomach upset, acidity, or gastric ulcers.

Reference:

1. ACYCLOSURE P. Aceclofenac and Paracetamol Tablets. Last Revised: December 2021. Accessed on: 21st March 2026. Click Here

2. Patient Information Leaflet. Aceclofenac 100mg & Paracetamol 500mg Tablets (Dolowin-Plus). Last Revised: July 2019. Accessed on: 21st March 2026. Click Here

3. MAHADOL Tablet. Aceclofenac / Paracetamol 100 / 325 mg Tablet. Package leaflet: Information for the user. Accessed on: 21st March 2026. Click Here

4. ACECLOFENAC AND PARACETAMOL TABLETS. Accessed on: 21st March 2026. Click Here