Esopep Capsule (10 Cap)

Esopep Capsule Overview:

Esopep Capsule is a combination medicine, used to treat symptoms of GERD (gastroesophageal reflux disease) and related digestive issues, when Esomeprazole alone is not effective enough to manage.

Gastroesophageal reflux disease occurs when stomach acid flows back into the food pipe, leading to heartburn and possible esophageal injury. Esopep Capsule is composed of two main ingredients: Esomeprazole and Domperidone. Esomeprazole reduces stomach acid production, while Domperidone helps improve stomach movement and prevents nausea. Together, they effectively relieve post-prandial symptoms of fullness, bloating, nausea, indigestion, heartburn, stomach pain, peptic ulcers, and other symptoms caused by hyper-acidity.

Composition of Esopep Capsule:

Each hard gelatin Capsule contains Esomeprazole Magnesium Trihydrate equivalent to Esomeprazole (as enteric coated pellets): 40 mg, Domperidone (as sustained release pellets): 30 mg and Excipients q.s.

Brilliant Blue and Tartrazine colours used in empty capsule shell.

Uses and Benefits of Esopep Capsule:

Esopep Capsule is prescribed for the following conditions:

• Provides long-lasting relief from Gastroesophageal Reflux Disease (GERD/Acid Reflux), where stomach acid backs up into the esophagus, leading to heartburn and irritation.

• Relieves bloating, discomfort, and acid-related indigestion by reducing stomach acid production.

• Reduces heartburn caused by acid reflux.

• Eases gastritis caused by excess stomach acid or Helicobacter pylori bacterial infection.

• Heals Zollinger-Ellison syndrome and peptic ulcer by lowering stomach acid levels.

• Relieves symptoms of acidity and hyperacidity, such as stomach pain, irritation, and discomfort.

How Esopep Capsule works:

Esopep Capsule contains two active ingredients: Esomeprazole and Domperidone, which work together to treat conditions caused by too much stomach acid and improve digestion.

Esomeprazole is a selective Proton Pump Inhibitor (PPI) that works by blocking the proton pump in the stomach lining, which is responsible for producing gastric acid. By inhibiting this enzyme, it effectively reduces stomach acid production, lowering acidity and helping to treat conditions like GERD, acid reflux, and peptic ulcers.

Domperidone, on the other hand, is a gastro-prokinetic and anti-nausea drug. It works by blocking dopamine receptors in the upper part of the digestive system, helping food move through the stomach and preventing nausea and vomiting.

Dosage of Esopep Capsule:

• Usage Direction

Take Esopep Capsule strictly according to the prescribed dose and time, as directed by your doctor. It is important to swallow Esopep Capsule whole without chewing, crushing or breaking it, and ideally at the same time each day. Do not stop or change the dosage of Esopep without consulting your doctor, as this may prevent you from achieving the desired results. If you are unsure about the method of administration of Esopep, consult your doctor or pharmacist.

• Missed Dose

In case you miss a dose of Esopep Capsule, take it as soon as it is remember. If it is nearly time for your next dose of Esopep, skip the missed dose and continue with your regular dosing plan. Avoid taking a double dose of Esopep to make up for a missed one.

• Overdose

If you accidentally take Esopep Capsule more than your prescribed dose, seek immediate medical advice, as this may cause nausea, vomiting, dizziness, abdominal pain, diarrhea, headache, depression, altered consciousness or hyper motility.

Contraindications of Esopep Capsule:

Do not take Esopep Capsule if you are allergic or hypersensitive to esomeprazole, other proton pump inhibitors, domperidone, other dopamine antagonists or other ingredients of this medication. Esopep Capsule should also be avoided if you have moderate to severe liver or kidney disease, a tumour of the pituitary gland (prolactinoma), stomach or intestinal bleeding, intestinal blockage, or perforation. It is also unsafe for people with heart rhythm problems, heart failure, or low potassium or magnesium levels, and also if you are taking any medicine to treat of HIV-infection.

Precautions & Warnings of Esopep Capsule:

Before starting Esopep Capsule, inform your doctor if you have severe liver or kidney disease, gastric ulcers or gastrointestinal surgery, low magnesium levels, bone fractures, atrophic gastritis, acute interstitial nephritis, and Clostridium difficile–associated diarrhea. Also, let your doctor know if you are taking this medicine for a long time, which may lead to Vitamin B12 deficiency.

Side Effects of Esopep Capsule:

Esopep Capsule may cause some side effects, most of which do not require medical attention and typically go away as your body adjusts to the medication. However, if these side effects continue or worsen, consult your doctor as soon as possible. These may include: headache, diarrhea or constipation, nausea or vomiting, abdominal pain or discomfort, gas, dry mouth, and dizziness. To help manage these, drink plenty of water, avoid foods that may cause gas, eat fibre-rich foods, and rest if you experience lightheadedness. Additionally, some uncommon side effects have also been reported, such as swelling of the hands, feet, ankles, lips or throat, irregular eye movements, twisted neck, trembling and muscle stiffness, unusual heartbeat and fit (seizure).

Safety Related Concerns of Esopep Capsule:

• Pregnancy

If you are pregnant or planning to become pregnant, consult your doctor to determine whether Esopep is safe. This medicine may affect the development of your baby during pregnancy.

• Breastfeeding

Breastfeeding mothers are advised to avoid Esopep Capsule, as it may pass through breast milk and can cause side effects in breastfed babies. Therefore, it is important to consult your doctor before taking Esopep Capsule while breastfeeding.

• Alcohol

Although the direct interaction between Esopep Capsule and alcohol has not been determined, alcohol can increase stomach acid, worsen acid reflux, and increase the risk of side effects such as dizziness and irregular heartbeat. Therefore, it is generally advisable to avoid alcohol while undergoing treatment with this Capsule. If you notice any unusual symptoms after drinking alcohol while taking Esopep Capsule, contact your doctor immediately.

• Food or Interactions with Other Medicines

Avoid spicy or junk foods, citrus foods (Like oranges, lemons, grapefruits, acidic foods (tomatoes), high-fat foods, carbonated drinks (soda) while taking Esopep Capsule.

Consult your doctor if you take any herbal products or supplements while taking Pan D Capsule. As always, it is a good idea to consult your doctor or healthcare provider about your specific dietary needs while on Esopep Capsule. Consult your doctor if you are taking any herbal products, supplements or other medicines while taking Esopep Capsule. As always, please consult your doctor or healthcare provider about your specific dietary needs while on Esopep Capsule.

• Driving & Operating Machinery

If you experience side effects such as dizziness or tiredness that affect alertness, you should avoid driving or operating machinery while taking Esopep Capsule.

Storage of Esopep Capsule:

Store in a cool & dry place. Protect from direct sunlight.

Keep Esopep Capsule out of reach of children.

Note: Eating smaller, more frequent meals, maintaining a healthy and balanced diet, along with regular exercise, can help improve your condition.

Frequently Asked Questions (FAQs) about Esopep Capsule:

1. What is Esopep Capsule used for?

Esopep Capsule is used to manage conditions such as gastroesophageal reflux disease (GERD), acid reflux, peptic ulcers, and indigestion. It works by lowering stomach acid production, which helps alleviate symptoms like heartburn and discomfort. Additionally, it enhances gastric motility, promoting better digestion. This combination helps in providing relief from acid-related conditions and improving overall digestive health.

2. What is the ideal time to take Esopep Capsule, before food or after food?

Take Esopep Capsule with or without food, as recommended by your doctor based on your condition. However, it is usually recommended to be taken before food, preferably 30 minutes to 1 hour before a meal. This helps the medication work well by lowering stomach acid before food arrives in the stomach. Always follow your doctor's instructions regarding timing for the best results.

3. Can Esopep Capsule be taken daily?

Typically, Esopep Capsule can be taken daily, preferably on an empty stomach, but the exact dosage may vary depending on your condition. It is important to follow your doctor’s advise and never take more than the recommended dose.

4. Which is better, Esopep or Pan D?

Both Esopep and Pan D are used to treat acid-related conditions such as GERD, indigestion, nausea, and bloating, but they differ in composition. Esopep contains Esomeprazole and Domperidone, while Pan D contains Pantoprazole and Domperidone. Your doctor will choose the most suitable medicine based on the severity of your symptoms, your overall health, and how well you tolerate the medication.

 5. Are there any specific dietary restrictions while taking Esopep Capsule?

Yes, while using Esopep Capsule, it is recommended to avoid spicy, oily, or fatty foods, as well as caffeine-containing beverages like coffee and tea, carbonated drinks, and acidic foods such as citrus fruits and vegetables. For better dietary guideline, consult a registered dietitian or physician who can provide personalized guidance based on your specific condition.

6. Is Esopep Capsule safe for gastritis treatment?

Esopep Capsule may be used to treat gastritis, depending on the underlying cause and severity of the condition. It contains Esomeprazole, which reduces stomach acid production, and Domperidone, which aids in gastric motility and helps alleviate nausea and bloating. If gastritis is caused by excessive stomach acid or delayed gastric emptying, Esopep Capsule can help by addressing both issues.

Reference:

1. Omez DSR +. Enteric Coated Esomeprazole 40mg Domperidone Sustained Release 30mg Capsules. Last Revised: March 2023. Accessed on 01.07.2025. Click Here

2. NEXPRO RD. Esomeprazole Magnesium and Domperidone Sustained Release Capsules. Last Revised: February 2022. Accessed on 01.07.2025. Click Here

3. PATIENT INFORMATION LEAFLET. Esomeprazole Enteric-Coated & Domperidone Sustained-Release Capsules (ESOFAG-D). Last Revised: May 2024. Accessed on 01.07.2025.Click Here

4. Package leaflet: Information for the user ZOSA DSR® 40/30 mg Capsule Esomeprazole gastro-resistant tablet 40 mg IP. Accessed on 01.07.2025. Click Here