Apriglim MF 2 mg Tablet (15 Tab)

Apriglim MF 2 Tablet Overview:

Apriglim MF 2 Tablet is an oral anti diabetic medicine, used to treat Type 2 diabetes mellitus.

This dual action formula, prescribed when lifestyle changes, such as diet, exercise, and previous treatment with a single oral anti diabetic medication, fail to control blood sugar levels effectively.

Type 2 diabetes can lead to serious complications, including cardiovascular disease such as heart attack and stroke, as well as kidney damage, nerve damage, vision problems, slow wound healing, etc.

Apriglim MF 2 Tablet also plays an important role by enhancing the body's response to insulin or increasing the body's production of insulin, thereby reducing the risk of these potentially debilitating symptoms.

It is important to note that Apriglim MF 2 Tablet is not for treating Type 1 diabetes or diabetic ketoacidosis.

Composition of Apriglim MF 2 Tablet:

Each uncoated bilayered tablet contains: Metformin Hydrochloride (As sustained release form) 1000 mg, Glimepiride 2 mg and Excipients q.s.

Colour: Lake Yellow Oxide of Iron & Lake Indigo carmine.(In the Glimepiride layer)

Uses and Benefits of Apriglim MF 2 Tablet:

Apriglim MF 2 Tablet is used for the treatment of Type 2 diabetes mellitus or non-insulin-dependent diabetes mellitus (NIDDM).

How Apriglim MF 2 Tablet Works:

Apriglim MF 2 Tablet is a combination of two anti diabetic medications, glimepiride and metformin.

Glimepiride, a sulfonylurea, lowers blood sugar by increasing the release of insulin from the pancreas. Meanwhile, metformin, a biguanide, works by decreasing the glucose production in the liver, slowing the absorption of glucose in the intestines, and enhancing the body's response to insulin.

Together, they help improve glycemic control in type 2 diabetes mellitus.

Dosage of Apriglim MF 2 Tablet:

• Usage Direction

Take Apriglim MF 2 Tablet exactly as prescribed by your doctor, and follow the recommended dosage and schedule. Apriglim MF 2 should be swallowed as a whole without crushing, chewing, or breaking it, and ideally at the same time each day. Do not stop or alter the dose of Apriglim MF 2 Tablet without consulting your doctor, as this may prevent you from achieving the desired outcome. Ask your doctor or pharmacist to explain any administration procedure you do not understand.

• Missed Dose

If you miss a dose of Apriglim MF 2 Tablet, take it as soon as it is remembered. If it is time for your next dose of Apriglim MF 2 Tablet, skip the missed dose and resume your regular schedule. Do not double the dose to make up for the missed dose.

• Over Dose

If you accidentally take Apriglim MF 2 Tablet more than your prescribed dose, it may lead to severe hypoglycemia or lactic acidosis. To manage hypoglycemia on an emergency basis, take fast-acting carbohydrates like sugar, fruit juice, honey, etc and seek medical advice immediately.

Contraindications of Apriglim MF 2 Tablet:

Do not take Apriglim MF 2 Tablet, if you are hypersensitive or allergic to glimepiride, metformin, or any of the components.  Avoid taking Apriglim MF 2 Tablet if you have Type 1 or insulin-dependent diabetes mellitus, diabetic ketoacidosis, diabetic coma, decompensated heart failure, respiratory failure, or recent myocardial infarction, severe kidney or liver disease.

Precautions & Warnings of Apriglim MF 2 Tablet:

Apriglim MF 2 requires careful use due to risks of hypoglycemia and metformin-related lactic acidosis. Monitor kidney function regularly, especially in elderly patients or those with heart, liver, or dehydration-related conditions. Watch for low-sugar symptoms like sweating, dizziness, or confusion, and keep fast-acting glucose handy. Seek urgent care for unusual tiredness, muscle pain, or breathing difficulty. Avoid alcohol and stop the medicine temporarily during acute illness, surgery, or contrast studies. Use cautiously in G6PD deficiency due to hemolytic anemia risk. Not recommended in pregnancy, breastfeeding, severe renal impairment, or irregular meal patterns.

Side Effects of Apriglim MF 2 Tablet:

Apriglim MF 2 Tablet may also cause some side effects, most of which do not require medical attention and typically go away as your body adapts to the medication. These may include nausea, diarrhea, abdominal pain, constipation, vomiting and a metallic taste in the mouth. However, if these side effects persist, consult your doctor as soon as possible. Some of the side effects may also be serious and may need medical attention, such as hypoglycaemia, lactic acidosis, diarrhoea, bloating, abdominal pain, fatigue or pale skin and allergic reaction. Long-term use of this medicine can decrease vitamin B12 absorption, and can cause vitamin B12 deficiency.

Safety Related Concerns of Apriglim MF 2 Tablet:

• Pregnancy

If pregnancy is discovered, or you are planning to become pregnant, it is important to consult with your doctor to determine whether it is safe for you to continue Apriglim MF 2 Tablet.

Gestational diabetes, which occurs during pregnancy, carries an increased risk of birth defects. Therefore, your doctor may recommend switching to insulin therapy to control blood sugar levels better. It is essential to monitor blood glucose levels closely throughout pregnancy to minimize the risk of fetal malformations.

• Breastfeeding

Breastfeeding mothers are advised to avoid Apriglim MF 2 Tablet as it may pass through breast milk and can cause side effects in breastfed babies. Therefore, it is important to consult your doctor before taking Apriglim MF 2 while breastfeeding.

• Alcohol

It is recommended to avoid drinking alcohol while taking Apriglim MF 2 Tablet, as it can increase the risk of low blood sugar (hypoglycemia) and may also cause lactic acidosis.

• Food Interactions

Avoid excessive sugary foods and refined carbohydrates that cause rapid glucose spikes difficult to manage even with medication. Maintain balanced diets with whole grains, lean protein, healthy fats, and plenty of vegetables and fruits. Ask your doctor before drinking grapefruit juice, as it may interact with some medicines. Stay well-hydrated and avoid dehydration caused by heat, illness, or not drinking enough fluids, because it can increase the risk of lactic acidosis while taking Apriglim MF 2.

• Drug Interactions

Many medicines can interact with Apriglim MF 2 and may increase side effects or reduce its effect. Other diabetes drugs, insulin, some antibiotics, antifungals, salicylates, and warfarin can raise the risk of low blood sugar. Steroids, diuretics, thyroid medicines, birth control pills, phenytoin, and stimulants may increase blood sugar. Beta-blockers can hide warning signs of hypoglycemia, while NSAIDs may enhance glimepiride’s effect. Cimetidine and some HIV drugs can raise metformin levels. Metformin must be stopped before contrast imaging until kidney function is confirmed normal. Always tell your doctors about all medicines, supplements, and herbal products you use.

• Using Machinery & Driving

Apriglim MF 2 can affect your ability to drive or operate machinery mainly through the risk of low blood sugar, which causes symptoms like blurred vision, confusion, or drowsiness that mimic intoxication. If you are new to the medication or adjusting doses, avoid these activities until you know how it impacts you—test sugar before long trips and keep snacks handy. Consult your doctor for personalized tips.

Storage of Apriglim MF 2 Tablet:

Apriglim MF 2 Tablet must be stored between 10°C to 25°C at dry and dark place. Dispose of expired or unneeded medications properly through local regulations or pharmacy take-back programs rather than flushing or household trash disposal. Check expiration dates regularly and never use expired medication, as potency may decrease or safety may be compromised.

Keep Apriglim MF 2 Tablet out of reach of children.

Additional Note:

• Monitor blood sugar, urine tests, cholesterol, and HbA1c regularly.

• Follow a healthy diet, exercise daily, and maintain a healthy weight.

• Carry quick sugar sources in case of low blood sugar.

• Attend all medical appointments and complete recommended lab tests.

Related Blood Glucose Monitors:

To manage diabetes at home, discover our simple, reliable home-use Blood Glucose Monitoring systems with Test Strips. Check Out

Frequently Asked Questions (FAQs):

Q1. What is Apriglim MF 2 Tablet used for?

A. Apriglim MF 2 Tablet is used for the treatment of Type II diabetes mellitus.

Apriglim MF 2 Tablet is used along with proper diet and physical exercise to improve glycemic control in patients, especially for those whose diabetes is not adequately controlled with a single oral anti diabetic medicine.

Q2. Can Apriglim MF 2 cause low blood sugar?

A. Apriglim MF 2 Tablet is usually recommended for managing Type II diabetes mellitus. However, taking more than the prescribed dose or using it alongside other anti diabetic medications can lead to dangerously low blood sugar levels, a condition known as hypoglycemia.

Q3. Is Apriglim MF 2 Tablet an insulin?

A. No, Apriglim MF 2 Tablet is not an insulin. While insulin is a hormone, Apriglim MF 2 Tablet is a combination of two oral anti diabetic drugs: Glimepiride and Metformin. It is commonly prescribed to individuals with type 2 diabetes to help regulate blood sugar levels.

Q4. What is the difference between Glycomet Tablet and Apriglim MF 2 Tablet?

A. The primary difference between Glycomet Tablet and Apriglim MF 2 Tablet lies in their composition, both of which are used to treat Type II diabetes mellitus. Apriglim MF 2 Tablet combines Glimepiride and Metformin, while Glycomet Tablet contains only Metformin. It is essential to take only the medication prescribed by your doctor according to your physical condition and avoid self-medication.

Q5. What happens if blood sugar drops too quickly?

A. When blood sugar levels drop too quickly, it can result in hypoglycemia. Symptoms may include shaking or trembling, dizziness, weakness, a rapid heart rate, sweating, and chills. In severe cases, it can cause confusion, seizures, or even coma, which can be life-threatening. To manage hypoglycemia in an emergency basis by consuming fast-acting carbohydrates such as glucose tablets, sugary products, or regular soda to restore blood sugar to normal levels.

Q6. Which food should avoid during this medication?

A. While using Apriglim MF 2 Tablet, it is advisable to avoid foods and drinks high in natural or added sugars, such as fruit juice, soda, candy, desserts, white bread, rice, chips, sugary cereals, ice cream, and sweetened milk. Additionally, alcohol should be avoided during this treatment as it can lower blood sugar levels, increasing the risk of hypoglycemia, and may also raise the likelihood of developing lactic acidosis.

Q7. Can Apriglim MF 2 Tablet cause weight gain?

A. Yes, Apriglim MF 2 Tablet may cause weight gain due to its ingredient Glimepiride, which belongs to the Sulfonylureas class of medications. Sulfonylureas work by stimulating the pancreas to produce more insulin, which helps lower blood sugar levels. However, insulin also promotes fat storage in the body. As a result, increased insulin levels can lead to the storage of more fat, potentially causing weight gain. If you're concerned about weight gain while taking Apriglim MF 2 Tablet, it is important to discuss it with your healthcare provider. They can adjust your treatment plan to help manage both your blood sugar and weight.

References:

1. METFORMIN + GLIMEPIRIDE. Contents. Glimepiride 2 mg, metformin HCl 500 mg. Accessed on 05.02.2025. Click Here

2. PATIENT INFORMATION LEAFLET. ILET B. Accessed on 05.02.2025. Click Here

3. AZULIX MF (Glimepiride and Metformin Hydrochloride Sustained Release Tablets). Last Revised - January 2016. Accessed on 05.02.2025. Click Here

4. Metformin. Last Revised - 02/15/2024. Accessed on 05.02.2025. Click Here