Advastat F Tablet (10 Tab)

Advastat F Tablet Overview:

Advastat F Tablet is a combination lipid-lowering medication used to control high levels of fats (cholesterol and triglycerides) in the blood. It is especially helpful for people who have both high cholesterol and high triglycerides, and who are at risk of cardiovascular disease. It is usually taken along with a healthy diet when one medicine alone is not enough.

This tablet contains two ingredients: Rosuvastatin and Fenofibrate. Rosuvastatin helps lower “bad” cholesterol (LDL), while Fenofibrate reduces triglycerides and increases “good” cholesterol (HDL).

High fat levels in the blood (called hyperlipidemia) can lead to fat deposits in blood vessels. Over time, this can cause plaque formation in the coronary arteries (atherosclerosis), leading to major cardiovascular complications like heart attacks or strokes.

By combining both medicines, Advastat F Tablet works in two ways to better control cholesterol and triglycerides, helping to protect your heart and reduce the future cardiovascular disease.

Composition:

Each film coated tablet contains- Rosuvastatin Calcium equivalent to Rosuvastatin: 10 mg, Fenofibrate: 160 mg, and Excipients q.s.

Colours: Lake Quinoline Yellow & Titanium Dioxide

Uses & Benefits of Advastat F Tablet:

Advastat F Tablet is used to manage high levels of cholesterol and triglycerides in the blood, including:

• Mixed Dyslipidemia-

Advastat F Tablet helps control both high cholesterol and high triglyceride levels together, improving the overall lipid balance when a single medicine is not enough.

• Hypercholesterolemia-

It lowers “bad” cholesterol (LDL) and increases “good” cholesterol (HDL), helping to maintain healthy cholesterol levels and support heart health.

• Hypertriglyceridemia-

It significantly reduces high triglyceride levels in the blood, which helps lower the risk of fat buildup in blood vessels.

• Prevention of Cardiovascular Events-

By improving cholesterol and triglyceride levels, Advastat F Tablet helps reduce the risk of serious heart problems such as heart attack, stroke, and other cardiovascular complications, especially in high-risk patients.

How Does Advastat F Tablet Works:

The two active ingredients in Advastat F Tablet work through two distinct mechanisms. Rosuvastatin belongs to a group of medicines called HMG-CoA reductase inhibitors (statins). It blocks the action of the HMG-CoA reductase enzyme in the liver, which plays a key role in producing cholesterol. By slowing down cholesterol synthesis, the tablet helps eliminate more "bad" (LDL) cholesterol from the bloodstream.

Along with this, Fenofibrate, a derivative of ‘fibric acid,’ activated the peroxisome proliferator-activated receptor-alpha (PPAR-a). This activation increases the breakdown of fats by enhancing the activity of the enzyme lipoprotein lipase, which specifically targets and eliminates excess triglycerides while boosting "good" (HDL) cholesterol levels. Together, these two processes provide a comprehensive approach to improving the overall lipid profile and reducing cardiovascular risk.

Dosage of Advastat F Tablet:

• Usage Direction

Advastat F Tablet should be taken strictly as per the doctor’s advice, following the prescribed dose and timing. Advastat F Tablet should be swallowed whole with water and do not crush, chew or break the tablet. Take Advastat F Tablet preferably at the same time each day. Do not stop or alter the dose of Advastat F without consulting your doctor, as this may prevent you from achieving the desired outcome. If you are unsure about the administration procedures of this medication, consult with your doctor or pharmacist.

• Missed Dose:

If you miss a dose of Advastat F Tablet, take it as soon as you remember on the same day. But, if it is almost time for your next scheduled dose, skip the one you missed and continue following your regular dosing schedule. Do not attempt to take two doses if you have forgotten one. If you often forget to take your medication, consult with your doctor to re-evaluate your dosing schedule. Frequently missing doses could lead to undesired outcomes.

You can set reminders on your smartphone, keep drug organizer boxes, or use other audio-visual technologies to prevent missing a dose.

• Overdose:

If you accidentally take Advastat F Tablet more than your prescribed dose, seek immediate medical advice, or contact a poison control center. Overdose may lead to serious side effects, so it should be managed through asymptomatic supportive care.

Contraindications of Advastat F Tablet:

Do not take Advastat F Tablet if you are hypersensitive or allergic to Rosuvastatin, Fenofibrate, or any of the components of this medicine. Symptoms of allergic reactions include rash, itching, hives, or swelling.

Advastat F is not to be used by patients with severe liver disease, gallbladder disease, severe kidney impairment, or unexplained persistent elevations in liver enzymes. It should also not be used in individuals with a history of statin-induced muscle disorders.

Precautions & Warnings of Advastat F Tablet:

Before starting Advastat F Tablet, inform your doctor about your complete medical history, especially if you have liver or kidney disease, hypothyroidism, diabetes, genetic muscle disorders, or a history of alcohol abuse or adverse reactions to statins or fibrates. These conditions may require dose adjustments and close monitoring.

This medicine can increase the risk of muscle-related problems such as pain, tenderness, or weakness, and in rare cases, serious muscle breakdown that may affect the kidneys. Seek immediate medical attention if you experience unexplained muscle symptoms, especially with fever, tiredness, or dark urine.

Regular monitoring of liver function, kidney function, and blood glucose levels is recommended during treatment. Elderly patients and those with kidney issues or a history of pancreatitis should use this medicine cautiously under proper medical supervision.

Label Statin Warning: Patients should notify to their healthcare professional immediately if they have following symptoms: Liver problems, unusual fatigue or weakness, loss of appetite, upper belly pain, dark colored urine, yellowing of skin or eyes, memory loss confusion and increase in blood sugar levels.

Side Effects of Advastat F Tablet:

Advastat F Tablet may cause various side effects, most of which are mild and temporary as the body adjusts to the medication. Commonly reported symptoms include headache, dizziness, nausea, stomach pain, muscle aches, and general weakness. In some cases, patients may also notice an increase in blood sugar levels.

Serious side effects that require urgent medical attention include signs of rhabdomyolysis, which is characterized by severe, unexplained muscle pain, tenderness, or weakness. Additionally, although rare, patients should be alert for symptoms of pancreatitis, elevated liver enzymes (indicated by yellowing of the eyes/skin), hematuria (blood in urine), or proteinuria. Severe allergic reactions—such as swelling of the face or throat and difficulty breathing—also require immediate emergency care.

Safety Related Concerns of Advastat F Tablet:

• Pregnancy

Advastat F Tablet must not be used during pregnancy. Cholesterol plays an important role in the normal development of the baby, and lowering its levels with medicines like rosuvastatin may harm the unborn child. In addition, there is limited safety information available for fenofibrate during pregnancy, and the combined use may increase potential risks.

Women who are pregnant or planning to become pregnant should use effective contraception while taking Advastat F Tablet and consult their doctor immediately.

• Breastfeeding

Taking Advastat F Tablet while breastfeeding is not recommended. The active ingredients, particularly Rosuvastatin, may be excreted into breast milk and could interfere with the infant's essential lipid metabolism. It is best to discontinue use during lactation and consult a healthcare professional for safer alternatives to manage cholesterol while nursing.

• Alcohol

It is highly advisable to avoid or strictly limit alcohol consumption while on this medication. Excessive alcohol intake significantly increases the risk of liver damage and can lead to a further spike in triglyceride levels, counteracting the benefits of the treatment.

• Food Interactions

Advastat F Tablet can be taken with or without food, but certain food choices might influence its effectiveness. It is suggested to avoid large quantities of grapefruit or grapefruit juice, as compounds in the fruit can interfere with the liver's ability to metabolize Rosuvastatin, potentially leading to increased side effects. For better effectiveness of this medicine, patients should maintain a balanced diet by limiting foods rich in fats or lipids, particularly those with high saturated fats, trans fats, or dietary cholesterol.

• Drug Interactions

Advastat F Tablet can interact with various medications, either by compromising their effectiveness or increasing the risk of toxicity. Rosuvastatin component is highly sensitive to certain HIV protease inhibitors, azole antifungals (e.g., itraconazole), and antibiotics (e.g., clarithromycin). These medications can cause Rosuvastatin to reach dangerously high levels in the blood, significantly raising the risk of severe muscle damage (rhabdomyolysis). If taking hormone replacement therapy (HRT) or oral contraceptives, Rosuvastatin can increase the plasma concentrations of ethinyl estradiol and norgestrel and can increase the risk of hormone-related side effects like breakthrough bleeding or nausea. Additionally, concomitant use with other fibrates (like gemfibrozil) or niacin necessitates careful monitoring and potential dose adjustments to manage muscle-related risks. Caution is required when using Fenofibrate alongside anticoagulants like Warfarin, as it can enhance the blood-thinning effect and increase the risk of bleeding. It is also important to note that taking antacids or bile acid sequestrants too close to your dose can interfere with the absorption of the medication.

• Using Machinery & Driving

There is no significant impact on the ability to drive or operate machinery while taking Advastat F. However, if you feel affected and experience dizziness, then you should avoid doing such activities.

Storage of Advastat F Tablet:

Store protected from light and moisture at a temperature not exceeding 30°C. Keep the medicine out of reach of children. Avoid using it after the expiry date, printed on the packaging. Dispose of expired or unused medication properly; do not throw it away casually.

Additional Information:

• Follow a low-fat, low-cholesterol diet and avoid saturated and trans fats.
• Stay physically active with regular exercise.
• Maintain a healthy body weight
• Eat fiber-rich foods like oats, fruits, and beans.
• Limit alcohol and quit smoking for better results.
• Do not stop the medicine without advice and never share it with others.
• Do not discontinue the medicine without consulting your doctor, even if your cholesterol levels improve, as stopping suddenly may worsen your condition.

Frequently Asked Questions (FAQs):

Q. What is Advastat F Tablet used for?

A. Primarily, Advastat F Tablet is used to reduce high cholesterol and triglyceride levels in the bloodstream, which helps prevent heart attacks and strokes when used in conjunction with a healthy diet and regular exercise. It enhances lipid control for conditions like mixed hyperlipidemia.

Q. How long does it take for Advastat F Tablet to work?

A. The effect varies by individual and lipid levels. Initial improvement may be seen within few weeks, but optimal results usually require consistent use for several weeks to months, along with a proper diet and lifestyle changes. Your doctor will likely order a blood test after a few weeks to monitor your progress.

Q. Can I take Advastat F Tablet at any time of the day?

Yes, Advastat F Tablet can be taken at any time of the day, with or without food. However, it is important to take it at the same time each day to maintain consistent levels in the body. However, your doctor may recommend the best time based on your condition and overall treatment plan.

Q. Can Advastat F Tablet cause muscle pain?

A. Yes, Advastat F Tablet can cause muscle pain, as it is one of the side effects of this medicine, although it doesn't affect everyone. If you experience persistent pain or weakness, especially with fever, contact your doctor immediately as it could indicate a rare muscle disorder.

Q. Does this medicine cause weight gain?

A. Advastat F Tablet does not typically cause weight gain. It works to control cholesterol and triglyceride levels, not body weight. However, maintaining a healthy diet and regular exercise is important for overall health and better treatment results.

Q. Will I have to take Advastat F Tablet for the lifetime?

A. It depends on your condition and risk factors. High cholesterol is often a long-term condition, so this medicine may be needed for an extended period. Your doctor will regularly assess your lipid levels and overall health to decide the duration of treatment. Do not stop taking it without medical advice, even if your levels improve.

Q. Taking Advastat F Tablet could cause Diabetes Mellitus?

A. Advastat F Tablet may slightly increase blood sugar levels in some people, especially those already at risk of diabetes. However, the overall benefit in reducing heart disease risk usually outweighs this small risk. Regular monitoring of blood glucose is recommended during treatment.

References:

1. ROSTAR F. Last Revised: Dec-20. Accessed on: 17th March 2026. Click Here

2. ROSULIP-F Tablets. Last Revised: Dec 2015. Accessed on: 17th March 2026. Click Here

3. Rosuvastatin and Fenofibrate Tablets IP 10mg/160mg (Rosutaj-F) Taj Pharma. Accessed on: 17th March 2026. Click Here